{"count":43797,"next":"https://cinder.proteo.info/api/ms_vocab/?format=json&limit=20&offset=41400&ordering=accession","previous":"https://cinder.proteo.info/api/ms_vocab/?format=json&limit=20&offset=41360&ordering=accession","results":[{"accession":"GO:0044782","name":"cilium organization","definition":"['A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.', 'Note that we deem cilium and microtubule-based flagellum to be equivalent.']","term_type":"cell line"},{"accession":"GO:0045058","name":"T cell selection","definition":"['The process in which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation.']","term_type":"cell line"},{"accession":"GO:0045087","name":"innate immune response","definition":"['Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.']","term_type":"cell line"},{"accession":"GO:0045184","name":"establishment of protein localization","definition":"['The directed movement of a protein to a specific location.']","term_type":"cell line"},{"accession":"GO:0045190","name":"isotype switching","definition":"[\"The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus.\", \"Note that IgM and IgD can be coexpressed by B cells via an alternate splicing mechanism, but true recombinational isotype switching to IgD has been demonstrated as well. Note that this term is best used to annotate gene products which are involved in the mechanism of DNA recombination used in isotype switching, like the B cell specific Swap70 factor in the mouse, rather than gene products which promote isotype switching such as cytokines or co-stimulatory molecules, which should instead be annotated to 'regulation of isotype switching ; GO:0045191'.\"]","term_type":"cell line"},{"accession":"GO:0045202","name":"synapse","definition":"['The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.']","term_type":"cell line"},{"accession":"GO:0045321","name":"leukocyte activation","definition":"['A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor.']","term_type":"cell line"},{"accession":"GO:0045453","name":"bone resorption","definition":"['The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products.']","term_type":"cell line"},{"accession":"GO:0045580","name":"regulation of T cell differentiation","definition":"['Any process that modulates the frequency, rate or extent of T cell differentiation.', \"Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.\"]","term_type":"cell line"},{"accession":"GO:0045595","name":"regulation of cell differentiation","definition":"['Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features.']","term_type":"cell line"},{"accession":"GO:0045619","name":"regulation of lymphocyte differentiation","definition":"['Any process that modulates the frequency, rate or extent of lymphocyte differentiation.', \"Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.\"]","term_type":"cell line"},{"accession":"GO:0046394","name":"carboxylic acid biosynthetic process","definition":"['The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.']","term_type":"cell line"},{"accession":"GO:0046483","name":"heterocycle metabolic process","definition":"['The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).']","term_type":"cell line"},{"accession":"GO:0046649","name":"lymphocyte activation","definition":"['A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor.']","term_type":"cell line"},{"accession":"GO:0046717","name":"acid secretion","definition":"['The controlled release of acid by a cell or a tissue.']","term_type":"cell line"},{"accession":"GO:0046849","name":"bone remodeling","definition":"['The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis.']","term_type":"cell line"},{"accession":"GO:0046879","name":"hormone secretion","definition":"['The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells.']","term_type":"cell line"},{"accession":"GO:0046903","name":"secretion","definition":"['The controlled release of a substance by a cell or a tissue.']","term_type":"cell line"},{"accession":"GO:0046907","name":"intracellular transport","definition":"['The directed movement of substances within a cell.']","term_type":"cell line"},{"accession":"GO:0046942","name":"carboxylic acid transport","definition":"['The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).']","term_type":"cell line"}]}