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{
"count": 543,
"next": "https://cinder.proteo.info/api/subcellular_locations/?format=api&limit=20&offset=320&ordering=-synonyms",
"previous": "https://cinder.proteo.info/api/subcellular_locations/?format=api&limit=20&offset=280&ordering=-synonyms",
"results": [
{
"location_identifier": "Plastid outer membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0214",
"definition": "The outer membrane of a plastid is the membrane facing the cytoplasm. ",
"synonyms": "Outer plastidic membrane; Outer plastid membrane;; Plastidic outer membrane.; ",
"content": "Plastid outer membrane.",
"is_a": "Plastid membrane.; ",
"part_of": null,
"keyword": "KW-1002",
"gene_ontology": "GO:0009527; plastid outer membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Cell outer membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0040",
"definition": "The prokaryotic outer cell membrane is the selectively permeable membrane which separates the prokaryotic periplasm from its cell surroundings. Traditionally only Gram-negative bacteria were thought of as having an outer membrane, but recent work has shown some Actinobacteria, including Mycobacterium tuberculosis, as well as at least 1 archaea (Ignicoccus hospitalis) have a cell outer membrane. ",
"synonyms": "Outer membrane.; ",
"content": "Cell outer membrane.",
"is_a": "Membrane.; ",
"part_of": null,
"keyword": "KW-0998",
"gene_ontology": "GO:0009279; cell outer membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Organellar chromatophore stroma.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0353",
"definition": "The internal space enclosed by the organellar chromatophore double membrane but excluding the thylakoid space. This space, filled with a colorless hydrophilic matrix, contains DNA, ribosomes and some temporary products of photosynthesis; other biosynthetic functions that could also occur there include amino acid, fatty acid and some cofactor biosynthesis. Found exclusively in Paulinella species, which are photosynthetic thecate amoeba. ",
"synonyms": "Organellar chromatophore plasma.; ",
"content": "Plastid, organellar chromatophore stroma.",
"is_a": "Plastid stroma.; ",
"part_of": "Organellar chromatophore.; ",
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Nucleolus fibrillar center.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0497",
"definition": "The nucleolus fibrillar center (FC) is a sub-compartment of most metazoan nucleoli. The transcription of ribosomal RNA (rRNA) genes generates 2 structures that are found in all nucleoli: the dense fibrillar component (DFC) and the granular component (GC). The DFC contains newly synthesized preribosomal RNA and a collection of proteins; the GC is made up of nearly completed preribosomal particles destined for the cytoplasm. In most metazoans, but generally not in lower eukaryotes, a third component, the FC, can be seen. The FC is surrounded by the DFC. The zone of transcription from multiple copy rRNA genes is in the border region between these 2 structures. ",
"synonyms": "Nucleoli fibrillar center.; ",
"content": "Nucleus, nucleolus fibrillar center.",
"is_a": null,
"part_of": "Nucleolus.; ",
"keyword": null,
"gene_ontology": "GO:0001650; fibrillar center; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Nucleolus.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0188",
"definition": "The nucleolus is a non-membrane bound nuclear compartment found in eukaryotic cells which is the site of ribosome biogenesis. The interphase nucleolus is organized around the tandemly repeated genes for preribosomal RNA (rRNA). It is composed of at least 2 sub- compartments: the dense fibrillar component (DFC, also called pars fibrosa) and the granular component (GC or pars granulosa). The DFC contains newly synthesized preribosomal RNA and a collection of proteins; the GC is made up of nearly completed preribosomal particles destined for the cytoplasm. In most metazoans, but generally not in lower eukaryotes, a third component, the fibrillar center (FC), can be seen. Plant and animal nuclei can contain more than one nucleolus. ",
"synonyms": "Nucleoli.; ",
"content": "Nucleus, nucleolus.",
"is_a": null,
"part_of": "Nucleus.; ",
"keyword": null,
"gene_ontology": "GO:0005730; nucleolus; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Perinuclear region.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0198",
"definition": "The perinuclear region is the cytoplasmic region just around the nucleus. ",
"synonyms": "Nuclear periphery; Perinuclear region of cytoplasm.; ",
"content": "Cytoplasm, perinuclear region.",
"is_a": null,
"part_of": "Cytoplasm.; ",
"keyword": null,
"gene_ontology": "GO:0048471; perinuclear region of cytoplasm; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Nucleus outer membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0183",
"definition": "The outer membrane of the nucleus is the membrane facing the cytoplasm. In mammals, the outer nuclear membrane is continuous in many places with the rough endoplasmic reticulum and is dotted with ribosomes. ",
"synonyms": "Nuclear outer membrane; Outer nuclear membrane.; ",
"content": "Nucleus outer membrane.",
"is_a": "Nucleus membrane.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0005640; nuclear outer membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Nucleus.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0191",
"definition": "The nucleus is the most obvious organelle in any eukaryotic cell. It is a membrane-bound organelle surrounded by double membranes which contains most of the cell's genetic material. It communicates with the surrounding cytosol via numerous nuclear pores. ",
"synonyms": "Nuclear; Nuclei.; ",
"content": "Nucleus.",
"is_a": null,
"part_of": null,
"keyword": "KW-0539",
"gene_ontology": "GO:0005634; nucleus; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Nucleus membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0182",
"definition": "The membrane surrounding the nucleus. This term is used when it is not known if the protein is found in or associated with the inner or outer nuclear membrane. ",
"synonyms": "Nuclear membrane.; ",
"content": "Nucleus membrane.",
"is_a": "Membrane.; ",
"part_of": "Endomembrane system.; Nucleus envelope.; ",
"keyword": null,
"gene_ontology": "GO:0031965; nuclear membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Nucleus matrix.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0181",
"definition": "The nuclear matrix is a three-dimensional filamentous protein network, found in the nucleoplasm, which provides a structural framework for organising chromatin, while facilitating transcription and replication. ",
"synonyms": "Nuclear matrix; Nuclear scaffold; Nuclear skeleton.; ",
"content": "Nucleus matrix.",
"is_a": null,
"part_of": "Nucleus.; ",
"keyword": null,
"gene_ontology": "GO:0016363; nuclear matrix; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Nucleus lamina.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0180",
"definition": "The nuclear lamina is a meshwork of intermediate filament proteins called lamins and lamin-binding proteins that are embedded in the inner nuclear membrane. ",
"synonyms": "Nuclear lamina.; ",
"content": "Nucleus lamina.",
"is_a": null,
"part_of": "Nucleus envelope.; ",
"keyword": null,
"gene_ontology": "GO:0005652; nuclear lamina; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Nucleus intermembrane space.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0184",
"definition": "The nuclear intermembrane space is the space between the inner and outer nuclear membranes. ",
"synonyms": "Nuclear envelope lumen; Nuclear intermembrane space;; Nuclear periplasm; Nuclear periplasmic space; Nucleus envelope lumen;; Perinuclear space.; ",
"content": "Nucleus intermembrane space.",
"is_a": null,
"part_of": "Nucleus envelope.; ",
"keyword": null,
"gene_ontology": "GO:0005641; nuclear envelope lumen; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Nuclear pore complex.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0185",
"definition": "The nuclear pore complex (NPC) constitutes the exclusive means of nucleocytoplasmic transport in eukaryotes during interphase. NPCs allow the passive diffusion of ions and small molecules (up to about 20 kDa or 5 nm) and the active, nuclear transport receptor (karyopherin: importin and exportin)-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoprotein (RNPs), and ribosomal subunits (up to about 10 MDa) across the double-membrane nuclear envelope. NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. The NPC is composed of at least 30 distinct subunits, shows 8-fold rotational symmetry with specialized structures on the cyto- and nucleoplasmic side and in the nuclear envelope embedded core. The MW varies from about 44-60 MDa in S. cerevisiae to 60-120 MDa in vertebrates, yet the overall architecture is conserved. ",
"synonyms": "NPC; Nuclear pore.; ",
"content": "Nucleus, nuclear pore complex.",
"is_a": null,
"part_of": "Nucleus envelope.; ",
"keyword": "KW-0906",
"gene_ontology": "GO:0005643; nuclear pore; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Neuron projection.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0518",
"definition": "Prolongation or process extending from a nerve cell, such as an axon or a dendrite. Used when speaking of immature or developing neurons, especially of cells in culture, because it can be difficult to tell axons from dendrites before differentiation is complete. ",
"synonyms": "Neurite; Neuronal process.; ",
"content": "Cell projection, neuron projection.",
"is_a": "Cell projection.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0043005; neuron projection; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Sarcolemma.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0238",
"definition": "The sarcolemma is a specialized membrane which surrounds striated muscle fiber cells. It consists of a lipid bilayer typical of a plasma membrane and a thin outer coat of polysaccharide material, called glycocalyx, that contacts the basement membrane and allows the cell to anchor into the tissues that build and support muscle fibers. ",
"synonyms": "Myolemma.; ",
"content": "Cell membrane, sarcolemma.",
"is_a": "Cell membrane.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0042383; sarcolemma; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Myelin membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0176",
"definition": "The myelin membrane is the white matter coating our nerves, enabling them to conduct impulses between the brain and other parts of the body. It consists of a layer of proteins packed between two layers of lipids. This specialized cell membrane is produced by oligodendrocytes in the central nervous system, and Schwann cells in the peripheral nervous system. Myelin sheaths wrap themselves around axons, the threadlike extensions of neurons that make up nerve fibers. Each oligodendrocyte can myelinate several axons. The major function of myelin is to increase the velocity of propagation of nerve impulses. ",
"synonyms": "Myelin; Myelin sheath.; ",
"content": "Myelin membrane.",
"is_a": "Cell membrane.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0043209; myelin sheath; ",
"annotation": null,
"references": null,
"links": "https://www.myelin.org/; "
},
{
"location_identifier": "Microtubule organizing center.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0484",
"definition": "The microtubule organizing center (MTOC) is an intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules. ",
"synonyms": "MTOC.; ",
"content": "Cytoplasm, cytoskeleton, microtubule organizing center.",
"is_a": null,
"part_of": "Cytoskeleton.; ",
"keyword": null,
"gene_ontology": "GO:0005815; microtubule organizing center; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Mitosome outer membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0443",
"definition": "The outer membrane of a mitosome is the mitosomal membrane facing the cytoplasm. ",
"synonyms": "Mitosomal outer membrane; Outer mitosomal membrane.; ",
"content": "Mitosome outer membrane.",
"is_a": "Mitosome membrane.; ",
"part_of": null,
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Mitosome membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0442",
"definition": "The membrane surrounding a mitosome. This term is used when it is not known if the protein is found in or associated with the inner or outer mitosomal membrane. ",
"synonyms": "Mitosomal membrane.; ",
"content": "Mitosome membrane.",
"is_a": "Membrane.; ",
"part_of": "Mitosome envelope.; ",
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Mitosome matrix.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0441",
"definition": "The matrix of a mitosome is the mitosomal internal spaces enclosed by the inner membrane. ",
"synonyms": "Mitosomal matrix.; ",
"content": "Mitosome matrix.",
"is_a": null,
"part_of": "Mitosome.; ",
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
}
]
}