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{
"count": 543,
"next": "https://cinder.proteo.info/api/subcellular_locations/?format=api&limit=20&offset=260&ordering=-location_identifier",
"previous": "https://cinder.proteo.info/api/subcellular_locations/?format=api&limit=20&offset=220&ordering=-location_identifier",
"results": [
{
"location_identifier": "Invadopodium membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0290",
"definition": "The portion of the cell membrane surrounding an invadopodium. ",
"synonyms": null,
"content": "Cell projection, invadopodium membrane.",
"is_a": null,
"part_of": "Cell membrane.; Invadopodium.; ",
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Invadopodium.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0148",
"definition": "The invadopodium is a localized and persitent cell protrusion similar to the highly dynamic podosome, but larger. These structures protrudes into the extracellular matrix. Invadopodial protrusions are enriched in integrins, tyrosine kinase signaling machinery, soluble and membrane proteases including matrix metalloproteases, actin and actin- associated proteins. Essential for physiological and pathological cell invasion and metastasis these structures are involved in focalized degradation of the extracellular matrix. Invadopodia form underneath the cell body, often close to the nucleus and proximal to the Golgi complex, and are rarely found at the cell periphery. Their half-life is quite extended. As invadopodia and podosomes are similar in appearance, location and composition, it is likely that a thin line separates these two entities in time and function. ",
"synonyms": "Invadopodia.; ",
"content": "Cell projection, invadopodium.",
"is_a": "Cell junction.; Cell projection.; ",
"part_of": null,
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": "PubMed=16546558; DOI=10.1016/j.ejcb.2005.09.005;; ",
"links": null
},
{
"location_identifier": "Interphotoreceptor matrix.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0146",
"definition": "In vertebrates, the photoreceptors are separated from the retinal pigment epithelium by the subretinal space, which contains a specialized extracellular material referred to as interphotoreceptor matrix. The IPM mediates key interactions between the photoreceptors and RPE including adhesion, phagocytosis, outer segment stability, nutrient exchange, development, and vitamin A trafficking in the visual cycle. ",
"synonyms": "IPM.; ",
"content": "Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix.",
"is_a": "Extracellular matrix.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0033165; interphotoreceptor matrix; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Inner membrane complex.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0362",
"definition": "The inner membrane complex, found in apicocomplexan parasites, is composed of flattened membrane cisternae closely associated to the cell membrane. Together, the cell membrane and the IMC form a triple lipid bilayer called the pellicle (or cell wall). ",
"synonyms": "IMC.; ",
"content": "Inner membrane complex.",
"is_a": null,
"part_of": "Membrane.; ",
"keyword": null,
"gene_ontology": "GO:0070258; inner membrane pellicle complex; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Inflammasome.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0488",
"definition": "Inflammasomes are supramolecular micron-sized complexes that assemble in the cytosol adjacent to the nucleus in response to pathogens and other damage-associated signals. The inflammasome assembly leads to the activation of proinflammatory procaspases, hence is usually involved in innate immunity and inflammation. The core of inflammasomes consists of at least 2 components: a signal sensor and an effector inflammatory caspase (mostly CASP1). However, most inflammasomes contain a third element, an adaptor (often ASC/PYCARD). The interaction between the sensor component and the adaptor initiates speck formation (nucleation) which greatly enhances further addition of soluble adaptor molecules to the speck in a prion-like polymerization process. The kinetic properties of the adaptor aggregation have been shown to generate a rapid 'all-or-none' response, this is why only one speck by cell is observed. ",
"synonyms": "ASC focus; ASC speck.; ",
"content": "Inflammasome.",
"is_a": null,
"part_of": "Cytosol.; ",
"keyword": "KW-1271",
"gene_ontology": "GO:0061702; canonical inflammasome complex; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "I band.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0478",
"definition": "The appearance of the striated muscle is created by a pattern of alternating dark A bands and light I bands. I bands are composed of thin actin filaments and proteins that bind actin and they are bisected by the Z line. The thin filaments extend in each direction from the Z-disk, where they do not overlap the thick filaments, they create the light I band. ",
"synonyms": "I-band; I disc; I disk.; ",
"content": "Cytoplasm, myofibril, sarcomere, I band.",
"is_a": null,
"part_of": "Sarcomere.; ",
"keyword": null,
"gene_ontology": "GO:0031674; I band; ",
"annotation": null,
"references": null,
"links": "http://www.sarcomere.org/; "
},
{
"location_identifier": "H zone.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0477",
"definition": "The A band of a sarcomer is bisected by a paler zone, the H zone, where the thick and the thin filaments do not overlap. At the center of the H zone is the M line. ",
"synonyms": "H band; H-band; H disc; H disk.; ",
"content": "Cytoplasm, myofibril, sarcomere, H zone.",
"is_a": null,
"part_of": "A band.; ",
"keyword": null,
"gene_ontology": "GO:0031673; H zone; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Hydrogenosome membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0144",
"definition": "The membrane surrounding the hydrogenosome, a redox organelle found in anaerobic unicellular eukaryotes. ",
"synonyms": "Hydrogenosomal membrane.; ",
"content": "Hydrogenosome membrane.",
"is_a": "Membrane.; ",
"part_of": "Hydrogenosome.; ",
"keyword": null,
"gene_ontology": "GO:0046859; hydrogenosomal membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Hydrogenosome lumen.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0335",
"definition": "The hydrogenosomal compartment bounded by the membrane of the hydrogenosome, a redox organelle found in anaerobic unicellular eukaryotes. ",
"synonyms": "Hydrogenosomal lumen.; ",
"content": "Hydrogenosome lumen.",
"is_a": null,
"part_of": "Hydrogenosome.; ",
"keyword": null,
"gene_ontology": "GO:0034492; hydrogenosome lumen; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Hydrogenosome.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0145",
"definition": "The hydrogenosome is a redox organelle of anaerobic unicellular eukaryotes which contains hydrogenase and produces hydrogen and ATP by glycolysis. They are found in various unrelated eukaryotes, such as anaerobic flagellates, chytridiomycete fungi and ciliates. Most hydrogenosomes lack a genome, but some like that of the anaerobic ciliate Nyctotherus ovalis, have retained a rudimentary genome. ",
"synonyms": null,
"content": "Hydrogenosome.",
"is_a": null,
"part_of": null,
"keyword": "KW-0377",
"gene_ontology": "GO:0042566; hydrogenosome; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Hyaline layer.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0143",
"definition": "The hyaline layer is a multilayered extracellular matrix that coats the external surfaces of sea urchin and starfish embryos. ",
"synonyms": null,
"content": "Secreted, extracellular space, extracellular matrix, hyaline layer.",
"is_a": "Extracellular matrix.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0033166; hyaline layer; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Host vacuole.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0506",
"definition": "The host vacuole is a fluid-filled, membrane-bound compartment in the cytoplasm. The precise form and function of vacuoles may vary between phyla. They are employed for a variety of purposes, including storage, as a degradative compartment, cell size control, secretion and following phagocytosis. ",
"synonyms": null,
"content": "Host vacuole.",
"is_a": null,
"part_of": "Host cell.; ",
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Host trans-Golgi network membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0464",
"definition": "The membrane surrounding the host trans-Golgi network. ",
"synonyms": "Host Golgi trans-face membrane; Host TGN membrane;; Host trans-Golgi complex membrane; Host trans-Golgi membrane.; ",
"content": "Host Golgi apparatus, host trans-Golgi network membrane.",
"is_a": "Host Golgi apparatus membrane.; ",
"part_of": "Host trans-Golgi network.; ",
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Host trans-Golgi network.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0463",
"definition": "The host trans-Golgi network is a highly dynamic series of interconnected tubules and vesicles at the trans face of the host Golgi stack. The host trans-Golgi network functions in the processing and sorting of glycoproteins and glycolipids at the interface of the biosynthetic and endosomal pathways. The generation and maintenance of host apical and basolateral membranes rely on sorting events that occur in the host TGN. ",
"synonyms": "Host Golgi trans-face; Host TGN; Host trans-Golgi;; Host trans-Golgi complex.; ",
"content": "Host Golgi apparatus, host trans-Golgi network.",
"is_a": null,
"part_of": "Host Golgi apparatus.; ",
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Host thylakoid.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0449",
"definition": "The host thylakoid is a membranous cellular structure containing the photosynthetic pigments, reaction centers and electron-transport chain. In host chloroplast, thylakoids stack up to form the grana or stay as single cisternae and interconnect the grana. Thylakoid, where photosynthesis occurs, are found in chloroplasts, cyanelles and in photosynthetic bacteria where they are the extensive invaginations of the plasma membrane. ",
"synonyms": null,
"content": "Host thylakoid.",
"is_a": null,
"part_of": "Host cell.; ",
"keyword": "KW-1050",
"gene_ontology": "GO:0044159; host thylakoid; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Host synaptic vesicle membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0503",
"definition": "The host membrane surrounding a host synaptic vesicle ",
"synonyms": "Host synaptic vesicular membrane.; ",
"content": "Host cytoplasmic vesicle, host secretory vesicle, host synaptic vesicle membrane.",
"is_a": null,
"part_of": "Host synaptic vesicle.; ",
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Host synaptic vesicle.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0502",
"definition": "In a host synapse, host synaptic vesicles mediate the exocytosis of neurotransmitters and subsequent re-uptake by endocytosis of vesicular components. Re-uptake is a crucial element in the maintenance of host synaptic transmission in the nervous system. ",
"synonyms": null,
"content": "Host secretory vesicle, host synaptic vesicle.",
"is_a": "Host secretory vesicle.; ",
"part_of": "Host synapse.; ",
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Host synapse.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0435",
"definition": "Host synapses are the communicating cell-cell junctions that allow signals to pass from a host nerve cell to a target cell. In a chemical synapse, the signal is carried by a neurotransmitter which diffuses across a narrow synaptic cleft and activates a receptor on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, neuronal axon, a specialized region of a muscle or a secretory cell. In an electrical synapse, a direct connection is made between the cytoplasms of two cells via gap junctions. ",
"synonyms": null,
"content": "Host synapse.",
"is_a": null,
"part_of": null,
"keyword": "KW-1051",
"gene_ontology": "GO:0044221; host cell synapse; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Host smooth endoplasmic reticulum membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0445",
"definition": "The membrane surrounding the host smooth endoplasmic reticulum. ",
"synonyms": null,
"content": "Host smooth endoplasmic reticulum membrane.",
"is_a": "Host endoplasmic reticulum membrane.; ",
"part_of": "Host rough endoplasmic reticulum.; ",
"keyword": null,
"gene_ontology": "GO:0044171; host cell smooth endoplasmic reticulum membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Host smooth endoplasmic reticulum.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0444",
"definition": "The host smooth endoplasmic reticulum (host SER) is the portion of the host ER which is free of ribosomes. ",
"synonyms": "Host SER; Host smooth ER.; ",
"content": "Host smooth endoplasmic reticulum.",
"is_a": null,
"part_of": "Host endoplasmic reticulum.; ",
"keyword": null,
"gene_ontology": "GO:0044170; host cell smooth endoplasmic reticulum; ",
"annotation": null,
"references": null,
"links": null
}
]
}