{"count":43797,"next":"https://cinder.proteo.info/api/ms_vocab/?format=json&limit=20&offset=42580","previous":"https://cinder.proteo.info/api/ms_vocab/?format=json&limit=20&offset=42540","results":[{"accession":"PR:000001004","name":"CD4 molecule","definition":"['A protein that is a translation product of the human CD4 gene or a 1:1 ortholog thereof. CD4 is an accessory protein for MHC class-II antigen/T-cell receptor interaction. It is the primary receptor for HIV-1. CD4 has four immunoglobulin-like domains in its extracellular region that share the same structure, but can differ in sequence.', 'Category=gene. Requested by=CL.']","term_type":"cell line"},{"accession":"PR:000001005","name":"integrin alpha with A domain","definition":"['An integrin alpha that contains an A domain. A hallmark of this class is the presence of a von Willebrand factor type A domain (Pfam:PF00092) (I-domain) of approximately 200 amino acid residues at the N terminus, which confers divalent cation binding properties. Unlike other integrin alpha proteins, they do not undergo proteolytic cleavage.', 'Category=family.']","term_type":"cell line"},{"accession":"PR:000001006","name":"receptor-type tyrosine-protein phosphatase C","definition":"['A protein that is a translation product of the human PTPRC gene or a 1:1 ortholog thereof. It is composed of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic protein-tyrosine phosphatase domains. Contains 1 to 3 copies of the Fibronectin type III domain (Pfam:PF00041) followed by two copies of the Protein-tyrosine phosphatase (Pfam:PF00102) domain. Receptor-type tyrosine-protein phosphatase C (CD45) regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T and B cells. Multiple isoforms of CD45 (180-235 kDa) can be generated asa result of alternative splicing of three variable exons 4(A), 5(B) and 6(C), encoding sequences at the N-terminal extracellular domain of the molecule.', 'Category=gene. Requested by=CL.']","term_type":"cell line"},{"accession":"PR:000001012","name":"integrin alpha-M","definition":"['An integrin alpha with A domain that is a translation product of the human ITGAM gene or a 1:1 ortholog thereof. They constitute subunits of the integrin alpha-M/beta-2 receptor. This receptor is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is also a receptor for fibrinogen, factor X and ICAM1.', 'Category=gene. Requested by=CL.']","term_type":"cell line"},{"accession":"PR:000001013","name":"integrin alpha-X","definition":"['An integrin alpha with A domain that is a translation product of the human ITGAX gene or a 1:1 ortholog thereof. Integrin alpha-X complexed with beta-2 is a receptor for fibrinogen. It recognizes the sequence GPR in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.', 'Category=gene. Requested by=CL.']","term_type":"cell line"},{"accession":"PR:000001015","name":"receptor-type tyrosine-protein phosphatase C isoform CD45RA","definition":"['A receptor-type tyrosine-protein phosphatase C isoform CD45R that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08575-8 or a 1:1 ortholog thereof.', 'Category=sequence. Requested by=CL. Note: This isoform includes the region encoded by the variable exon 4(A), and lacks the region encoded by exons 5(B) and 6(C).']","term_type":"cell line"},{"accession":"PR:000001018","name":"CD3 subunit with immunoglobulin domain","definition":"['A protein with a core domain composition consisting of an extracellular N-terminal domain that adopts an immunoglobulin fold, a transmembrane domain, and an intracellular C-terminal domain with a single copy of the Immunoreceptor tyrosine-based activation motif (Pfam:PF02189) (ITAM). It constitutes the invariant subunit of the T cell antigen receptor (TCR). TCR is a surface receptor on T cells responsible for recognizing MHC-restricted antigens and initiating the cellular immune response.', 'Category=family.']","term_type":"cell line"},{"accession":"PR:000001020","name":"CD3 epsilon","definition":"['A CD3 subunit with immunoglobulin domain that is a translation product of the human CD3E gene or a 1:1 ortholog thereof.', 'Category=gene. Requested by=CL.']","term_type":"cell line"},{"accession":"PR:000001022","name":"neural cell adhesion molecule","definition":"['A protein with a domain composition consisting of a large extracellular domain, including five Ig-like C2-type domains followed by two copies of the Fibronectin type-III domain (Pfam:PF00041), a single-pass transmembrane domain and a short cytoplasmic C-terminal domain.', 'Category=family.']","term_type":"cell line"},{"accession":"PR:000001023","name":"neural cell adhesion molecule NCAM","definition":"['A neural cell adhesion molecule that is involved in neuronal development, synaptic plasticity, and regeneration.', 'Category=family.']","term_type":"cell line"},{"accession":"PR:000001024","name":"neural cell adhesion molecule 1","definition":"['A neural cell adhesion molecule NCAM that is a translation product of the human NCAM1 gene or a 1:1 ortholog thereof.', 'Category=gene. Requested by=CL.']","term_type":"cell line"},{"accession":"PR:000001083","name":"CD2 molecule","definition":"['A protein that is a translation product of the human CD2 gene or a 1:1 ortholog thereof.', 'Category=gene. Requested by=CL.']","term_type":"cell line"},{"accession":"PR:000001084","name":"T-cell surface glycoprotein CD8 alpha chain","definition":"['A protein that is a translation product of the human CD8A gene or a 1:1 ortholog thereof. CD8 is a transmembrane that is a co-receptor for MHC class-I antigen/T-cell receptor interaction. The most common form of CD8 is composed of a CD8 alpha and a CD8 beta chain.', 'Category=gene. Requested by=CL.']","term_type":"cell line"},{"accession":"PR:000001085","name":"T-cell surface glycoprotein CD8 beta chain","definition":"['A protein that is a translation product of the human CD8B gene or a 1:1 ortholog thereof. CD8 is a transmembrane receptor that is a co-receptor for MHC class-I antigen/T-cell receptor interaction. The most common form of CD8 is composed of a CD8 alpha and a CD8 beta chain.', 'Category=gene.']","term_type":"cell line"},{"accession":"PR:000001087","name":"adhesion G-protein coupled receptor","definition":"['A G-protein coupled receptor with a 7 transmembrane (secretin family) domain (Pfam:PF00002) preceded by an amino-terminal region containing one or more functional domains with adhesion-like motifs.', 'Category=family. Classification based on GRAFS system. [PMID:12761335]']","term_type":"cell line"},{"accession":"PR:000001094","name":"rhodopsin-like G-protein coupled receptor","definition":"['A G-protein coupled receptor that contains the 7 transmembrane receptor (rhodopsin family) domain (Pfam:PF00001), which includes 7 transmembrane helices (TMI-TM7) with 3 intracellular loops (IL1-IL3) and 3 extracellular loops (EL1-EL3) between the helices. The amino-terminal region is extracellular and the carboxyl-terminal region is intracellular. Rhodopsin-like G-protein coupled receptors (GPCRs) are unique among the several classes of GPCRs in that most have a very short amino-terminal segment and several characteristic sequence motifs, particularly NSxxNPxxY in TM7 and D/E-R-Y/F between TM3 and loop IL2. Most bind their ligands within a cavity between the TM regions.', 'Category=family. Classification based on GRAFS system. [PMID:12761335]']","term_type":"cell line"},{"accession":"PR:000001128","name":"chemokine receptor","definition":"['A rhodopsin-like G-protein coupled receptor that in active form binds to one or more chemokines.', 'Category=family. Note: Only those that have been unequivocally shown to activate a G-protein coupled signaling pathway appear on the official IUPHAR list.']","term_type":"cell line"},{"accession":"PR:000001197","name":"chemokine receptor CCR1/3/1L","definition":"['A chemokine receptor that is a translation product of the human CCR1 or CCR3 genes, the mouse CCR1L1 gene, 1:1 orthologs thereof, or a semi-ortholog thereof.', 'Category=family.']","term_type":"cell line"},{"accession":"PR:000001203","name":"C-C chemokine receptor type 7","definition":"['A chemokine receptor that is a translation product of the human CCR7 gene or a 1:1 ortholog thereof. The preferred ligands are CCL19 and CCL21.', 'Category=gene. Requested by=CL.']","term_type":"cell line"},{"accession":"PR:000001255","name":"C-C chemokine receptor type 3","definition":"['A chemokine receptor CCR1/3/1L that is a translation product of the human CCR3 gene or a 1:1 ortholog thereof.', 'Category=gene. Requested by=CL.']","term_type":"cell line"}]}