{"count":543,"next":"https://cinder.proteo.info/api/subcellular_locations/?format=json&limit=20&offset=120&ordering=-location_identifier","previous":"https://cinder.proteo.info/api/subcellular_locations/?format=json&limit=20&offset=80&ordering=-location_identifier","results":[{"location_identifier":"Presynaptic active zone membrane.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0527","definition":"The membrane portion of the presynaptic active zone that allows presynaptic vesicles to dock, fuse, and, ultimately, release neurotransmitter into the synaptic cleft. ","synonyms":null,"content":"Presynaptic active zone membrane.","is_a":null,"part_of":"Presynaptic cell membrane.; Presynaptic active zone.; ","keyword":null,"gene_ontology":"GO:0048787; presynaptic active zone membrane; ","annotation":null,"references":null,"links":null},{"location_identifier":"Presynaptic active zone.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0519","definition":"The active zone is the region that lies at the interface between the presynaptic terminal and the synaptic cleft and mediates neurotransmitter release. Consists of an electron dense protein network called the cytomatrix at the active zone (CAZ) that is tightly anchored to the presynaptic membrane, and precisely aligned with post- synaptic receptors. CAZ docks and fuses synaptic vesicles, recruits voltage-gated Ca(2+) channels to the presynaptic membrane to allow fast synchronous excitation/release coupling and mediates short- and long-term presynaptic plasticity. ","synonyms":null,"content":"Presynaptic active zone.","is_a":null,"part_of":"Presynapse.; ","keyword":null,"gene_ontology":"GO:0048786; presynaptic active zone; ","annotation":null,"references":null,"links":null},{"location_identifier":"Presynapse.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0516","definition":"In the synapse, the specialized axon's terminal end of the presynaptic cell that contains the specialized apparatus necessary to release neurotransmitters to the synaptic cleft. ","synonyms":"Axon terminal; Pre-synapse; Presynaptic bouton; Presynaptic region;; Presynaptic terminal.; ","content":"Presynapse.","is_a":null,"part_of":"Synapse.; Axon.; ","keyword":null,"gene_ontology":"GO:0098793; presynapse; ","annotation":null,"references":null,"links":null},{"location_identifier":"Preautophagosomal structure membrane.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0221","definition":"The membrane surrounding the pre-autophagosomal structure. ","synonyms":"PAS membrane; Pre-autophagosomal structure membrane.; ","content":"Preautophagosomal structure membrane.","is_a":"Membrane.; ","part_of":"Endomembrane system.; Preautophagosomal structure.; ","keyword":null,"gene_ontology":"GO:0034045; phagophore assembly site membrane; ","annotation":null,"references":null,"links":null},{"location_identifier":"Preautophagosomal structure.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0220","definition":"The pre-autophagosomal structure is the potential site of organization for autophagosome formation located near the vacuole. ","synonyms":"PAS; Phagophore assembly site; Pre-autophagosomal structure.; ","content":"Preautophagosomal structure.","is_a":null,"part_of":null,"keyword":null,"gene_ontology":"GO:0000407; phagophore assembly site; ","annotation":null,"references":null,"links":null},{"location_identifier":"Postsynaptic recycling endosome membrane.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0533","definition":"The membrane surrounding a postsynaptic recycling endosome ","synonyms":null,"content":"Postsynaptic recycling endosome membrane.","is_a":"Membrane.; ","part_of":"Postsynaptic recycling endosome.; ","keyword":null,"gene_ontology":"GO:0098944; postsynaptic recycling endosome membrane; ","annotation":null,"references":null,"links":null},{"location_identifier":"Postsynaptic recycling endosome.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0524","definition":"A recycling endosome of the postsynapse. It is involved in recycling of neurotransmitter receptors to the postsynaptic membrane and serves as intracellular reserve pools of neurotransmitter receptors. In some cases at least, this recycling is activated by postsynaptic signalling and so can play a role in long term potentiation. ","synonyms":null,"content":"Postsynaptic recycling endosome.","is_a":"Recycling endosome.; Postsynaptic endosome.; ","part_of":"Postsynapse.; ","keyword":null,"gene_ontology":"GO:0098837; postsynaptic recycling endosome; ","annotation":null,"references":null,"links":null},{"location_identifier":"Postsynaptic endosome.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0522","definition":"An endosomal compartment that is part of the postsynapse. The endosomal pathway in postsynapses and dendrites is essential for membrane receptor trafficking and proper synaptic function and plasticity. Only early and recycling endosomes are typically present in the postsynapse. ","synonyms":"postsynaptic endosome.; ","content":"Postsynaptic endosome.","is_a":"Endosome.; ","part_of":"Postsynapse.; ","keyword":null,"gene_ontology":"GO:0098845; postsynaptic endosome; ","annotation":null,"references":null,"links":null},{"location_identifier":"Postsynaptic endocytic zone.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0528","definition":"Stably positioned sites of clathrin adjacent to the postsynaptic density (PSD). The physical link with the PSD ensures localized endocytosis and recycling by recapturing and maintaining a proximate pool of cycling postsynaptic receptors. ","synonyms":null,"content":"Postsynaptic endocytic zone.","is_a":null,"part_of":"Postsynapse.; ","keyword":null,"gene_ontology":"GO:0098843; postsynaptic endocytic zone; ","annotation":null,"references":null,"links":null},{"location_identifier":"Postsynaptic early endosome membrane.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0534","definition":"The membrane surrounding a postsynaptic early endosome ","synonyms":null,"content":"Postsynaptic early endosome membrane.","is_a":"Membrane.; ","part_of":"Postsynaptic early endosome.; ","keyword":null,"gene_ontology":"GO:0098896; postsynaptic early endosome membrane; ","annotation":null,"references":null,"links":null},{"location_identifier":"Postsynaptic early endosome.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0523","definition":"An early endosome of the postsynapse. It acts as the major sorting station on the endocytic pathway, targeting neurotransmitter receptors for degredation or recycling. ","synonyms":null,"content":"Postsynaptic early endosome.","is_a":"Early endosome.; ","part_of":"Postsynaptic endosome.; ","keyword":null,"gene_ontology":"GO:0098842; postsynaptic early endosome; ","annotation":null,"references":null,"links":null},{"location_identifier":"Postsynaptic density membrane.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0520","definition":"The membrane component of the postsynaptic specialization. Part of the postsynaptic membrane attached to the postsynaptic density in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated and organized. ","synonyms":null,"content":"Postsynaptic density membrane.","is_a":null,"part_of":"Postsynaptic cell membrane.; Postsynaptic density.; ","keyword":null,"gene_ontology":"GO:0098839; postsynaptic density membrane; ","annotation":null,"references":null,"links":null},{"location_identifier":"Postsynaptic density.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0297","definition":"The postsynaptic density is a network of proteins within and adjacent to the postsynaptic membrane, consisting of anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components that spatially and functionally organize the neurotransmitter receptors at the synapse. In asymmetric synapses, the postsynaptic density is a thick electron dense network but in symmetric synapses this structure is thinner and not electron dense. ","synonyms":"Postsynaptic specialization; PSD.; ","content":"Postsynaptic density.","is_a":null,"part_of":"Postsynapse.; ","keyword":null,"gene_ontology":"GO:0014069; postsynaptic density; ","annotation":null,"references":null,"links":null},{"location_identifier":"Postsynaptic cell membrane.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0219","definition":"In a chemical synapse, specialized area of the membrane that receives a signal (binds neurotransmitter) from the presynaptic cell and responds via depolarization or hyperpolarization. The postsynaptic membrane is separated from the presynaptic membrane by the synaptic cleft. ","synonyms":"Postsynaptic membrane.; ","content":"Postsynaptic cell membrane.","is_a":"Synaptic cell membrane.; ","part_of":"Postsynapse.; ","keyword":"KW-0628","gene_ontology":"GO:0045211; postsynaptic membrane; ","annotation":null,"references":null,"links":null},{"location_identifier":"Postsynapse.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0515","definition":"The receiving part of a synapse which contains the neurotransmitter- receptor scaffold and signaling machinery to respond to signals from the presynaptic cell. ","synonyms":"Post-synapse; Postsynaptic region; Postsynaptic terminal.; ","content":"Postsynapse.","is_a":null,"part_of":"Synapse.; ","keyword":null,"gene_ontology":"GO:0098794; postsynapse; ","annotation":null,"references":null,"links":null},{"location_identifier":"Porosome.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0218","definition":"The porosome is an actin-regulated dynamic structure at the cell membrane, where membrane-bound secretory vesicles dock and fuse to release their contents. ","synonyms":null,"content":"Cell membrane, porosome.","is_a":null,"part_of":"Cell membrane.; ","keyword":null,"gene_ontology":"GO:0033012; porosome; ","annotation":null,"references":null,"links":null},{"location_identifier":"Pollen coat.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0371","definition":"The relatively impermeable, lipidic layer which surrounds the outer exine layer of a pollen grain. ","synonyms":"Pollenkitt.; ","content":"Secreted, extracellular space, extracellular matrix, pollen coat.","is_a":"Extracellular matrix.; ","part_of":null,"keyword":null,"gene_ontology":"GO:0070505; pollen coat; ","annotation":null,"references":null,"links":null},{"location_identifier":"Podosome membrane.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0296","definition":"The portion of the cell membrane surrounding a podosome. ","synonyms":"Podosomal membrane.; ","content":"Cell projection, podosome membrane.","is_a":null,"part_of":"Cell membrane.; Podosome.; ","keyword":null,"gene_ontology":null,"annotation":null,"references":null,"links":null},{"location_identifier":"Podosome.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0295","definition":"The podosome is a ring-like cell protrusion which mediates cell- extracellular matrix interactions. Podosomes are composed of an actin- bundle core, flanked by a ring containing adhesion proteins connected to the core via dome-like radial actin fibers. Podosomes are rich in actin filaments, matrix-degrading enzymes, focal adhesion molecules and molecules involved in vesicle trafficking. These structures protrudes into the extracellular matrix and are essential for invasion and metastasis. Classical podosomes are highly dynamic structures formed by cell types of monocytic origin, such as macrophages, dendritic cells, and osteoclasts. ","synonyms":null,"content":"Cell projection, podosome.","is_a":"Cell junction.; Cell projection.; ","part_of":null,"keyword":null,"gene_ontology":"GO:0002102; podosome; ","annotation":null,"references":null,"links":null},{"location_identifier":"PML body.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0465","definition":"The PML bodies are dynamic nuclear protein aggregates interspersed between chromatin. These punctate nuclear structures are call PML bodies because the PML gene is essential for their formation. These discrete nuclear foci, 0.2-1.0 micrometer wide, are present in most mammalian cell nuclei and typically number 1 to 30 bodies per nucleus, depending on the cell type, cell-cycle phase and differentiation stage. Recent evidence implies that, although they appear to be uniform, PML-NBs are structurally and functionally heterogeneous and are dynamic structures. ","synonyms":"Kremer body; ND10; Nuclear domains-10; PML-NB; PML-nuclear body;; PML oncogenic domain; Promyelocytic leukaemia nuclear body;; Promyelocytic leukemia nuclear body.; ","content":"Nucleus, PML body.","is_a":"Nuclear body.; ","part_of":"Nucleus.; ","keyword":null,"gene_ontology":"GO:0016605; PML body; ","annotation":null,"references":"PubMed=17928811; DOI=10.1038/nrm2277;; ","links":null}]}