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{
"count": 543,
"next": "https://cinder.proteo.info/api/subcellular_locations/?format=api&limit=20&offset=320&ordering=location_identifier",
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"results": [
{
"location_identifier": "Interphotoreceptor matrix.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0146",
"definition": "In vertebrates, the photoreceptors are separated from the retinal pigment epithelium by the subretinal space, which contains a specialized extracellular material referred to as interphotoreceptor matrix. The IPM mediates key interactions between the photoreceptors and RPE including adhesion, phagocytosis, outer segment stability, nutrient exchange, development, and vitamin A trafficking in the visual cycle. ",
"synonyms": "IPM.; ",
"content": "Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix.",
"is_a": "Extracellular matrix.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0033165; interphotoreceptor matrix; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Invadopodium.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0148",
"definition": "The invadopodium is a localized and persitent cell protrusion similar to the highly dynamic podosome, but larger. These structures protrudes into the extracellular matrix. Invadopodial protrusions are enriched in integrins, tyrosine kinase signaling machinery, soluble and membrane proteases including matrix metalloproteases, actin and actin- associated proteins. Essential for physiological and pathological cell invasion and metastasis these structures are involved in focalized degradation of the extracellular matrix. Invadopodia form underneath the cell body, often close to the nucleus and proximal to the Golgi complex, and are rarely found at the cell periphery. Their half-life is quite extended. As invadopodia and podosomes are similar in appearance, location and composition, it is likely that a thin line separates these two entities in time and function. ",
"synonyms": "Invadopodia.; ",
"content": "Cell projection, invadopodium.",
"is_a": "Cell junction.; Cell projection.; ",
"part_of": null,
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": "PubMed=16546558; DOI=10.1016/j.ejcb.2005.09.005;; ",
"links": null
},
{
"location_identifier": "Invadopodium membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0290",
"definition": "The portion of the cell membrane surrounding an invadopodium. ",
"synonyms": null,
"content": "Cell projection, invadopodium membrane.",
"is_a": null,
"part_of": "Cell membrane.; Invadopodium.; ",
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Kinetochore.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0149",
"definition": "The kinetochore is a protein complex assembled on the centromeric region of DNA. It provides the major attachment point for the spindle microtubules during mitotic or meiotic division to pull the chromosomes apart. In monocentric chromosomes, the kinetochores of point centromeres bind a single microtubule and the larger kinetochores of regional centromeres interact with a number of microtubules. In holocentric chromosomes, the kinetochores bind the diffuse centromere along the length of the chromosomes. ",
"synonyms": null,
"content": "Chromosome, centromere, kinetochore.",
"is_a": null,
"part_of": "Centromere.; ",
"keyword": "KW-0995",
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Kinetoplast.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0150",
"definition": "The mitochondrial DNA of trypanosomatid protozoa is termed kinetoplast DNA (kDNA). kDNA is a massive network, composed of thousands of topologically interlocked DNA circles. Each cell contains one network condensed into a disk-shaped structure within the matrix of its single mitochondrion. The kDNA circles are of two types, maxicircles present in a few dozen copies and minicircles present in several thousand copies. ",
"synonyms": null,
"content": "Mitochondrion matrix, kinetoplast.",
"is_a": null,
"part_of": "Mitochondrion matrix.; ",
"keyword": "KW-0419",
"gene_ontology": "GO:0020023; kinetoplast; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Kinocilium.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0460",
"definition": "The kinocilium is an immotile primary cilium that is found at the apical surface of auditory receptor cells. Hair bundles, the mechanosensory device of the sensory hair cells, are composed of height-ranked rows of stereocilia and a single kinocilium that are interconnected by extracellular proteinaceous links. ",
"synonyms": "Kinocilia.; ",
"content": "Cell projection, kinocilium.",
"is_a": "Cilium.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0060091; kinocilium; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Lamellipodium.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0291",
"definition": "The lamellipodium is a broad, flat, veil-shaped cell protrusion formed at the leading edge of migrating cells. Lamellipodium contain a branched dendritic network of actin filaments having their barbed ends directed towards the cell membrane. It is associated with ameboid motility (or crawling motility). ",
"synonyms": "Lamellipodia; Veil.; ",
"content": "Cell projection, lamellipodium.",
"is_a": "Cell projection.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0030027; lamellipodium; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Lamellipodium membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0292",
"definition": "The portion of the cell membrane surrounding a lamellipodium. ",
"synonyms": null,
"content": "Cell projection, lamellipodium membrane.",
"is_a": null,
"part_of": "Cell membrane.; Lamellipodium.; ",
"keyword": null,
"gene_ontology": "GO:0031258; lamellipodium membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Late endosome.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0152",
"definition": "Late endosomes are pleiomorphic with cisternal, tubular and multivesicular regions. They are found in juxtanuclear regions and concentrated at the microtubule organizing center. They are an important sorting station in the endocytic pathway. Recycling to the plasma membrane and to the Golgi occurs in late endosomes. More acidic than early endosomes they are also loaded more slowly in a range of 4 to 30 minutes depending on the cell type. They can be distinguished from lysosome for their enrichment in M6PR. ",
"synonyms": null,
"content": "Late endosome.",
"is_a": null,
"part_of": "Endosome.; ",
"keyword": null,
"gene_ontology": "GO:0005770; late endosome; ",
"annotation": "Compartment specific marker: Rab7; Rab9; LBPA. ",
"references": null,
"links": null
},
{
"location_identifier": "Late endosome lumen.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0336",
"definition": "The late endosomal comaprtment bounded by the membrane of the late endosome. ",
"synonyms": "Late endosomal lumen.; ",
"content": "Late endosome lumen.",
"is_a": "Endosome lumen.; ",
"part_of": "Late endosome.; ",
"keyword": null,
"gene_ontology": "GO:0031906; late endosome lumen; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Late endosome membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0151",
"definition": "The membrane surrounding the late endosomes. ",
"synonyms": "Late endosomal membrane.; ",
"content": "Late endosome membrane.",
"is_a": "Endosome membrane.; ",
"part_of": "Late endosome.; ",
"keyword": null,
"gene_ontology": "GO:0031902; late endosome membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Lateral cell membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0153",
"definition": "The portion of the plasma membrane at the lateral side of the cell. ",
"synonyms": "Lateral plasma membrane.; ",
"content": "Lateral cell membrane.",
"is_a": null,
"part_of": "Cell membrane.; ",
"keyword": null,
"gene_ontology": "GO:0016328; lateral plasma membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Lipid droplet.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0154",
"definition": "The lipid droplet is a dynamic cytoplasmic organelle which consists of an heterogeneous macromolecular assembly of lipids and proteins covered by a unique phospholipid monolayer. Lipid droplets may play a role in lipid metabolism and storage, and they may be involved in the regulation of intracellular trafficking and signal transduction. ",
"synonyms": "Adiposome; Lipid bodies; Lipid body; Lipid particle;; Monolayer-surrounded lipid storage body; Oil bodies; Oil body;; Oleosome; Spherosome.; ",
"content": "Lipid droplet.",
"is_a": null,
"part_of": null,
"keyword": "KW-0551",
"gene_ontology": "GO:0005811; lipid droplet; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Lysosome.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0158",
"definition": "The lysosome is a membrane-limited organelle present in all eukaryotic cells, which contains a large number of hydrolytic enzymes that are used for degrading almost any kind of cellular constituent, including entire organelles. The mechanisms responsible for delivering cytoplasmic cargo to the lysosome/vacuole are known collectively as autophagy and play an important role in the maintenance of homeostasis. ",
"synonyms": null,
"content": "Lysosome.",
"is_a": null,
"part_of": null,
"keyword": "KW-0458",
"gene_ontology": "GO:0005764; lysosome; ",
"annotation": "Compartment specific marker: LAMP-1; LAMP-2?. ",
"references": null,
"links": null
},
{
"location_identifier": "Lysosome lumen.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0156",
"definition": "The lumen of a lysosome is the volume enclosed within the lysosomal membrane. ",
"synonyms": "Lysosomal lumen.; ",
"content": "Lysosome lumen.",
"is_a": null,
"part_of": "Lysosome.; ",
"keyword": null,
"gene_ontology": "GO:0043202; lysosomal lumen; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Lysosome membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0157",
"definition": "The membrane surrounding a lysosome. ",
"synonyms": "Lysosomal membrane.; ",
"content": "Lysosome membrane.",
"is_a": "Membrane.; ",
"part_of": "Endomembrane system.; Lysosome.; ",
"keyword": null,
"gene_ontology": "GO:0005765; lysosomal membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Lytic vacuole.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0159",
"definition": "The lytic vacuole is a plant specialized vacuole equivalent to animal lysosomes or yeast vacuoles, functioning as compartments for degradation and waste storage. ",
"synonyms": null,
"content": "Lytic vacuole.",
"is_a": "Vacuole.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0000323; lytic vacuole; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Magnetosome.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0510",
"definition": "A specialized, membrane-bound bacterial organelle that envelops nanometer-sized crystals of magnetic iron minerals. They form linear chains at midcell along the cellular motility axis. ",
"synonyms": null,
"content": "Magnetosome.",
"is_a": null,
"part_of": null,
"keyword": "KW-1281",
"gene_ontology": "GO:0110143; magnetosome; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Magnetosome lumen.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0511",
"definition": "The magnetosome lumen. ",
"synonyms": null,
"content": "Magnetosome, Magnetosome lumen.",
"is_a": null,
"part_of": "Magnetosome.; ",
"keyword": null,
"gene_ontology": "GO:0110145; magnetosome lumen; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Magnetosome membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0512",
"definition": "The magnetosome membrane. ",
"synonyms": null,
"content": "Magnetosome membrane.",
"is_a": "Membrane.; ",
"part_of": "Magnetosome.; ",
"keyword": null,
"gene_ontology": "GO:0110146; magnetosome membrane; ",
"annotation": null,
"references": null,
"links": null
}
]
}