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{
"count": 543,
"next": "https://cinder.proteo.info/api/subcellular_locations/?format=api&limit=20&offset=300",
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"results": [
{
"location_identifier": "Growth cone membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0289",
"definition": "The portion of the cell membrane surrounding a growth cone. ",
"synonyms": null,
"content": "Cell projection, growth cone membrane.",
"is_a": null,
"part_of": "Cell membrane.; Growth cone.; ",
"keyword": null,
"gene_ontology": "GO:0032584; growth cone membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Invadopodium membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0290",
"definition": "The portion of the cell membrane surrounding an invadopodium. ",
"synonyms": null,
"content": "Cell projection, invadopodium membrane.",
"is_a": null,
"part_of": "Cell membrane.; Invadopodium.; ",
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Lamellipodium.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0291",
"definition": "The lamellipodium is a broad, flat, veil-shaped cell protrusion formed at the leading edge of migrating cells. Lamellipodium contain a branched dendritic network of actin filaments having their barbed ends directed towards the cell membrane. It is associated with ameboid motility (or crawling motility). ",
"synonyms": "Lamellipodia; Veil.; ",
"content": "Cell projection, lamellipodium.",
"is_a": "Cell projection.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0030027; lamellipodium; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Lamellipodium membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0292",
"definition": "The portion of the cell membrane surrounding a lamellipodium. ",
"synonyms": null,
"content": "Cell projection, lamellipodium membrane.",
"is_a": null,
"part_of": "Cell membrane.; Lamellipodium.; ",
"keyword": null,
"gene_ontology": "GO:0031258; lamellipodium membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Microvillus.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0293",
"definition": "Microvilli are thin cylindrical dynamic cell projections containing a core bundle of actin filaments. They serve a diverse set of functions, such as increasing absorptive surface area in the epithelial brush border, tethering leukocytes to the surface of endothelial cells or participate in sperm-oocyte fusion. ",
"synonyms": "Microvilli.; ",
"content": "Cell projection, microvillus.",
"is_a": "Cell projection.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0005902; microvillus; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Microvillus membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0294",
"definition": "The portion of the cell membrane surrounding a microvillus. ",
"synonyms": "Microvillar membrane.; ",
"content": "Cell projection, microvillus membrane.",
"is_a": null,
"part_of": "Cell membrane.; Microvillus.; ",
"keyword": null,
"gene_ontology": "GO:0031528; microvillus membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Podosome.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0295",
"definition": "The podosome is a ring-like cell protrusion which mediates cell- extracellular matrix interactions. Podosomes are composed of an actin- bundle core, flanked by a ring containing adhesion proteins connected to the core via dome-like radial actin fibers. Podosomes are rich in actin filaments, matrix-degrading enzymes, focal adhesion molecules and molecules involved in vesicle trafficking. These structures protrudes into the extracellular matrix and are essential for invasion and metastasis. Classical podosomes are highly dynamic structures formed by cell types of monocytic origin, such as macrophages, dendritic cells, and osteoclasts. ",
"synonyms": null,
"content": "Cell projection, podosome.",
"is_a": "Cell junction.; Cell projection.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0002102; podosome; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Podosome membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0296",
"definition": "The portion of the cell membrane surrounding a podosome. ",
"synonyms": "Podosomal membrane.; ",
"content": "Cell projection, podosome membrane.",
"is_a": null,
"part_of": "Cell membrane.; Podosome.; ",
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Postsynaptic density.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0297",
"definition": "The postsynaptic density is a network of proteins within and adjacent to the postsynaptic membrane, consisting of anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components that spatially and functionally organize the neurotransmitter receptors at the synapse. In asymmetric synapses, the postsynaptic density is a thick electron dense network but in symmetric synapses this structure is thinner and not electron dense. ",
"synonyms": "Postsynaptic specialization; PSD.; ",
"content": "Postsynaptic density.",
"is_a": null,
"part_of": "Postsynapse.; ",
"keyword": null,
"gene_ontology": "GO:0014069; postsynaptic density; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Pseudopodium.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0298",
"definition": "The pseudopodium is a thick knobby cell protrusion. Pseudopodia are produced by polymerization of extensive dendritic meshwork of actin filaments along broad sectors of the cell surface. These temporary irregular and dynamic protrusion or retractile processes of a cell, are associated with ameboid movement (crawling). Pseudopodium, or \"false foot\", mostly used for motile protozoans is comparable to the 'lamellipodium' in vertebrate cells. ",
"synonyms": "Pseudopod; Pseudopodia.; ",
"content": "Cell projection, pseudopodium.",
"is_a": "Cell projection.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0031143; pseudopodium; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Pseudopodium membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0299",
"definition": "The portion of the cell membrane surrounding a pseudopodium. ",
"synonyms": null,
"content": "Cell projection, pseudopodium membrane.",
"is_a": null,
"part_of": "Cell membrane.; Pseudopodium.; ",
"keyword": null,
"gene_ontology": "GO:0031260; pseudopodium membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Ruffle.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0300",
"definition": "A ruffle is a cell protrusion at the leading edge of a crawling cell. Ruffles are supported by a microfilament meshwork. ",
"synonyms": null,
"content": "Cell projection, ruffle.",
"is_a": "Cell projection.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0001726; ruffle; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Ruffle membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0301",
"definition": "The portion of the cell membrane surrounding a ruffle. ",
"synonyms": null,
"content": "Cell projection, ruffle membrane.",
"is_a": null,
"part_of": "Cell membrane.; Ruffle.; ",
"keyword": null,
"gene_ontology": "GO:0032587; ruffle membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Stereocilium.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0302",
"definition": "The stereocilium is a finger-like projection forming the hair bundle on the apical surface of sensory hair cells in the cochlea. Stereocilia stiffness and function depend on the several hundreds of uniformly polarized and tightly cross-linked actin filaments. Stereocilia cytoskeleton shows continuous turnover with actin filament assembly occuring at the stereocilium tip and its disassembly at the base so that stereocilium length is maintained in a dynamic steady- state. This staircase-like bundle of stereocilia is responsible for mechanosensation and ultimately the perception of sound. ",
"synonyms": "Stereocilia.; ",
"content": "Cell projection, stereocilium.",
"is_a": "Cell projection.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0032420; stereocilium; ",
"annotation": null,
"references": "PubMed=17326148; DOI=10.1002/cm.20199;; ",
"links": null
},
{
"location_identifier": "Stereocilium membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0303",
"definition": "The stereocilium membrane is the portion of the cell membrane surrounding a stereocilium. ",
"synonyms": "Stereocilia membrane.; ",
"content": "Cell projection, stereocilium membrane.",
"is_a": null,
"part_of": "Cell membrane.; Stereocilium.; ",
"keyword": null,
"gene_ontology": "GO:0060171; stereocilium membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Cilium axoneme.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0304",
"definition": "The cilium axoneme is the most prominent structural component of the cilium. It consists of nine doublet microtubules, with all motile cilia - except those at the embryonic node - containing an additional central pair of microtubules. The axonemal microtubules of all cilia nucleate and extend from a basal body, a centriolar structure most often composed of a radial array of nine triplet microtubules. In most cells, basal bodies associate with cell membranes and cilia are assembled as 'extracellular' membrane-enclosed compartments. ",
"synonyms": "Ciliary axoneme.; ",
"content": "Cytoplasm, cytoskeleton, cilium axoneme.",
"is_a": null,
"part_of": "Cilium.; Cytoskeleton.; ",
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Cilium membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0305",
"definition": "The portion of the cell membrane surrounding the cilium. ",
"synonyms": "Ciliary membrane.; ",
"content": "Cell projection, cilium membrane.",
"is_a": null,
"part_of": "Cell membrane.; Cilium.; ",
"keyword": null,
"gene_ontology": "GO:0060170; ciliary membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Archaeal flagellum.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0306",
"definition": "The archaellum (archaeal flagellum) is the motility apparatus of archaea which propels the cell through liquid medium. The archaellum is the functional equivalent of the bacterial flagellum but its architecture, composition and mode of assembly is completely unrelated. The archaellum is thinner (10-15 nm) compared to the bacterial flagellum (18-24 nm). Its filament is assembled from archaellin subunits, which are N-glycosylated proteins. The archaellum is considered to be a type IV pilus-like structure. ",
"synonyms": "Archaeal flagella; Archaeal flagellar apparatus; Archaellum.; ",
"content": "Archaeal flagellum.",
"is_a": null,
"part_of": null,
"keyword": "KW-0974",
"gene_ontology": "GO:0097589; archaeal-type flagellum; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Bacterial flagellum.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0307",
"definition": "The flagellum of Bacteria is a long hair-like cell surface appendage. The flagellar apparatus consists of the flagellar filament made of polymerized flagellin (the propeller), the hook-like structure near the cell surface (the universal joint) and the basal body (the engine) which is a rod and a system of rings embedded in the cell envelope. The basal body and the hook anchor the whip-like filament to the cell surface. The flagellum is a rotating structure whose switches propels the cell through a liquid medium. ",
"synonyms": "Bacterial flagella; Bacterial flagellar apparatus.; ",
"content": "Bacterial flagellum.",
"is_a": null,
"part_of": null,
"keyword": "KW-0975",
"gene_ontology": "GO:0009288; bacterial-type flagellum; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Flagellum basal body.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0308",
"definition": "The basal body is a barrel-shaped microtubule-based structure required for the formation of flagella. Basal bodies, structuraly related to and often interconvertible with centrioles, serves as a nucleation site for axoneme growth. ",
"synonyms": "Flagellar basal body; Flagellar kinetosome; Flagellum kinetosome.; ",
"content": "Cytoplasm, cytoskeleton, flagellum basal body.",
"is_a": "Cilium basal body.; ",
"part_of": "Flagellum.; ",
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
}
]
}