{"count":543,"next":"https://cinder.proteo.info/api/subcellular_locations/?format=json&limit=20&offset=460&ordering=-synonyms","previous":"https://cinder.proteo.info/api/subcellular_locations/?format=json&limit=20&offset=420&ordering=-synonyms","results":[{"location_identifier":"Endoplasmic reticulum-Golgi intermediate compartment.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0098","definition":"The ER-Golgi intermediate compartment is a collection of tubulovesicular membrane clusters in the vicinity of ER exit sites. The ERGIC mediates transport between the endoplasmic reticulum and the Golgi and is the first anterograde/retrograde sorting station in the secretory pathway. ERGIC has not been observed in yeast and plants. ","synonyms":"ERGIC; ER-Golgi intermediate compartment; IC;; Intermediate compartment; Vesiculo-tubular cluster; VTC.; ","content":"Endoplasmic reticulum-Golgi intermediate compartment.","is_a":null,"part_of":null,"keyword":null,"gene_ontology":"GO:0005793; endoplasmic reticulum-Golgi intermediate compartment; ","annotation":"Compartment specific marker: LMAN1/ERGIC-53 (Also called P-58). ","references":null,"links":null},{"location_identifier":"Cell envelope.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0036","definition":"The cell envelope comprises the cell membrane, the cell wall and an outer membrane if present. In bacteria with 1 membrane (Gram-positive) the cell envelope consists of the cytoplasmic membrane, cell wall and capsule. In bacteria with 2 membranes (Gram-negative) the envelope consists of the cytoplasmic membrane, cell wall, periplasmic space, outer membrane and capsule. The archaeal cell envelope generally consists of single membrane covered by a surface layer (S-layer). Ignicoccus species exceptionally have an outer membrane which encloses a large periplasmic space. Extreme thermophiles and acidophiles have tetraether type glycerophospholipids with C40 isoprenoid chains. The yeast cell envelope is a protecting capsule which consists of the cytoplasmic membrane, the periplasmic space, and the cell wall. ","synonyms":"Envelope.; ","content":"Cell envelope.","is_a":null,"part_of":null,"keyword":null,"gene_ontology":"GO:0030313; cell envelope; ","annotation":"Try to use a child/narrower/more specific term instead ","references":null,"links":"http://www.cf.ac.uk/biosi/staff/ehrmann/tools/ecce/ecce.htm; "},{"location_identifier":"Recycling endosome.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0232","definition":"The recycling endosome is a membrane network composed of narrow diameters tubules which concentrate in the vicinity of the microtubule organizing center. Recycling receptors after release of their ligands accumulate in those membranes which are devoid of fluid markers. Recycling endosomes may be an intermediate station for receptors before recycling back to the cell surface. ","synonyms":"Endosomal recycling compartment; ERC.; ","content":"Recycling endosome.","is_a":null,"part_of":"Endosome.; ","keyword":null,"gene_ontology":"GO:0055037; recycling endosome; ","annotation":"Compartment specific marker: Rab11. ","references":null,"links":null},{"location_identifier":"Endosome membrane.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0100","definition":"The membrane surrounding the endosome. Endosomes are highly dynamic membrane systems involved in transport within the cell, they receive endocytosed cell membrane molecules and sort them for either degradation or recycling back to the cell surface. ","synonyms":"Endosomal membrane.; ","content":"Endosome membrane.","is_a":"Membrane.; ","part_of":"Endosome.; Endomembrane system.; ","keyword":null,"gene_ontology":"GO:0010008; endosome membrane; ","annotation":null,"references":null,"links":null},{"location_identifier":"Endosome lumen.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0327","definition":"The endosomal compartment bounded by the endosomal membrane. ","synonyms":"Endosomal lumen.; ","content":"Endosome lumen.","is_a":null,"part_of":"Endosome.; ","keyword":null,"gene_ontology":"GO:0031904; endosome lumen; ","annotation":null,"references":null,"links":null},{"location_identifier":"Endomembrane system.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0147","definition":"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi apparatus, vesicles and cell membrane and nuclear envelope. The endomembrane system does not include the membranes of mitochondria or plastids. ","synonyms":"Endomembrane.; ","content":"Endomembrane system.","is_a":"Membrane.; ","part_of":null,"keyword":null,"gene_ontology":"GO:0012505; endomembrane system; ","annotation":"Try to use a child/narrower/more specific term instead ","references":null,"links":null},{"location_identifier":"Periplasmic flagellum.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0201","definition":"Spirochetes have a flagellum that resides inside the cell within the periplasmic space. The number of flagella varies from species to species. The rotation of these structures results in specific movements of the cell body, which in turn enable the locomotion of the cell. In particular they impart spirochetes the ability to propel themselves through viscous media that would inhibit the rotation of external flagellar filaments. ","synonyms":"Endoflagellum; Periplasmic fibril.; ","content":"Periplasmic flagellum.","is_a":"Bacterial flagellum.; ","part_of":null,"keyword":null,"gene_ontology":"GO:0055040; periplasmic flagellum; ","annotation":null,"references":"PubMed=15170401; DOI=10.1159/000077867;; ","links":null},{"location_identifier":"Zona pellucida.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0540","definition":"Zona pellucida is a specialized extracellular matrix that surrounds the plasma membrane of mammalian oocytes. It is required for successful fertilization. Zona pellucida allows species-specific fertilization, prevents polyspermy, and enables acrosomal reaction for the successful adhesion and penetration of the sperm cell. ","synonyms":"Egg coat; Pellucid zone; Vitelline membrane.; ","content":"Zona pellucida.","is_a":null,"part_of":"Extracellular matrix.; ","keyword":"KW-0272","gene_ontology":"GO:0035805; egg coat; ","annotation":null,"references":null,"links":null},{"location_identifier":"Early endosome membrane.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0093","definition":"The membrane surrounding the early endosomes, which form a tubulovesicular network spread throughout the cortical cytoplasm of the cell. ","synonyms":"Early endosomal membrane.; ","content":"Early endosome membrane.","is_a":"Endosome membrane.; ","part_of":"Early endosome.; ","keyword":null,"gene_ontology":"GO:0031901; early endosome membrane; ","annotation":null,"references":null,"links":null},{"location_identifier":"Early endosome lumen.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0337","definition":"The early endosomal compartment bounded by the membrane of early endosomes, which form a tubulovesicular network spread throughout the cortical cytoplasm of the cell. ","synonyms":"Early endosomal lumen.; ","content":"Early endosome lumen.","is_a":"Endosome lumen.; ","part_of":"Early endosome.; ","keyword":null,"gene_ontology":"GO:0031905; early endosome lumen; ","annotation":null,"references":null,"links":null},{"location_identifier":"Dynein axonemal particle.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0542","definition":"Dynein axonemal particles are ciliated cell-specific cytoplasmic membrane-less organelles, where dynein axonemal assembly factors (DNAAFs) and chaperones flux through rapidly while dynein subunits are stably retained. May act in storage or assembly of axonemal dyneins for rapid deployment to cilia. ","synonyms":"DynAP.; ","content":"Dynein axonemal particle.","is_a":null,"part_of":"Cytoplasm.; ","keyword":null,"gene_ontology":"GO:0120293; dynein axonemal particle; ","annotation":null,"references":"PubMed=33263282; DOI=10.7554/elife.38497;; ","links":null},{"location_identifier":"Desmosome.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0092","definition":"A desmosome (DS) is a button-like adhesion complex that stabilizes epithelial sheets by anchoring the intermediate filament cytoskeleton to the cell junction. Desmosomes are found particularly in tissues subjected to mechanical stress. ","synonyms":"DS; Macula adherens.; ","content":"Cell junction, desmosome.","is_a":"Cell junction.; ","part_of":null,"keyword":null,"gene_ontology":"GO:0030057; desmosome; ","annotation":"Add \"Cell membrane\" if the protein is clearly associated with the membrane. ","references":null,"links":"http://celljunctions.med.nyu.edu/desmosomes/desframe.html; "},{"location_identifier":"Golgi stack membrane.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0136","definition":"The membrane surrounding the Golgi stack. ","synonyms":"Dictyosome membrane; Golgi bodies membrane; Golgi body membrane;; Golgi cisterna membrane.; ","content":"Golgi apparatus, Golgi stack membrane.","is_a":"Golgi apparatus membrane.; ","part_of":"Golgi stack.; ","keyword":null,"gene_ontology":"GO:0032580; Golgi cisterna membrane; ","annotation":null,"references":null,"links":null},{"location_identifier":"Golgi stack lumen.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0334","definition":"The Golgi stack compartment bounded by the membrane of the Golgi stack. ","synonyms":"Dictyosome lumen; Golgi bodies lumen; Golgi body lumen.; ","content":"Golgi apparatus, Golgi stack lumen.","is_a":"Golgi apparatus lumen.; ","part_of":"Golgi stack.; ","keyword":null,"gene_ontology":"GO:0034469; Golgi stack lumen; ","annotation":null,"references":null,"links":null},{"location_identifier":"Golgi stack.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0135","definition":"The Golgi stack consist of a series of flattened curved and parallel series saccules, called cisternae or dictyosomes, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack. ","synonyms":"Dictyosome; Golgi bodies; Golgi body.; ","content":"Golgi apparatus, Golgi stack.","is_a":null,"part_of":"Golgi apparatus.; ","keyword":null,"gene_ontology":"GO:0005795; Golgi stack; ","annotation":"Compartment specific marker: Mannosidase II. ","references":null,"links":null},{"location_identifier":"Autolysosome lumen.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0537","definition":"The autolysosome lumen is the area enclosed by the autolysosomal membrane. ","synonyms":"Degrading autophagic vacuole lumen.; ","content":"Autolysosome lumen.","is_a":null,"part_of":"Autolysosome.; ","keyword":null,"gene_ontology":"GO:0120282; autolysosome lumen; ","annotation":null,"references":null,"links":null},{"location_identifier":"Autolysosome.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0535","definition":"The autolysosome is a single-membrane organelle resulting from the fusion of a double-membrane autophagosome with a lysosome during macroautophagy. The outer membrane of the autophagosome fuses with the lysosome membrane whereas the inner membrane and the autophagic cargo are released into the lumen and degraded. Alternatively, the convergence of macroautophagy and endocytosis produces a single- membrane amphisome that also results in an autolysosome upon fusion with a lysosome. ","synonyms":"Degrading autophagic vacuole.; ","content":"Autolysosome.","is_a":"Autophagosome.; Lysosome.; ","part_of":null,"keyword":null,"gene_ontology":"GO:0044754; autolysosome; ","annotation":null,"references":null,"links":null},{"location_identifier":"U-body.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0553","definition":"Non-membranous cytoplasmic structures containing Uridine-rich small nuclear ribonucleoproteins (U snRNPs) and snRNP assembly factors. U- bodies probably function as assembly or storage sites for snRNPs prior to their import into the nucleus. U-bodies associate with P-bodies and may cooperate in snRNP metabolism. ","synonyms":"Cytoplasmic U snRNP body; U bodies; U-bodies; U body.; ","content":"Cytoplasm, U-body.","is_a":"Cytoplasmic ribonucleoprotein granule.; ","part_of":null,"keyword":null,"gene_ontology":null,"annotation":null,"references":"PubMed=17183357; DOI=10.1073/pnas.0704977104;; ","links":null},{"location_identifier":"Cytoplasmic ribonucleoprotein granule.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0495","definition":"Cytoplasmic ribonucleoprotein granule is a collective term for distinct protein and RNA foci inside the cytoplasm, including processing bodies (P-bodies), U snRNP bodies (U-bodies), stress granules, neuronal ribonucleoprotein granule (neuronal transport granule) and germ granules (germline granules). ","synonyms":"Cytoplasmic mRNP granule; Cytoplasmic mRNP granules; mRNP granule;; mRNP granules.; ","content":"Cytoplasm, Cytoplasmic ribonucleoprotein granule.","is_a":null,"part_of":"Cytoplasm.; ","keyword":null,"gene_ontology":"GO:0036464; cytoplasmic ribonucleoprotein granule; ","annotation":"The synonym \"cytoplasmic body/bodies\" is also used to indicate cytoplasmic speckles or foci. In this case, the location \"Cytoplasmic ribonucleoprotein granule\" does not apply. ","references":"PubMed=25531407; DOI=10.4161/15476286.2014.972208;; ","links":null},{"location_identifier":"P-body.","topology_identifier":null,"orientation_identifier":null,"accession":"SL-0230","definition":"P-bodies are dynamic non-membrane bound cytoplasmic structures. These discrete foci function in mRNA decay (decapping and breakdown), RNA- mediated gene silencing (microRNA and siRNA-based gene silencing), mRNA surveillance (or quality control) and translational control. In addition to being sites of mRNA degradation, P-bodies can temporarily sequester mRNAs away from the translation machinery. P-bodies are present in unstressed cells, but are further induced in response to various stresses. ","synonyms":"Cytoplasmic mRNA processing body; DCP bodies; Dcp body; Gawky bodies;; Gawky body; GW182 bodies; GW182 body; GWB; GW bodies; GW body;; mRNA-decay foci; mRNA processing bodies; mRNA processing body; PB;; P bodies; P-bodies; P body; Processing bodies; Processing body.; ","content":"Cytoplasm, P-body.","is_a":"Cytoplasmic ribonucleoprotein granule.; ","part_of":null,"keyword":null,"gene_ontology":"GO:0000932; P-body; ","annotation":null,"references":"PubMed=17183357; DOI=10.1038/nrm2080;; ","links":null}]}