{"count":543,"next":"https://cinder.proteo.info/api/subcellular_locations/?format=json&limit=20&offset=200&ordering=synonyms","previous":"https://cinder.proteo.info/api/subcellular_locations/?format=json&limit=20&offset=160&ordering=synonyms","results":[{"location_identifier":"Inner membrane complex.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0362","definition":"The inner membrane complex, found in apicocomplexan parasites, is composed of flattened membrane cisternae closely associated to the cell membrane. Together, the cell membrane and the IMC form a triple lipid bilayer called the pellicle (or cell wall). ","synonyms":"IMC.; ","content":"Inner membrane complex.","is_a":null,"part_of":"Membrane.; ","keyword":null,"gene_ontology":"GO:0070258; inner membrane pellicle complex; ","annotation":null,"references":null,"links":null},{"location_identifier":"Amyloplast inner membrane.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0013","definition":"The inner membrane of an amyloplast. ","synonyms":"Inner amyloplastic membrane.; ","content":"Plastid, amyloplast inner membrane.","is_a":"Amyloplast membrane.; Plastid inner membrane.; ","part_of":null,"keyword":null,"gene_ontology":"GO:0033098; amyloplast inner membrane; ","annotation":null,"references":null,"links":null},{"location_identifier":"Mitochondrion inner membrane.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0168","definition":"The inner membrane of a mitochondrion is the membrane which separates the mitochondrial matrix from the intermembrane space. ","synonyms":"Inner mitochondrial membrane; Mitochondrial inner membrane.; ","content":"Mitochondrion inner membrane.","is_a":"Mitochondrion membrane.; ","part_of":null,"keyword":"KW-0999","gene_ontology":"GO:0005743; mitochondrial inner membrane; ","annotation":null,"references":null,"links":null},{"location_identifier":"Mitosome inner membrane.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0439","definition":"The inner membrane of a mitosome is the membrane which separates the mitosomal matrix from the intermembrane space. ","synonyms":"Inner mitosomal membrane; Mitosomal inner membrane.; ","content":"Mitosome inner membrane.","is_a":"Mitosome membrane.; ","part_of":null,"keyword":null,"gene_ontology":null,"annotation":null,"references":null,"links":null},{"location_identifier":"Nucleus inner membrane.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0179","definition":"The inner membrane of the nucleus is the membrane which separates the nuclear matrix from the intermembrane space. In mammals, the inner nuclear membrane is associated with heterochromatin and the nuclear lamina. ","synonyms":"Inner nuclear membrane; Nuclear inner membrane.; ","content":"Nucleus inner membrane.","is_a":"Nucleus membrane.; ","part_of":null,"keyword":null,"gene_ontology":"GO:0005637; nuclear inner membrane; ","annotation":null,"references":null,"links":null},{"location_identifier":"Plastid inner membrane.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0211","definition":"The inner membrane of a plastid separates the plastid stroma from the intermembrane space. ","synonyms":"Inner plastidic membrane; Inner plastid membrane;; Plastidic inner membrane.; ","content":"Plastid inner membrane.","is_a":"Plastid membrane.; ","part_of":null,"keyword":"KW-1001","gene_ontology":"GO:0009528; plastid inner membrane; ","annotation":null,"references":null,"links":null},{"location_identifier":"Extracellular space.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0112","definition":"The extracellular space is the space outside of the cell membrane but part of a multicellular organism. The term is typically used for a secreted protein that remains associated with the cell, e.g. as part of the extracellular matrix. It is not used for a protein that is secreted into the blood stream (or other body fluids) of eukaryotic, multicellular organisms, such as insulin or fibroblast growth factors. ","synonyms":"Intercellular space.; ","content":"Secreted, extracellular space.","is_a":null,"part_of":"Secreted.; ","keyword":null,"gene_ontology":"GO:0005576; extracellular region; ","annotation":null,"references":null,"links":null},{"location_identifier":"Invadopodium.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0148","definition":"The invadopodium is a localized and persitent cell protrusion similar to the highly dynamic podosome, but larger. These structures protrudes into the extracellular matrix. Invadopodial protrusions are enriched in integrins, tyrosine kinase signaling machinery, soluble and membrane proteases including matrix metalloproteases, actin and actin- associated proteins. Essential for physiological and pathological cell invasion and metastasis these structures are involved in focalized degradation of the extracellular matrix. Invadopodia form underneath the cell body, often close to the nucleus and proximal to the Golgi complex, and are rarely found at the cell periphery. Their half-life is quite extended. As invadopodia and podosomes are similar in appearance, location and composition, it is likely that a thin line separates these two entities in time and function. ","synonyms":"Invadopodia.; ","content":"Cell projection, invadopodium.","is_a":"Cell junction.; Cell projection.; ","part_of":null,"keyword":null,"gene_ontology":null,"annotation":null,"references":"PubMed=16546558; DOI=10.1016/j.ejcb.2005.09.005;; ","links":null},{"location_identifier":"Interphotoreceptor matrix.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0146","definition":"In vertebrates, the photoreceptors are separated from the retinal pigment epithelium by the subretinal space, which contains a specialized extracellular material referred to as interphotoreceptor matrix. The IPM mediates key interactions between the photoreceptors and RPE including adhesion, phagocytosis, outer segment stability, nutrient exchange, development, and vitamin A trafficking in the visual cycle. ","synonyms":"IPM.; ","content":"Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix.","is_a":"Extracellular matrix.; ","part_of":null,"keyword":null,"gene_ontology":"GO:0033165; interphotoreceptor matrix; ","annotation":null,"references":null,"links":null},{"location_identifier":"Nucleoplasm.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0190","definition":"The nucleoplasm is a highly viscous liquid contained within the nucleus that surrounds the chromosomes and other subnuclear organelles. A network of fibers known as the nuclear matrix can also be found in the nucleoplasm. ","synonyms":"Karyolymph; Karyoplasm.; ","content":"Nucleus, nucleoplasm.","is_a":null,"part_of":"Nucleus.; ","keyword":null,"gene_ontology":"GO:0005654; nucleoplasm; ","annotation":null,"references":null,"links":null},{"location_identifier":"Nucleus envelope.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0178","definition":"The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space. ","synonyms":"Karyotheca; Nuclear envelope; Nucleolemma; Perinuclear envelope.; ","content":"Nucleus envelope.","is_a":null,"part_of":"Nucleus.; ","keyword":null,"gene_ontology":"GO:0005635; nuclear envelope; ","annotation":null,"references":null,"links":null},{"location_identifier":"Kinocilium.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0460","definition":"The kinocilium is an immotile primary cilium that is found at the apical surface of auditory receptor cells. Hair bundles, the mechanosensory device of the sensory hair cells, are composed of height-ranked rows of stereocilia and a single kinocilium that are interconnected by extracellular proteinaceous links. ","synonyms":"Kinocilia.; ","content":"Cell projection, kinocilium.","is_a":"Cilium.; ","part_of":null,"keyword":null,"gene_ontology":"GO:0060091; kinocilium; ","annotation":null,"references":null,"links":null},{"location_identifier":"PML body.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0465","definition":"The PML bodies are dynamic nuclear protein aggregates interspersed between chromatin. These punctate nuclear structures are call PML bodies because the PML gene is essential for their formation. These discrete nuclear foci, 0.2-1.0 micrometer wide, are present in most mammalian cell nuclei and typically number 1 to 30 bodies per nucleus, depending on the cell type, cell-cycle phase and differentiation stage. Recent evidence implies that, although they appear to be uniform, PML-NBs are structurally and functionally heterogeneous and are dynamic structures. ","synonyms":"Kremer body; ND10; Nuclear domains-10; PML-NB; PML-nuclear body;; PML oncogenic domain; Promyelocytic leukaemia nuclear body;; Promyelocytic leukemia nuclear body.; ","content":"Nucleus, PML body.","is_a":"Nuclear body.; ","part_of":"Nucleus.; ","keyword":null,"gene_ontology":"GO:0016605; PML body; ","annotation":null,"references":"PubMed=17928811; DOI=10.1038/nrm2277;; ","links":null},{"location_identifier":"Lamellipodium.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0291","definition":"The lamellipodium is a broad, flat, veil-shaped cell protrusion formed at the leading edge of migrating cells. Lamellipodium contain a branched dendritic network of actin filaments having their barbed ends directed towards the cell membrane. It is associated with ameboid motility (or crawling motility). ","synonyms":"Lamellipodia; Veil.; ","content":"Cell projection, lamellipodium.","is_a":"Cell projection.; ","part_of":null,"keyword":null,"gene_ontology":"GO:0030027; lamellipodium; ","annotation":null,"references":null,"links":null},{"location_identifier":"Neuronal dense core vesicle.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0526","definition":"Dense core vesicle that is part of a neuron. Stores and releases neuropeptides (peptide neurotransmitters) and neurotrophins by exocytosis. Filled with cargo at the Golgi network, they are transported through axons and dendrites to the synapses where the release takes place. They can be found in all parts of neurons, including the soma, dendrites, axonal swellings (varicosities) and synaptic terminals. ","synonyms":"Large dense-core vesicles; Neuronal dense core granule;; Neuronal large dense-core vesicles.; ","content":"Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle.","is_a":"Secretory vesicle.; ","part_of":null,"keyword":null,"gene_ontology":"GO:0098992; neuronal dense core vesicle; ","annotation":null,"references":null,"links":null},{"location_identifier":"Late endosome lumen.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0336","definition":"The late endosomal comaprtment bounded by the membrane of the late endosome. ","synonyms":"Late endosomal lumen.; ","content":"Late endosome lumen.","is_a":"Endosome lumen.; ","part_of":"Late endosome.; ","keyword":null,"gene_ontology":"GO:0031906; late endosome lumen; ","annotation":null,"references":null,"links":null},{"location_identifier":"Late endosome membrane.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0151","definition":"The membrane surrounding the late endosomes. ","synonyms":"Late endosomal membrane.; ","content":"Late endosome membrane.","is_a":"Endosome membrane.; ","part_of":"Late endosome.; ","keyword":null,"gene_ontology":"GO:0031902; late endosome membrane; ","annotation":null,"references":null,"links":null},{"location_identifier":"Lateral cell membrane.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0153","definition":"The portion of the plasma membrane at the lateral side of the cell. ","synonyms":"Lateral plasma membrane.; ","content":"Lateral cell membrane.","is_a":null,"part_of":"Cell membrane.; ","keyword":null,"gene_ontology":"GO:0016328; lateral plasma membrane; ","annotation":null,"references":null,"links":null},{"location_identifier":"Membrane raft.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0370","definition":"Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions. Multiple types of rafts are likely to exist, based both on their lipid and protein composition. ","synonyms":"Lipid microdomain; Lipid raft; Membrane microdomain.; ","content":"Membrane raft.","is_a":null,"part_of":"Endomembrane system.; ","keyword":null,"gene_ontology":"GO:0045121; membrane raft; ","annotation":null,"references":"PubMed=16645198; DOI=10.1194/jlr.E600002-JLR200;; ","links":null},{"location_identifier":"Lysosome lumen.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0156","definition":"The lumen of a lysosome is the volume enclosed within the lysosomal membrane. ","synonyms":"Lysosomal lumen.; ","content":"Lysosome lumen.","is_a":null,"part_of":"Lysosome.; ","keyword":null,"gene_ontology":"GO:0043202; lysosomal lumen; ","annotation":null,"references":null,"links":null}]}