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{
"count": 43797,
"next": "https://cinder.proteo.info/api/ms_vocab/?format=api&limit=20&offset=1240&ordering=-accession",
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"results": [
{
"accession": "PR:000001128",
"name": "chemokine receptor",
"definition": "['A rhodopsin-like G-protein coupled receptor that in active form binds to one or more chemokines.', 'Category=family. Note: Only those that have been unequivocally shown to activate a G-protein coupled signaling pathway appear on the official IUPHAR list.']",
"term_type": "cell line"
},
{
"accession": "PR:000001094",
"name": "rhodopsin-like G-protein coupled receptor",
"definition": "['A G-protein coupled receptor that contains the 7 transmembrane receptor (rhodopsin family) domain (Pfam:PF00001), which includes 7 transmembrane helices (TMI-TM7) with 3 intracellular loops (IL1-IL3) and 3 extracellular loops (EL1-EL3) between the helices. The amino-terminal region is extracellular and the carboxyl-terminal region is intracellular. Rhodopsin-like G-protein coupled receptors (GPCRs) are unique among the several classes of GPCRs in that most have a very short amino-terminal segment and several characteristic sequence motifs, particularly NSxxNPxxY in TM7 and D/E-R-Y/F between TM3 and loop IL2. Most bind their ligands within a cavity between the TM regions.', 'Category=family. Classification based on GRAFS system. [PMID:12761335]']",
"term_type": "cell line"
},
{
"accession": "PR:000001087",
"name": "adhesion G-protein coupled receptor",
"definition": "['A G-protein coupled receptor with a 7 transmembrane (secretin family) domain (Pfam:PF00002) preceded by an amino-terminal region containing one or more functional domains with adhesion-like motifs.', 'Category=family. Classification based on GRAFS system. [PMID:12761335]']",
"term_type": "cell line"
},
{
"accession": "PR:000001085",
"name": "T-cell surface glycoprotein CD8 beta chain",
"definition": "['A protein that is a translation product of the human CD8B gene or a 1:1 ortholog thereof. CD8 is a transmembrane receptor that is a co-receptor for MHC class-I antigen/T-cell receptor interaction. The most common form of CD8 is composed of a CD8 alpha and a CD8 beta chain.', 'Category=gene.']",
"term_type": "cell line"
},
{
"accession": "PR:000001084",
"name": "T-cell surface glycoprotein CD8 alpha chain",
"definition": "['A protein that is a translation product of the human CD8A gene or a 1:1 ortholog thereof. CD8 is a transmembrane that is a co-receptor for MHC class-I antigen/T-cell receptor interaction. The most common form of CD8 is composed of a CD8 alpha and a CD8 beta chain.', 'Category=gene. Requested by=CL.']",
"term_type": "cell line"
},
{
"accession": "PR:000001083",
"name": "CD2 molecule",
"definition": "['A protein that is a translation product of the human CD2 gene or a 1:1 ortholog thereof.', 'Category=gene. Requested by=CL.']",
"term_type": "cell line"
},
{
"accession": "PR:000001024",
"name": "neural cell adhesion molecule 1",
"definition": "['A neural cell adhesion molecule NCAM that is a translation product of the human NCAM1 gene or a 1:1 ortholog thereof.', 'Category=gene. Requested by=CL.']",
"term_type": "cell line"
},
{
"accession": "PR:000001023",
"name": "neural cell adhesion molecule NCAM",
"definition": "['A neural cell adhesion molecule that is involved in neuronal development, synaptic plasticity, and regeneration.', 'Category=family.']",
"term_type": "cell line"
},
{
"accession": "PR:000001022",
"name": "neural cell adhesion molecule",
"definition": "['A protein with a domain composition consisting of a large extracellular domain, including five Ig-like C2-type domains followed by two copies of the Fibronectin type-III domain (Pfam:PF00041), a single-pass transmembrane domain and a short cytoplasmic C-terminal domain.', 'Category=family.']",
"term_type": "cell line"
},
{
"accession": "PR:000001020",
"name": "CD3 epsilon",
"definition": "['A CD3 subunit with immunoglobulin domain that is a translation product of the human CD3E gene or a 1:1 ortholog thereof.', 'Category=gene. Requested by=CL.']",
"term_type": "cell line"
},
{
"accession": "PR:000001018",
"name": "CD3 subunit with immunoglobulin domain",
"definition": "['A protein with a core domain composition consisting of an extracellular N-terminal domain that adopts an immunoglobulin fold, a transmembrane domain, and an intracellular C-terminal domain with a single copy of the Immunoreceptor tyrosine-based activation motif (Pfam:PF02189) (ITAM). It constitutes the invariant subunit of the T cell antigen receptor (TCR). TCR is a surface receptor on T cells responsible for recognizing MHC-restricted antigens and initiating the cellular immune response.', 'Category=family.']",
"term_type": "cell line"
},
{
"accession": "PR:000001015",
"name": "receptor-type tyrosine-protein phosphatase C isoform CD45RA",
"definition": "['A receptor-type tyrosine-protein phosphatase C isoform CD45R that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08575-8 or a 1:1 ortholog thereof.', 'Category=sequence. Requested by=CL. Note: This isoform includes the region encoded by the variable exon 4(A), and lacks the region encoded by exons 5(B) and 6(C).']",
"term_type": "cell line"
},
{
"accession": "PR:000001013",
"name": "integrin alpha-X",
"definition": "['An integrin alpha with A domain that is a translation product of the human ITGAX gene or a 1:1 ortholog thereof. Integrin alpha-X complexed with beta-2 is a receptor for fibrinogen. It recognizes the sequence GPR in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.', 'Category=gene. Requested by=CL.']",
"term_type": "cell line"
},
{
"accession": "PR:000001012",
"name": "integrin alpha-M",
"definition": "['An integrin alpha with A domain that is a translation product of the human ITGAM gene or a 1:1 ortholog thereof. They constitute subunits of the integrin alpha-M/beta-2 receptor. This receptor is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is also a receptor for fibrinogen, factor X and ICAM1.', 'Category=gene. Requested by=CL.']",
"term_type": "cell line"
},
{
"accession": "PR:000001006",
"name": "receptor-type tyrosine-protein phosphatase C",
"definition": "['A protein that is a translation product of the human PTPRC gene or a 1:1 ortholog thereof. It is composed of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic protein-tyrosine phosphatase domains. Contains 1 to 3 copies of the Fibronectin type III domain (Pfam:PF00041) followed by two copies of the Protein-tyrosine phosphatase (Pfam:PF00102) domain. Receptor-type tyrosine-protein phosphatase C (CD45) regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T and B cells. Multiple isoforms of CD45 (180-235 kDa) can be generated asa result of alternative splicing of three variable exons 4(A), 5(B) and 6(C), encoding sequences at the N-terminal extracellular domain of the molecule.', 'Category=gene. Requested by=CL.']",
"term_type": "cell line"
},
{
"accession": "PR:000001005",
"name": "integrin alpha with A domain",
"definition": "['An integrin alpha that contains an A domain. A hallmark of this class is the presence of a von Willebrand factor type A domain (Pfam:PF00092) (I-domain) of approximately 200 amino acid residues at the N terminus, which confers divalent cation binding properties. Unlike other integrin alpha proteins, they do not undergo proteolytic cleavage.', 'Category=family.']",
"term_type": "cell line"
},
{
"accession": "PR:000001004",
"name": "CD4 molecule",
"definition": "['A protein that is a translation product of the human CD4 gene or a 1:1 ortholog thereof. CD4 is an accessory protein for MHC class-II antigen/T-cell receptor interaction. It is the primary receptor for HIV-1. CD4 has four immunoglobulin-like domains in its extracellular region that share the same structure, but can differ in sequence.', 'Category=gene. Requested by=CL.']",
"term_type": "cell line"
},
{
"accession": "PR:000001003",
"name": "CD34 molecule",
"definition": "['A protein that is a translation product of the human CD34 gene or a 1:1 ortholog thereof. It is a leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. It contains a single-pass transmembrane domain and that show distinct expression on early hematopoietic precursors and vascular-associated tissue. Acts as a scaffold that presents selectin carbohydrate ligands in a clustered, tissue specific manner to allow for higher avidity interactions between leukocytes and endothelial cells during the inflammatory process. In common with related sialomucins (endoglycan and podocalyxin), the extracellular region is dominated by an N-terminal mucin-like domain, which is densely substituted with sialylated O-linked carbohydrates. The mucin-like region is followed by a cysteine-containing and presumably globular domain. This domain may fold into an immunoglobulin-like structure as the positions of 2 of the cysteines are conserved in the C2 set of the immunoglobulin superfamily. The cytoplasmic domain is around 73-76 residues long and highly conserved.', 'Category=gene. Requested by=CL.']",
"term_type": "cell line"
},
{
"accession": "PR:000001002",
"name": "CD19 molecule",
"definition": "['A protein that is a translation product of the human CD19 gene or a 1:1 ortholog thereof. It is composed of an N-terminal extracellular domain containing two Ig-like C2-type (immunoglobulin-like) domains, followed by a single-pass transmembrane segment and a cytoplasmic C-terminal tail. CD19 expression is restricted to members of the B cell lineage. It functions as a co-receptor for B-cell antigen receptor (BCR), regulating signal transduction.', 'Category=gene. Requested by=CL.']",
"term_type": "cell line"
},
{
"accession": "PR:000000001",
"name": "protein",
"definition": "['An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof.', 'The definition above excludes protein complexes, which some also consider a protein. Those who wish to refer to a class representing both senses of the word are directed to CHEBI:36080. Note that the definition allows for experimentally-manipulated genes, and allows for artifically-produced derivatives that mimic those found naturally. Proteins (in the sense defined here) that descended from a common ancestor can be classified into families and superfamilies composed of products of evolutionarily-related genes. The domain architecture of a protein is described by the order of its constituent domains. Proteins with the same domains in the same order are defined as homeomorphic [PRO:WCB].']",
"term_type": "cell line"
}
]
}