{"count":543,"next":"https://cinder.proteo.info/api/subcellular_locations/?format=json&limit=20&offset=120","previous":"https://cinder.proteo.info/api/subcellular_locations/?format=json&limit=20&offset=80","results":[{"location_identifier":"Esterosome membrane.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0108","definition":"The membrane surrounding the esterosome, a crystalline inclusion body is a vesicle filled with crystals of proteins showing sequence similarities with various esterases. ","synonyms":"Esterosomal membrane.; ","content":"Cytoplasmic vesicle, esterosome membrane.","is_a":"Cytoplasmic vesicle membrane.; ","part_of":"Esterosome.; Endomembrane system.; ","keyword":null,"gene_ontology":"GO:0033118; esterosome membrane; ","annotation":null,"references":null,"links":null},{"location_identifier":"Esterosome.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0109","definition":"The esterosome is a crystalline inclusion body. This vesicle is filled with crystals of proteins showing sequence similarities with various esterases. The enclosing membrane has the characteristics of RER. ","synonyms":null,"content":"Cytoplasmic vesicle, esterosome.","is_a":"Cytoplasmic vesicle.; ","part_of":null,"keyword":null,"gene_ontology":"GO:0033117; esterosome; ","annotation":null,"references":null,"links":null},{"location_identifier":"Etioplast.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0110","definition":"The etioplast is a plastid found in plants grown in the dark. ","synonyms":null,"content":"Plastid, etioplast.","is_a":"Plastid.; ","part_of":null,"keyword":null,"gene_ontology":"GO:0009513; etioplast; ","annotation":null,"references":null,"links":null},{"location_identifier":"Extracellular matrix.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0111","definition":"The extracellular matrix (ECM) is a vague term used to refer to all the material surrounding cells in a multicellular organism, except circulating fluids such as blood or lymph. In some cases, the ECM accounts for more of the organism's bulk than its cells. In plants, arthropods and fungi the ECM is primarily composed of nonliving material such as cellulose or chitin. In vertebrates the ECM consists of a complex network including the basement membrane, collage, elastin, proteoglycans and hyaluronan. ","synonyms":"Proteinaceous extracellular matrix.; ","content":"Secreted, extracellular space, extracellular matrix.","is_a":null,"part_of":"Extracellular space.; ","keyword":"KW-0272","gene_ontology":null,"annotation":null,"references":null,"links":null},{"location_identifier":"Extracellular space.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0112","definition":"The extracellular space is the space outside of the cell membrane but part of a multicellular organism. The term is typically used for a secreted protein that remains associated with the cell, e.g. as part of the extracellular matrix. It is not used for a protein that is secreted into the blood stream (or other body fluids) of eukaryotic, multicellular organisms, such as insulin or fibroblast growth factors. ","synonyms":"Intercellular space.; ","content":"Secreted, extracellular space.","is_a":null,"part_of":"Secreted.; ","keyword":null,"gene_ontology":"GO:0005576; extracellular region; ","annotation":null,"references":null,"links":null},{"location_identifier":"Fimbrium.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0113","definition":"A fimbrium or pilus is a hair-like, non-flagellar, polymeric filamentous appendage that extend from the bacterial or archaeal cell surface, such as type 1 pili, P-pili, type IV pili or curli. Pili perform a variety of functions, including surface adhesion, motility, cell-cell interactions, biofilm formation, conjugation, DNA uptake, and twitching motility. ","synonyms":"Fimbria; Pili; Pilus.; ","content":"Fimbrium.","is_a":null,"part_of":null,"keyword":"KW-0281","gene_ontology":"GO:0009289; pilus; ","annotation":null,"references":null,"links":null},{"location_identifier":"Flagellum axoneme.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0114","definition":"The flagellum axoneme is the most prominent structural component of the flagellum, which is a long whip-like or feathery structure which propels the cell through a liquid medium. The flagellum axoneme consists of a characteristic axial '9+2' microtubular array. ","synonyms":"Flagellar axoneme.; ","content":"Cytoplasm, cytoskeleton, flagellum axoneme.","is_a":"Cilium axoneme.; ","part_of":"Flagellum.; ","keyword":null,"gene_ontology":null,"annotation":null,"references":null,"links":null},{"location_identifier":"Flagellum membrane.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0115","definition":"The portion of the cell membrane surrounding the flagellum, a long whip-like or feathery structure which propels the cell through a liquid medium. ","synonyms":"Flagellar membrane.; ","content":"Cell projection, cilium, flagellum membrane.","is_a":"Cilium membrane.; ","part_of":"Flagellum.; ","keyword":null,"gene_ontology":null,"annotation":null,"references":null,"links":null},{"location_identifier":"Flagellar pocket.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0116","definition":"The flagellar pocket is a structure found in trypanosomes. The flagellar pocket is formed by an invagination in the plasma membrane where the flagellum emerges from the cell body. This pocket provides the portal through which most of the dynamic interactions with the host occur. ","synonyms":null,"content":"Flagellar pocket.","is_a":null,"part_of":null,"keyword":null,"gene_ontology":"GO:0020016; ciliary pocket; ","annotation":null,"references":null,"links":null},{"location_identifier":"Flagellum.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0117","definition":"The flagellum is a long whip-like or feathery structure which propels the cell through a liquid medium. This motile cilium is produced by the unicellular eukaryotes, and by the motile male gametes of many eukaryotic organisms. The flagella commonly have a characteristic axial '9+2' microtubular array (axoneme) and bends are generated along the length of the flagellum by restricted sliding of the nine outer doublets. ","synonyms":"Flagella; Motile cilia; Motile cilium; Undulipodia; Undulipodium.; ","content":"Cell projection, cilium, flagellum.","is_a":"Cilium.; ","part_of":null,"keyword":"KW-0282","gene_ontology":"GO:0031514; motile cilium; ","annotation":null,"references":null,"links":"http://www.ciliome.com; "},{"location_identifier":"Focal adhesion.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0118","definition":"Focal adhesions are sites of tightest adhesion made to the underlying extracellular matrix by cells in culture. They serve a structural role, linking the ECM on the outside to the actin cytoskeleton on the inside. In addition, they are sites of signal transduction, initiating signaling pathways in response to adhesion. Focal adhesions are formed around a transmembrane core of an alpha-beta integrin heterodimer, which binds to a component of the extracellular matrix on its extracellular region, constitutes the site of anchorage of the actin cytoskeleton to the cytoplasmic side of the membrane, and mediates various intracellular signaling pathways. ","synonyms":null,"content":"Cell junction, focal adhesion.","is_a":"Cell junction.; ","part_of":null,"keyword":null,"gene_ontology":"GO:0005925; focal adhesion; ","annotation":"Add \"Cell membrane\" if the protein is clearly associated with the membrane. ","references":null,"links":"http://www-cellbio.med.unc.edu/grad/depttest/burridge.htm; "},{"location_identifier":"Forespore.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0119","definition":"Sporulation leads to the formation of an asymmetrically positioned division septum (the polar septum) which divides the developing cell into two adjacent, but unequal-sized compartments called the forespore (the smaller cell) and the mother cell. ","synonyms":"Prespore.; ","content":"Forespore.","is_a":null,"part_of":null,"keyword":null,"gene_ontology":"GO:0042763; intracellular immature spore; ","annotation":null,"references":"PubMed=15753026; DOI=10.1016/j.cub.2005.02.041;; ","links":null},{"location_identifier":"Forespore inner membrane.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0120","definition":"The inner membrane of the smaller compartment, the forespore, of a sporulating cell. ","synonyms":"Prespore inner membrane.; ","content":"Forespore inner membrane.","is_a":"Forespore membrane.; ","part_of":"Forespore.; ","keyword":null,"gene_ontology":null,"annotation":null,"references":null,"links":null},{"location_identifier":"Forespore intermembrane space.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0121","definition":"The intermembrane space between the inner and outer forespore membranes. ","synonyms":"Prespore intermembrane space.; ","content":"Forespore intermembrane space.","is_a":null,"part_of":"Forespore.; ","keyword":null,"gene_ontology":null,"annotation":null,"references":null,"links":null},{"location_identifier":"Forespore membrane.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0122","definition":"The membrane surrounding a forespore. This term is used when it is not known if the protein is found in or associated with the inner or outer forespore membrane. ","synonyms":"Prespore membrane.; ","content":"Forespore membrane.","is_a":"Membrane.; ","part_of":"Forespore.; ","keyword":null,"gene_ontology":null,"annotation":null,"references":null,"links":null},{"location_identifier":"Forespore outer membrane.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0123","definition":"The outer membrane of the smaller compartment, the forespore, of a sporulating cell. ","synonyms":"Prespore outer membrane.; ","content":"Forespore outer membrane.","is_a":"Forespore membrane.; ","part_of":"Forespore.; ","keyword":null,"gene_ontology":null,"annotation":null,"references":null,"links":null},{"location_identifier":"Gap junction.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0124","definition":"A gap junction (GJ) is a communicating junction between certain cell types that allows the passive passage of ions and small molecules providing a direct pathway for electrical and metabolic signaling. In vertebrates GJs are patches of channels, each cell membrane contains a 'hemichannel', so that each GJ channel is composed of two hemichannels (connexons), which in turn are composed of six membrane proteins (connexins (Cxs)). In invertebrates, GJ channels are formed by another large family of integral membrane proteins, the innexins. GJ exists in all metazoans (multi-cellular organisms) and in almost all cell types in these organisms. ","synonyms":"Connexons.; ","content":"Cell junction, gap junction.","is_a":"Cell junction.; ","part_of":null,"keyword":"KW-0303","gene_ontology":"GO:0005921; gap junction; ","annotation":"Add \"Cell membrane\" if the protein is clearly associated with the membrane. ","references":null,"links":null},{"location_identifier":"Gas vesicle.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0125","definition":"Gas vesicles (GV) are hollow, watertight, gas-permeable proteinaceous nanostructures found in some microorganisms. During planktonic growth they allow positioning of the organism at a favorable depth for light or nutrient acquisition. By regulating their relative GV content, aquatic microbes can perform vertical migrations. The GV is impermeable to liquid water but is highly permeable to gases and is normally filled with air. As they scatter light, they may also protect against UV light. Two main proteins are present in the gas vesicle: GvpA, an extremely hydrophobic protein which makes the ribs that form the structure, and GvpC, which binds to the outside of the ribs, helps shape the GV and stiffens it against collapse. ","synonyms":null,"content":"Gas vesicle.","is_a":null,"part_of":null,"keyword":"KW-0304","gene_ontology":"GO:0031411; gas vesicle; ","annotation":null,"references":null,"links":null},{"location_identifier":"Gas vesicle shell.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0126","definition":"The protein shell surrounding a gas vesicle. ","synonyms":null,"content":"Gas vesicle shell.","is_a":null,"part_of":"Gas vesicle.; ","keyword":null,"gene_ontology":null,"annotation":null,"references":null,"links":null},{"location_identifier":"Gem.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0127","definition":"Gems are nuclear bodies, often found paired or juxtaposed to Cajal bodies, called gems for \"gemini of CBs\". It is not clear if Cajal bodes and gems are distinct nuclear bodies or if they should be considered as two manifestations of the same structure. ","synonyms":null,"content":"Nucleus, gem.","is_a":"Nuclear body.; ","part_of":"Nucleus.; ","keyword":null,"gene_ontology":"GO:0097504; Gemini of coiled bodies; ","annotation":null,"references":null,"links":null}]}