HTTP 200 OK
Allow: GET, POST, HEAD, OPTIONS
Content-Type: application/json
Vary: Accept
{
"count": 543,
"next": "https://cinder.proteo.info/api/subcellular_locations/?format=api&limit=20&offset=160",
"previous": "https://cinder.proteo.info/api/subcellular_locations/?format=api&limit=20&offset=120",
"results": [
{
"location_identifier": "Invadopodium.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0148",
"definition": "The invadopodium is a localized and persitent cell protrusion similar to the highly dynamic podosome, but larger. These structures protrudes into the extracellular matrix. Invadopodial protrusions are enriched in integrins, tyrosine kinase signaling machinery, soluble and membrane proteases including matrix metalloproteases, actin and actin- associated proteins. Essential for physiological and pathological cell invasion and metastasis these structures are involved in focalized degradation of the extracellular matrix. Invadopodia form underneath the cell body, often close to the nucleus and proximal to the Golgi complex, and are rarely found at the cell periphery. Their half-life is quite extended. As invadopodia and podosomes are similar in appearance, location and composition, it is likely that a thin line separates these two entities in time and function. ",
"synonyms": "Invadopodia.; ",
"content": "Cell projection, invadopodium.",
"is_a": "Cell junction.; Cell projection.; ",
"part_of": null,
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": "PubMed=16546558; DOI=10.1016/j.ejcb.2005.09.005;; ",
"links": null
},
{
"location_identifier": "Kinetochore.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0149",
"definition": "The kinetochore is a protein complex assembled on the centromeric region of DNA. It provides the major attachment point for the spindle microtubules during mitotic or meiotic division to pull the chromosomes apart. In monocentric chromosomes, the kinetochores of point centromeres bind a single microtubule and the larger kinetochores of regional centromeres interact with a number of microtubules. In holocentric chromosomes, the kinetochores bind the diffuse centromere along the length of the chromosomes. ",
"synonyms": null,
"content": "Chromosome, centromere, kinetochore.",
"is_a": null,
"part_of": "Centromere.; ",
"keyword": "KW-0995",
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Kinetoplast.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0150",
"definition": "The mitochondrial DNA of trypanosomatid protozoa is termed kinetoplast DNA (kDNA). kDNA is a massive network, composed of thousands of topologically interlocked DNA circles. Each cell contains one network condensed into a disk-shaped structure within the matrix of its single mitochondrion. The kDNA circles are of two types, maxicircles present in a few dozen copies and minicircles present in several thousand copies. ",
"synonyms": null,
"content": "Mitochondrion matrix, kinetoplast.",
"is_a": null,
"part_of": "Mitochondrion matrix.; ",
"keyword": "KW-0419",
"gene_ontology": "GO:0020023; kinetoplast; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Late endosome membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0151",
"definition": "The membrane surrounding the late endosomes. ",
"synonyms": "Late endosomal membrane.; ",
"content": "Late endosome membrane.",
"is_a": "Endosome membrane.; ",
"part_of": "Late endosome.; ",
"keyword": null,
"gene_ontology": "GO:0031902; late endosome membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Late endosome.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0152",
"definition": "Late endosomes are pleiomorphic with cisternal, tubular and multivesicular regions. They are found in juxtanuclear regions and concentrated at the microtubule organizing center. They are an important sorting station in the endocytic pathway. Recycling to the plasma membrane and to the Golgi occurs in late endosomes. More acidic than early endosomes they are also loaded more slowly in a range of 4 to 30 minutes depending on the cell type. They can be distinguished from lysosome for their enrichment in M6PR. ",
"synonyms": null,
"content": "Late endosome.",
"is_a": null,
"part_of": "Endosome.; ",
"keyword": null,
"gene_ontology": "GO:0005770; late endosome; ",
"annotation": "Compartment specific marker: Rab7; Rab9; LBPA. ",
"references": null,
"links": null
},
{
"location_identifier": "Lateral cell membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0153",
"definition": "The portion of the plasma membrane at the lateral side of the cell. ",
"synonyms": "Lateral plasma membrane.; ",
"content": "Lateral cell membrane.",
"is_a": null,
"part_of": "Cell membrane.; ",
"keyword": null,
"gene_ontology": "GO:0016328; lateral plasma membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Lipid droplet.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0154",
"definition": "The lipid droplet is a dynamic cytoplasmic organelle which consists of an heterogeneous macromolecular assembly of lipids and proteins covered by a unique phospholipid monolayer. Lipid droplets may play a role in lipid metabolism and storage, and they may be involved in the regulation of intracellular trafficking and signal transduction. ",
"synonyms": "Adiposome; Lipid bodies; Lipid body; Lipid particle;; Monolayer-surrounded lipid storage body; Oil bodies; Oil body;; Oleosome; Spherosome.; ",
"content": "Lipid droplet.",
"is_a": null,
"part_of": null,
"keyword": "KW-0551",
"gene_ontology": "GO:0005811; lipid droplet; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Lysosome lumen.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0156",
"definition": "The lumen of a lysosome is the volume enclosed within the lysosomal membrane. ",
"synonyms": "Lysosomal lumen.; ",
"content": "Lysosome lumen.",
"is_a": null,
"part_of": "Lysosome.; ",
"keyword": null,
"gene_ontology": "GO:0043202; lysosomal lumen; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Lysosome membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0157",
"definition": "The membrane surrounding a lysosome. ",
"synonyms": "Lysosomal membrane.; ",
"content": "Lysosome membrane.",
"is_a": "Membrane.; ",
"part_of": "Endomembrane system.; Lysosome.; ",
"keyword": null,
"gene_ontology": "GO:0005765; lysosomal membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Lysosome.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0158",
"definition": "The lysosome is a membrane-limited organelle present in all eukaryotic cells, which contains a large number of hydrolytic enzymes that are used for degrading almost any kind of cellular constituent, including entire organelles. The mechanisms responsible for delivering cytoplasmic cargo to the lysosome/vacuole are known collectively as autophagy and play an important role in the maintenance of homeostasis. ",
"synonyms": null,
"content": "Lysosome.",
"is_a": null,
"part_of": null,
"keyword": "KW-0458",
"gene_ontology": "GO:0005764; lysosome; ",
"annotation": "Compartment specific marker: LAMP-1; LAMP-2?. ",
"references": null,
"links": null
},
{
"location_identifier": "Lytic vacuole.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0159",
"definition": "The lytic vacuole is a plant specialized vacuole equivalent to animal lysosomes or yeast vacuoles, functioning as compartments for degradation and waste storage. ",
"synonyms": null,
"content": "Lytic vacuole.",
"is_a": "Vacuole.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0000323; lytic vacuole; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Melanosome membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0160",
"definition": "The membrane surrounding a melanosome. ",
"synonyms": "Melanosomal membrane.; ",
"content": "Melanosome membrane.",
"is_a": "Membrane.; ",
"part_of": "Endomembrane system.; Melanosome.; ",
"keyword": null,
"gene_ontology": "GO:0033162; melanosome membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Melanosome.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0161",
"definition": "The melanosome is a melanin-containing organelle found in melanocytes and melanophores. Fish and amphibians possess specialized cells, called melanophores, which contain hundreds of melanin-filled pigment granules, termed melanosomes. The sole function of these cells is pigment aggregation in the center of the cell or dispersion throughout the cytoplasm. This alternative transport of pigment allows the animal to effect color changes important for camouflage and social interactions. Melanophores transport their pigment in response to extracellular cues: neurotransmitters in the case of fish and hormonal stimuli in the case of frogs. In both cases, melanosome dispersion is induced by elevation of intracellular cAMP levels, while aggregation is triggered by depression of cAMP. The regulatory mechanisms downstream of these second-messengers are poorly understood. Mammalian melanocytes also produce melanosomes but, unlike melanophores, pigment in these cells is transported to the cell periphery for subsequent exocytosis to surrounding epithelial cells. ",
"synonyms": null,
"content": "Melanosome.",
"is_a": null,
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0042470; melanosome; ",
"annotation": null,
"references": null,
"links": "http://www.proweb.org/kinesin/Melanophore.html; "
},
{
"location_identifier": "Membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0162",
"definition": "A membrane is a lipid bilayer which surrounds enclosed spaces and compartments. This selectively permeable structure is essential for effective separation of a cell or organelle from its surroundings. Membranes are composed of various types of molecules such as phospholipids, integral membrane proteins, peripheral proteins, glycoproteins, glycolipids, etc. The relative amounts of these components as well as the types of lipids are non-randomly distributed from membrane to membrane as well as between the two leaflets of a membrane. ",
"synonyms": null,
"content": "Membrane.",
"is_a": null,
"part_of": null,
"keyword": "KW-0472",
"gene_ontology": "GO:0016020; membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Microneme.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0163",
"definition": "The microneme is an Apicomplexan parasite organelle. Apicomplexa are named for the unique set of morphologically distinct secretory organelles (refered to as the apical complex)- micronemes, rhoptries and dense granules - whose sequential secretion is required for the invasion of host cells. Micronemes are the smallest, they are involved in the early stages of invasion. ",
"synonyms": null,
"content": "Cytoplasmic vesicle, secretory vesicle, microneme.",
"is_a": "Secretory vesicle.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0020009; microneme; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Microneme membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0164",
"definition": "The membrane surrounding a microneme. ",
"synonyms": "Micronemal membrane.; ",
"content": "Cytoplasmic vesicle, secretory vesicle, microneme membrane.",
"is_a": "Secretory vesicle membrane.; ",
"part_of": "Microneme.; ",
"keyword": null,
"gene_ontology": "GO:0033163; microneme membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Microsome membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0165",
"definition": "The membrane surrounding the microsome. ",
"synonyms": "Microsomal membrane.; ",
"content": "Microsome membrane.",
"is_a": "Membrane.; ",
"part_of": "Endomembrane system.; Microsome.; ",
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Microsome.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0166",
"definition": "The microsomes are a heterogenous set of vesicles 20-200nm in diameter and formed from the endoplasmic reticulum when cells are disrupted. The vesicles are isolated by differential centrifugation and are composed of three structural features: rough vesicles, smooth vesicles and ribosomes. Numerous enzyme activities are associated with the microsomal fraction. ",
"synonyms": null,
"content": "Microsome.",
"is_a": null,
"part_of": "Endoplasmic reticulum.; ",
"keyword": "KW-0492",
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Mitochondrion envelope.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0167",
"definition": "The mitochondrial envelope comprises the inner and outer mitochondrial membrane including the intermembrane space. ",
"synonyms": "Mitochondrial envelope.; ",
"content": "Mitochondrion envelope.",
"is_a": null,
"part_of": "Mitochondrion.; ",
"keyword": null,
"gene_ontology": "GO:0005740; mitochondrial envelope; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Mitochondrion inner membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0168",
"definition": "The inner membrane of a mitochondrion is the membrane which separates the mitochondrial matrix from the intermembrane space. ",
"synonyms": "Inner mitochondrial membrane; Mitochondrial inner membrane.; ",
"content": "Mitochondrion inner membrane.",
"is_a": "Mitochondrion membrane.; ",
"part_of": null,
"keyword": "KW-0999",
"gene_ontology": "GO:0005743; mitochondrial inner membrane; ",
"annotation": null,
"references": null,
"links": null
}
]
}