{"count":43797,"next":"https://cinder.proteo.info/api/ms_vocab/?format=json&limit=20&offset=660","previous":"https://cinder.proteo.info/api/ms_vocab/?format=json&limit=20&offset=620","results":[{"accession":"CL:0000786","name":"plasma cell","definition":"['A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin.', 'Plasma cells develop in the spleen and migrate to the bone marrow. Plasma cells are also reportedly CD5-negative, CD10-negative, CD19-positive, CD20-negative, CD21-negative, CD22-negative, CD23-negative, CD24-negative, CD25-negative, CD27-positive, CD34-negative, CD38-positive, CD40-positive, CD43-positive, CD45-positive, CD48-positive, CD53-low, CD80-negative, CD81-positive, CD86-positive, CD95-positive, CD196-negative, CD229-positive, CD270-positive, CD352-positive, CD361-positive, and IgD-negative. Transcription factors: BLIMP1-positive, IRF4-positive, PAX5-negative, SpiB-negative, Ets1-negative, and XBP1-positive.']","term_type":"cell line"},{"accession":"CL:0000789","name":"alpha-beta T cell","definition":"['A T cell that expresses an alpha-beta T cell receptor complex.']","term_type":"cell line"},{"accession":"CL:0000790","name":"immature alpha-beta T cell","definition":"['An alpha-beta T cell that has an immature phenotype and has not completed T cell selection.']","term_type":"cell line"},{"accession":"CL:0000791","name":"mature alpha-beta T cell","definition":"['A alpha-beta T cell that has a mature phenotype.']","term_type":"cell line"},{"accession":"CL:0000792","name":"CD4-positive, CD25-positive, alpha-beta regulatory T cell","definition":"['A CD4-positive, CD25-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release.', \"This cell type is compatible with the HIPC Lyoplate markers for 'Treg'.  The inclusion of CD127lo in the logical definition is compatible with both human and mouse T cells of this subtype.\"]","term_type":"cell line"},{"accession":"CL:0000805","name":"immature single positive thymocyte","definition":"['A thymocyte that has the phenotype CD4-negative, CD8-positive, CD44-negative, CD25-negative, and pre-TCR-positive.', 'Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and rearranging the T cell receptor alpha chain and expressing the CD8 coreceptor. This stage comes between the DN4 and DP stages.']","term_type":"cell line"},{"accession":"CL:0000806","name":"DN2 thymocyte","definition":"['A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive.', \"Note that this type of thymocyte is at the earliest stage of T cell receptor rearrangement of the beta, gamma, and delta T cell receptor chains. Also, there is growing evidence that molecular markers characterizing double negative thymocytes are different across species, especially in mouse versus human thymus. If in doubt, please consider using CL:0002489 'double negative thymocyte'.\"]","term_type":"cell line"},{"accession":"CL:0000807","name":"DN3 thymocyte","definition":"['A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, and CD25-positive and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain.', \"There is growing evidence that molecular markers characterizing double negative thymocytes are different across species, especially in mouse versus human thymus. If in doubt, please consider using CL:0002489 'double negative thymocyte'.\"]","term_type":"cell line"},{"accession":"CL:0000808","name":"DN4 thymocyte","definition":"['A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive.', \"Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and beginning to rearrange the T cell receptor alpha chain. There is growing evidence that molecular markers characterizing double negative thymocytes are different across species, especially in mouse versus human thymus. If in doubt, please consider using CL:0002489 'double negative thymocyte'.\"]","term_type":"cell line"},{"accession":"CL:0000809","name":"double-positive, alpha-beta thymocyte","definition":"['A thymocyte expressing the alpha-beta T cell receptor complex as well as both the CD4 and CD8 coreceptors.', 'Thymocytes of this stage are undergoing positive and negative selection.']","term_type":"cell line"},{"accession":"CL:0000810","name":"CD4-positive, alpha-beta thymocyte","definition":"['An immature alpha-beta T cell that is located in the thymus and is CD4-positive and CD8-negative.']","term_type":"cell line"},{"accession":"CL:0000815","name":"regulatory T cell","definition":"['A T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release.', 'This cell type may express FoxP3 and CD25 and secretes IL-10 and TGF-beta.']","term_type":"cell line"},{"accession":"CL:0000816","name":"immature B cell","definition":"['An immature B cell is a B cell that has the phenotype surface IgM-positive and surface IgD-negative, and have not undergone class immunoglobulin class switching or peripheral encounter with antigen and activation.', 'Immature B cells are also reportedly CD5-positive, CD10-positive, CD19-positive, CD20-positive, CD21-positive, CD22-positive, CD24-positive, CD25-negative, CD27-negative, CD34-negative, CD38-positive, CD40-positive, CD43-negative, CD45-positive, CD48-positive, CD53-positive, CD79a-positive, CD80-negative, CD81-positive, CD86-negative, CD95-negative, CD127-negative, CD138-negative, CD185-positive, CD196-positive, MHCII/HLA-DR-positive, RAG-positive, TdT-negative, Vpre-B-negative, and preBCR-negative. Transcription factors expressed: Pax5-positive.']","term_type":"cell line"},{"accession":"CL:0000817","name":"precursor B cell","definition":"['A precursor B cell is a B cell with the phenotype CD10-positive.']","term_type":"cell line"},{"accession":"CL:0000818","name":"transitional stage B cell","definition":"['An immature B cell of an intermediate stage between the pre-B cell stage and the mature naive stage with the phenotype surface IgM-positive and CD19-positive, and are subject to the process of B cell selection. A transitional B cell migrates from the bone marrow into the peripheral circulation, and then to the spleen.', \"This cell type is compatible with the HIPC Lyoplate markers for 'transitional B cell'.\"]","term_type":"cell line"},{"accession":"CL:0000825","name":"pro-NK cell","definition":"['A lymphoid progenitor cell that is committed to the natural killer cell lineage, expressing CD122 (IL-15) receptor, but lacking many of the phenotypic characteristics of later stages of natural killer cell development such as expression of NK activating and inhibitory molecules. In human this cell has the phenotype CD34-positive, CD45RA-positive, CD10-positive, CD117-negative, and CD161 negative.', 'Most markers only described for human pro NK cells.']","term_type":"cell line"},{"accession":"CL:0000826","name":"pro-B cell","definition":"['A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs.', 'Human pro-B cells are reportedly CD10-positive, CD22-positive, CD34-positive, CD38-positive, CD45-low, CD48-positive, CD79a-positive, CD127-positive, CD184-positive, RAG-positive, TdT-positive, Vpre-B-positive, pre-BCR-negative, IgD-negative, and IgM-negative. Transcription factors expressed: Pax5-positive, EBF-positive, E2A-negative, Ikaros-negative, and PU.1-negative.']","term_type":"cell line"},{"accession":"CL:0000827","name":"pro-T cell","definition":"['A lymphoid progenitor cell of the T cell lineage, with some lineage specific marker expression, but not yet fully committed to the T cell lineage.']","term_type":"cell line"},{"accession":"CL:0000829","name":"basophilic myeloblast","definition":"['A myeloblast committed to the basophil lineage.']","term_type":"cell line"},{"accession":"CL:0000831","name":"mast cell progenitor","definition":"['A progenitor cell of the mast cell lineage. Markers for this cell are FceRIa-low, CD117-positive, CD9-positive, T1/ST2-positive, SCA1-negative, and lineage-negative.', 'MCP are CD16-positive, CD32-positive, CD34-positive, CD45-positive, integrin beta-7-positive, and lin-negative (CD2, CD3e, CD4, CD5, CD8a, CD14, CD19, CD20, CD27, integrin alpha-M, ly6c, ly6g, NCAM-1, and ter119). These cells also express the transcription factors GATA-1, GATA-2, and MITF, but not C/EBPa.']","term_type":"cell line"}]}