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{
"count": 543,
"next": "https://cinder.proteo.info/api/subcellular_locations/?format=api&limit=20&offset=240&ordering=-location_identifier",
"previous": "https://cinder.proteo.info/api/subcellular_locations/?format=api&limit=20&offset=200&ordering=-location_identifier",
"results": [
{
"location_identifier": "Melanosome membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0160",
"definition": "The membrane surrounding a melanosome. ",
"synonyms": "Melanosomal membrane.; ",
"content": "Melanosome membrane.",
"is_a": "Membrane.; ",
"part_of": "Endomembrane system.; Melanosome.; ",
"keyword": null,
"gene_ontology": "GO:0033162; melanosome membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Melanosome lumen.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0338",
"definition": "The melanosomal compartment bounded by the membrane surrounding a melanosome. ",
"synonyms": "Melanosomal lumen.; ",
"content": "Melanosome lumen.",
"is_a": null,
"part_of": "Melanosome.; ",
"keyword": null,
"gene_ontology": "GO:0034493; melanosome lumen; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Melanosome.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0161",
"definition": "The melanosome is a melanin-containing organelle found in melanocytes and melanophores. Fish and amphibians possess specialized cells, called melanophores, which contain hundreds of melanin-filled pigment granules, termed melanosomes. The sole function of these cells is pigment aggregation in the center of the cell or dispersion throughout the cytoplasm. This alternative transport of pigment allows the animal to effect color changes important for camouflage and social interactions. Melanophores transport their pigment in response to extracellular cues: neurotransmitters in the case of fish and hormonal stimuli in the case of frogs. In both cases, melanosome dispersion is induced by elevation of intracellular cAMP levels, while aggregation is triggered by depression of cAMP. The regulatory mechanisms downstream of these second-messengers are poorly understood. Mammalian melanocytes also produce melanosomes but, unlike melanophores, pigment in these cells is transported to the cell periphery for subsequent exocytosis to surrounding epithelial cells. ",
"synonyms": null,
"content": "Melanosome.",
"is_a": null,
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0042470; melanosome; ",
"annotation": null,
"references": null,
"links": "http://www.proweb.org/kinesin/Melanophore.html; "
},
{
"location_identifier": "Magnetosome membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0512",
"definition": "The magnetosome membrane. ",
"synonyms": null,
"content": "Magnetosome membrane.",
"is_a": "Membrane.; ",
"part_of": "Magnetosome.; ",
"keyword": null,
"gene_ontology": "GO:0110146; magnetosome membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Magnetosome lumen.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0511",
"definition": "The magnetosome lumen. ",
"synonyms": null,
"content": "Magnetosome, Magnetosome lumen.",
"is_a": null,
"part_of": "Magnetosome.; ",
"keyword": null,
"gene_ontology": "GO:0110145; magnetosome lumen; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Magnetosome.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0510",
"definition": "A specialized, membrane-bound bacterial organelle that envelops nanometer-sized crystals of magnetic iron minerals. They form linear chains at midcell along the cellular motility axis. ",
"synonyms": null,
"content": "Magnetosome.",
"is_a": null,
"part_of": null,
"keyword": "KW-1281",
"gene_ontology": "GO:0110143; magnetosome; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Lytic vacuole.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0159",
"definition": "The lytic vacuole is a plant specialized vacuole equivalent to animal lysosomes or yeast vacuoles, functioning as compartments for degradation and waste storage. ",
"synonyms": null,
"content": "Lytic vacuole.",
"is_a": "Vacuole.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0000323; lytic vacuole; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Lysosome membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0157",
"definition": "The membrane surrounding a lysosome. ",
"synonyms": "Lysosomal membrane.; ",
"content": "Lysosome membrane.",
"is_a": "Membrane.; ",
"part_of": "Endomembrane system.; Lysosome.; ",
"keyword": null,
"gene_ontology": "GO:0005765; lysosomal membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Lysosome lumen.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0156",
"definition": "The lumen of a lysosome is the volume enclosed within the lysosomal membrane. ",
"synonyms": "Lysosomal lumen.; ",
"content": "Lysosome lumen.",
"is_a": null,
"part_of": "Lysosome.; ",
"keyword": null,
"gene_ontology": "GO:0043202; lysosomal lumen; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Lysosome.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0158",
"definition": "The lysosome is a membrane-limited organelle present in all eukaryotic cells, which contains a large number of hydrolytic enzymes that are used for degrading almost any kind of cellular constituent, including entire organelles. The mechanisms responsible for delivering cytoplasmic cargo to the lysosome/vacuole are known collectively as autophagy and play an important role in the maintenance of homeostasis. ",
"synonyms": null,
"content": "Lysosome.",
"is_a": null,
"part_of": null,
"keyword": "KW-0458",
"gene_ontology": "GO:0005764; lysosome; ",
"annotation": "Compartment specific marker: LAMP-1; LAMP-2?. ",
"references": null,
"links": null
},
{
"location_identifier": "Lipid droplet.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0154",
"definition": "The lipid droplet is a dynamic cytoplasmic organelle which consists of an heterogeneous macromolecular assembly of lipids and proteins covered by a unique phospholipid monolayer. Lipid droplets may play a role in lipid metabolism and storage, and they may be involved in the regulation of intracellular trafficking and signal transduction. ",
"synonyms": "Adiposome; Lipid bodies; Lipid body; Lipid particle;; Monolayer-surrounded lipid storage body; Oil bodies; Oil body;; Oleosome; Spherosome.; ",
"content": "Lipid droplet.",
"is_a": null,
"part_of": null,
"keyword": "KW-0551",
"gene_ontology": "GO:0005811; lipid droplet; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Lateral cell membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0153",
"definition": "The portion of the plasma membrane at the lateral side of the cell. ",
"synonyms": "Lateral plasma membrane.; ",
"content": "Lateral cell membrane.",
"is_a": null,
"part_of": "Cell membrane.; ",
"keyword": null,
"gene_ontology": "GO:0016328; lateral plasma membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Late endosome membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0151",
"definition": "The membrane surrounding the late endosomes. ",
"synonyms": "Late endosomal membrane.; ",
"content": "Late endosome membrane.",
"is_a": "Endosome membrane.; ",
"part_of": "Late endosome.; ",
"keyword": null,
"gene_ontology": "GO:0031902; late endosome membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Late endosome lumen.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0336",
"definition": "The late endosomal comaprtment bounded by the membrane of the late endosome. ",
"synonyms": "Late endosomal lumen.; ",
"content": "Late endosome lumen.",
"is_a": "Endosome lumen.; ",
"part_of": "Late endosome.; ",
"keyword": null,
"gene_ontology": "GO:0031906; late endosome lumen; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Late endosome.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0152",
"definition": "Late endosomes are pleiomorphic with cisternal, tubular and multivesicular regions. They are found in juxtanuclear regions and concentrated at the microtubule organizing center. They are an important sorting station in the endocytic pathway. Recycling to the plasma membrane and to the Golgi occurs in late endosomes. More acidic than early endosomes they are also loaded more slowly in a range of 4 to 30 minutes depending on the cell type. They can be distinguished from lysosome for their enrichment in M6PR. ",
"synonyms": null,
"content": "Late endosome.",
"is_a": null,
"part_of": "Endosome.; ",
"keyword": null,
"gene_ontology": "GO:0005770; late endosome; ",
"annotation": "Compartment specific marker: Rab7; Rab9; LBPA. ",
"references": null,
"links": null
},
{
"location_identifier": "Lamellipodium membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0292",
"definition": "The portion of the cell membrane surrounding a lamellipodium. ",
"synonyms": null,
"content": "Cell projection, lamellipodium membrane.",
"is_a": null,
"part_of": "Cell membrane.; Lamellipodium.; ",
"keyword": null,
"gene_ontology": "GO:0031258; lamellipodium membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Lamellipodium.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0291",
"definition": "The lamellipodium is a broad, flat, veil-shaped cell protrusion formed at the leading edge of migrating cells. Lamellipodium contain a branched dendritic network of actin filaments having their barbed ends directed towards the cell membrane. It is associated with ameboid motility (or crawling motility). ",
"synonyms": "Lamellipodia; Veil.; ",
"content": "Cell projection, lamellipodium.",
"is_a": "Cell projection.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0030027; lamellipodium; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Kinocilium.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0460",
"definition": "The kinocilium is an immotile primary cilium that is found at the apical surface of auditory receptor cells. Hair bundles, the mechanosensory device of the sensory hair cells, are composed of height-ranked rows of stereocilia and a single kinocilium that are interconnected by extracellular proteinaceous links. ",
"synonyms": "Kinocilia.; ",
"content": "Cell projection, kinocilium.",
"is_a": "Cilium.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0060091; kinocilium; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Kinetoplast.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0150",
"definition": "The mitochondrial DNA of trypanosomatid protozoa is termed kinetoplast DNA (kDNA). kDNA is a massive network, composed of thousands of topologically interlocked DNA circles. Each cell contains one network condensed into a disk-shaped structure within the matrix of its single mitochondrion. The kDNA circles are of two types, maxicircles present in a few dozen copies and minicircles present in several thousand copies. ",
"synonyms": null,
"content": "Mitochondrion matrix, kinetoplast.",
"is_a": null,
"part_of": "Mitochondrion matrix.; ",
"keyword": "KW-0419",
"gene_ontology": "GO:0020023; kinetoplast; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Kinetochore.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0149",
"definition": "The kinetochore is a protein complex assembled on the centromeric region of DNA. It provides the major attachment point for the spindle microtubules during mitotic or meiotic division to pull the chromosomes apart. In monocentric chromosomes, the kinetochores of point centromeres bind a single microtubule and the larger kinetochores of regional centromeres interact with a number of microtubules. In holocentric chromosomes, the kinetochores bind the diffuse centromere along the length of the chromosomes. ",
"synonyms": null,
"content": "Chromosome, centromere, kinetochore.",
"is_a": null,
"part_of": "Centromere.; ",
"keyword": "KW-0995",
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
}
]
}