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{
"count": 543,
"next": "https://cinder.proteo.info/api/subcellular_locations/?format=api&limit=20&offset=120&ordering=-synonyms",
"previous": "https://cinder.proteo.info/api/subcellular_locations/?format=api&limit=20&offset=80&ordering=-synonyms",
"results": [
{
"location_identifier": "Clathrin-coated pit.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0069",
"definition": "Coated pits are regions of the cell membrane specialized in receptor- mediated endocytosis. Their cytoplasmic surface is coated with a bristlelike structure made of clathrin. During the first steps of endocytosis, clathrin-coated pits are internalized to form clathrin- coated vesicles which transport proteins from organelle to organelle. ",
"synonyms": null,
"content": "Membrane, clathrin-coated pit.",
"is_a": "Coated pit.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0005905; clathrin-coated pit; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "COPI-coated vesicle membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0076",
"definition": "The membrane surrounding a COPI-coated vesicle. COPI-coated vesicles mediate the vesicular transport of cargo such as proteins. COPI-coated vesicles are believed to bud from the cis-cisternae of the Golgi apparatus, mediate traffic from the cis-Golgi back to the ER (retrograde), and govern the flow pattern of materials within the Golgi stack. COPI is composed of the coatomer, which is a seven- subunit protein complex that participates in the formation of Golgi- derived coated vesicles. Evidence has also been presented for anterograde intra-Golgi transport mediated by COPI in yeast and mammals. ",
"synonyms": null,
"content": "Cytoplasmic vesicle, COPI-coated vesicle membrane.",
"is_a": "Cytoplasmic vesicle membrane.; ",
"part_of": "COPI-coated vesicle.; ",
"keyword": null,
"gene_ontology": "GO:0030663; COPI-coated vesicle membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Ascus epiplasm.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0538",
"definition": "Ascus cytoplasm that is not packaged into ascospores. ",
"synonyms": null,
"content": "Ascus epiplasm.",
"is_a": null,
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0072324; ascus epiplasm; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Cyanelle envelope.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0479",
"definition": "The envelope of a cyanelle comprises the inner and outer cyanelle membrane including the intermembrane space and the vestigal peptidoglycan layer. ",
"synonyms": null,
"content": "Plastid, cyanelle envelope.",
"is_a": "Plastid envelope.; ",
"part_of": "Cyanelle.; ",
"keyword": null,
"gene_ontology": "GO:0033112; cyanelle envelope; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Host endoplasmic reticulum membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0390",
"definition": "The membrane surrounding the host endoplasmic reticulum (ER). The host endoplasmic reticulum is an extensive network of membrane tubules, vesicles and flattened cisternae (sac-like structures) found throughout the eukaryotic host cell, especially those responsible for the production of hormones and other secretory products. ",
"synonyms": null,
"content": "Host endoplasmic reticulum membrane.",
"is_a": "Host membrane.; ",
"part_of": "Host endoplasmic reticulum.; Host endomembrane system.; ",
"keyword": null,
"gene_ontology": "GO:0044167; host cell endoplasmic reticulum membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Cleavage furrow.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0467",
"definition": "In fungal, amoeboid and animal cells, during the cytokinesis at the end of cell division, a cleavage furrow forms in the plasma membrane. A contractile ring containing actin and myosin is assembled at the selected site of the future cleavage furrow. Ring contraction produces the force to constrict the cleavage furrow and the daughter cells separate by membrane fusion. ",
"synonyms": null,
"content": "Cleavage furrow.",
"is_a": null,
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0032154; cleavage furrow; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Coated pit.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0072",
"definition": "Coated pits are regions of the donor membrane where the assembly of the vesicle coat take place. The coat assembles from soluble protomers such as coat protein complex-I and coat protein complex-II. The components of the coat often define the intracellular sorting station, and contribute to both membrane deformation and local movement of the resulting transport intermediate following scission. During the first steps of the vesicle-mediated membrane transport, coated pits are internalized to form coated vesicles which transport proteins between distinct membrane-bound organelles. ",
"synonyms": null,
"content": "Membrane, coated pit.",
"is_a": null,
"part_of": "Endomembrane system.; ",
"keyword": "KW-0168",
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Chloroplast thylakoid lumen.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0057",
"definition": "The chloroplast thylakoid lumen is the chloroplast compartment bounded by the thylakoid membranes. ",
"synonyms": null,
"content": "Plastid, chloroplast thylakoid lumen.",
"is_a": "Plastid thylakoid lumen.; ",
"part_of": "Chloroplast thylakoid.; ",
"keyword": null,
"gene_ontology": "GO:0009543; chloroplast thylakoid lumen; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Cytolytic granule membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0547",
"definition": "The cytolytic granule membrane is the membrane surrounding a cytolytic granule. ",
"synonyms": null,
"content": "Cytolytic granule membrane.",
"is_a": "Lysosome membrane.; ",
"part_of": "Cytolytic granule.; ",
"keyword": null,
"gene_ontology": "GO:0101004; cytolytic granule membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Extracellular vesicle membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0500",
"definition": "The membrane surrounding an extracellular vesicle. ",
"synonyms": null,
"content": "Extracellular vesicle membrane.",
"is_a": "Membrane.; ",
"part_of": "Extracellular vesicle.; ",
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Capsule.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0033",
"definition": "The capsule is a protective structure surrounding some bacteria or fungi. The bacterial capsule is a layer of material, usually polysaccharide, attached to the cell wall possibly via covalent attachments to either phospholipid or lipid-A molecules. It has several functions: promote bacterial adhesion to surfaces or interaction with other organisms; act as a permeability barrier, as a defense mechanism against phagocytosis and/or as a nutrient reserve. Among pathogens, capsule formation often correlates with pathogenicity. The fungal capsule is an extracellular layer which lies outside the cell wall and it is usually composed of polysaccharides. It protects the cell from different environmental dangers such as phagocytosis, dessication, etc. ",
"synonyms": null,
"content": "Secreted, capsule.",
"is_a": null,
"part_of": "Cell envelope.; Secreted.; ",
"keyword": null,
"gene_ontology": "GO:0042603; capsule; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "COPI-coated vesicle lumen.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0321",
"definition": "The COPI-coated vesicle compartment bounded by the COPI-coated vesicle membrane. ",
"synonyms": null,
"content": "Cytoplasmic vesicle, COPI-coated vesicle lumen.",
"is_a": "Cytoplasmic vesicle lumen.; ",
"part_of": "COPI-coated vesicle.; ",
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Cytolytic granule lumen.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0546",
"definition": "The cytolytic granule comparment bounded by the cytolytic granule membrane. ",
"synonyms": null,
"content": "Cytolytic granule lumen.",
"is_a": "Lysosome lumen.; ",
"part_of": "Cytolytic granule.; ",
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Carboxysome.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0034",
"definition": "Carboxysomes are bacterial microcompartments in which ribulose bisphosphate carboxylase (RuBisCO)-mediated CO(2) fixation occurs. The cytoplasmic polyhedral inclusion bodies are surrounded by a thin protein coat. They enhance autotrophic CO(2) fixation in air by increasing the CO(2) concentration around RuBisCO, thus reducing its reaction with O(2), a competing substrate. They contain carbonic anhydrase as part of the CO(2) concentration mechanism. ",
"synonyms": null,
"content": "Carboxysome.",
"is_a": "Bacterial microcompartment.; ",
"part_of": null,
"keyword": "KW-1282",
"gene_ontology": "GO:0031470; carboxysome; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Host cytoplasmic vesicle.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0386",
"definition": "The host cytoplasmic vesicles mediate vesicular transport among the organelles of host secretory and endocytic systems. ",
"synonyms": null,
"content": "Host cytoplasmic vesicle.",
"is_a": null,
"part_of": "Host cell.; ",
"keyword": "KW-1036",
"gene_ontology": "GO:0044161; host cell cytoplasmic vesicle; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Dendritic spine membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0285",
"definition": "The portion of the cell membrane surrounding the dendritic spine, a small, club-like cell protrusion from neuronal dendrites that form the postsynaptic component of most excitatory synapses in the brain. ",
"synonyms": null,
"content": "Cell projection, dendritic spine membrane.",
"is_a": "Postsynaptic cell membrane.; ",
"part_of": "Dendritic spine.; ",
"keyword": null,
"gene_ontology": "GO:0032591; dendritic spine membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Cornified envelope.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0079",
"definition": "The cornified envelope is a structure which is formed beneath the plasma membrane in terminally differentiating stratified squamous epithelia. It provides a vital physical barrier to these tissues in mammals and consists of a 10 nm thick layer of highly crosslinked insoluble proteins. In the specialized case of the epidermis, a 5 nm thick layer of ceramide lipids is covalently bound to the proteins. These organize extracellular lipids into orderly lamellae and, together, the cell envelope and extracellular lipids are essential for effective physical and water barrier function in the skin. ",
"synonyms": null,
"content": "Cornified envelope.",
"is_a": null,
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0001533; cornified envelope; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Cell cortex.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0138",
"definition": "The cell cortex is the cytoplasmic region under the cell membrane. ",
"synonyms": null,
"content": "Cytoplasm, cell cortex.",
"is_a": null,
"part_of": "Cytoplasm.; ",
"keyword": null,
"gene_ontology": "GO:0005938; cell cortex; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Cvt vesicle.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0080",
"definition": "A cvt vesicle is a double membrane-layered vesicle implicated in the cytoplasm to vacuole targeting pathway. ",
"synonyms": null,
"content": "Cytoplasmic vesicle, cvt vesicle.",
"is_a": "Cytoplasmic vesicle.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0033107; Cvt vesicle; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Kinetoplast.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0150",
"definition": "The mitochondrial DNA of trypanosomatid protozoa is termed kinetoplast DNA (kDNA). kDNA is a massive network, composed of thousands of topologically interlocked DNA circles. Each cell contains one network condensed into a disk-shaped structure within the matrix of its single mitochondrion. The kDNA circles are of two types, maxicircles present in a few dozen copies and minicircles present in several thousand copies. ",
"synonyms": null,
"content": "Mitochondrion matrix, kinetoplast.",
"is_a": null,
"part_of": "Mitochondrion matrix.; ",
"keyword": "KW-0419",
"gene_ontology": "GO:0020023; kinetoplast; ",
"annotation": null,
"references": null,
"links": null
}
]
}