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{
"count": 543,
"next": "https://cinder.proteo.info/api/subcellular_locations/?format=api&limit=20&offset=320&ordering=synonyms",
"previous": "https://cinder.proteo.info/api/subcellular_locations/?format=api&limit=20&offset=280&ordering=synonyms",
"results": [
{
"location_identifier": "Secretory vesicle membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0245",
"definition": "The membrane surrounding secretory vesicles. ",
"synonyms": "Secretory granule membrane.; ",
"content": "Cytoplasmic vesicle, secretory vesicle membrane.",
"is_a": "Cytoplasmic vesicle membrane.; ",
"part_of": "Secretory vesicle.; ",
"keyword": null,
"gene_ontology": "GO:0030658; transport vesicle membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Smooth endoplasmic reticulum.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0248",
"definition": "The smooth endoplasmic reticulum (SER) is the portion of the ER which is free of ribosomes. ",
"synonyms": "SER; Smooth ER.; ",
"content": "Smooth endoplasmic reticulum.",
"is_a": null,
"part_of": "Endoplasmic reticulum.; ",
"keyword": null,
"gene_ontology": "GO:0005790; smooth endoplasmic reticulum; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Spindle pole body.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0252",
"definition": "The spindle pole body is the microtubule organizing center (MTOC) in fungi, functionally equivalent to the animal cell centrosome. The SPB is responsible for the nucleation and organisation of microtubules. This may include the spindle microtubules required for chromosome segregation in mitosis and meiosis as well as the cytoplasmic interphase microtubules. ",
"synonyms": "SPB; Spindle polar body.; ",
"content": "Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.",
"is_a": null,
"part_of": "Microtubule organizing center.; ",
"keyword": null,
"gene_ontology": "GO:0005816; spindle pole body; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Spore membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0363",
"definition": "Protein associated with the membrane that surrounds the center or core of a spore, often called spore inner membrane in bacterial spores. ",
"synonyms": "Spore inner membrane.; ",
"content": "Spore membrane.",
"is_a": "Membrane.; ",
"part_of": "Spore.; ",
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Stereocilium.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0302",
"definition": "The stereocilium is a finger-like projection forming the hair bundle on the apical surface of sensory hair cells in the cochlea. Stereocilia stiffness and function depend on the several hundreds of uniformly polarized and tightly cross-linked actin filaments. Stereocilia cytoskeleton shows continuous turnover with actin filament assembly occuring at the stereocilium tip and its disassembly at the base so that stereocilium length is maintained in a dynamic steady- state. This staircase-like bundle of stereocilia is responsible for mechanosensation and ultimately the perception of sound. ",
"synonyms": "Stereocilia.; ",
"content": "Cell projection, stereocilium.",
"is_a": "Cell projection.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0032420; stereocilium; ",
"annotation": null,
"references": "PubMed=17326148; DOI=10.1002/cm.20199;; ",
"links": null
},
{
"location_identifier": "Stereocilium membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0303",
"definition": "The stereocilium membrane is the portion of the cell membrane surrounding a stereocilium. ",
"synonyms": "Stereocilia membrane.; ",
"content": "Cell projection, stereocilium membrane.",
"is_a": null,
"part_of": "Cell membrane.; Stereocilium.; ",
"keyword": null,
"gene_ontology": "GO:0060171; stereocilium membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Synaptic vesicle lumen.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0348",
"definition": "The synaptic vesicle compartment bounded by the membrane of a synaptic vesicle. ",
"synonyms": "Synaptic vesicular lumen.; ",
"content": "Cytoplasmic vesicle, secretory vesicle, synaptic vesicle lumen.",
"is_a": "Secretory vesicle lumen.; ",
"part_of": "Synaptic vesicle.; ",
"keyword": null,
"gene_ontology": "GO:0034592; synaptic vesicle lumen; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Synaptic vesicle membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0260",
"definition": "The membrane surrounding a synaptic vesicle. ",
"synonyms": "Synaptic vesicular membrane.; ",
"content": "Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane.",
"is_a": "Secretory vesicle membrane.; ",
"part_of": "Synaptic vesicle.; ",
"keyword": null,
"gene_ontology": "GO:0030672; synaptic vesicle membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Target cell cytoplasm.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0486",
"definition": "The contents of a target cell within the plasma membrane and which, in eukaryotic cells, surrounds the host nucleus. This term is used to describe a toxin located in the cytoplasm of a target cell. ",
"synonyms": "Target cytoplasm.; ",
"content": "Target cell, target cell cytoplasm.",
"is_a": "Target cell.; ",
"part_of": null,
"keyword": "KW-1266",
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Target cell membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0451",
"definition": "The target cell membrane is the selectively permeable membrane which separates the target cell cytoplasm from its surroundings. This term is used to describe a toxin located to the cell membrane of a target cell. ",
"synonyms": "Target cytoplasmic membrane; Target plasmalemma;; Target plasma membrane.; ",
"content": "Target cell membrane.",
"is_a": "Target membrane.; ",
"part_of": null,
"keyword": "KW-1052",
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Tegument membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0264",
"definition": "The membrane suroounding the tegument of schistosomes. ",
"synonyms": "Tegumental membrane.; ",
"content": "Tegument membrane.",
"is_a": "Membrane.; ",
"part_of": "Tegument.; ",
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Attachment organelle.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0020",
"definition": "The attachment organelle is a multifunctional polar structure found in several Mycoplasma species. This large and complex cell extension, whose predicted mass is greater than that of a vertebrate nuclear pore complex, is essential for adherence to host cells, is involved in gliding motility, and is associated with cell division. ",
"synonyms": "Terminal organelle.; ",
"content": "Cell projection, attachment organelle.",
"is_a": "Cell projection.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0033099; attachment organelle; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Attachment organelle membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0021",
"definition": "The membrane surrounding the attachment organelle. ",
"synonyms": "Terminal organelle membrane.; ",
"content": "Cell projection, attachment organelle membrane.",
"is_a": null,
"part_of": "Attachment organelle.; Cell membrane.; ",
"keyword": null,
"gene_ontology": "GO:0033111; attachment organelle membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Tight junction.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0265",
"definition": "The tight junction (TJ) is a dynamic, multifunctional complex which, together with adherens junctions and desmosomes, maintains the integrity of the epithelial cell layer(s) that protects multicellular organisms. TJ is located at the apical-most portion of the intercellular junction. It separates the apical and basolateral compartments of epithelia (preventing the lateral diffusion of lipids and proteins between the apical and basolateral domains of plasma membrane) and plays a key role in limiting paracellular permeability to ions and solutes in a charge and size selective manner. TJs appear as multiple strands of fibrils forming a continuous circumferential seal around cells. ",
"synonyms": "TJ; Zonula occludens.; ",
"content": "Cell junction, tight junction.",
"is_a": "Cell junction.; ",
"part_of": null,
"keyword": "KW-0796",
"gene_ontology": "GO:0005923; bicellular tight junction; ",
"annotation": "Add \"Cell membrane\" if the protein is clearly associated with the membrane. ",
"references": null,
"links": "http://celljunctions.med.nyu.edu/desmosomes/desframe.html; "
},
{
"location_identifier": "T-tubule.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0505",
"definition": "T-tubules are invaginations of the sarcolemma penetrating into the myocyte interior, forming a highly branched and interconnected network that makes junctions with the sarcoplasmic reticulum. T-tubules are selectively enriched with specific ion channels and proteins crucial in the development of calcium transients necessary in excitation- contraction coupling, thereby facilitating a fast and synchronous contraction across the entire cell volume. T-tubules are unique to striated muscle cells, i.e. skeletal and cardiac muscle cells. ",
"synonyms": "Transverse-axial tubular system; Transverse tubule.; ",
"content": "Cell membrane, sarcolemma, T-tubule.",
"is_a": null,
"part_of": "Sarcolemma.; ",
"keyword": null,
"gene_ontology": "GO:0030315; T-tubule; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Uropodium.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0141",
"definition": "The uropodium is a rigid membrane projection with related cytoskeletal components at the trailing edge of a lymphocyte or other cell in the process of migrating or being activated, found on the opposite side of the cell from the lamellipodium or immunological synapse, respectively. ",
"synonyms": "Uropod; Uropodia.; ",
"content": "Cell projection, uropodium.",
"is_a": "Cell projection.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0001931; uropod; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Vacuole lumen.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0270",
"definition": "The lumen of a vacuole is the area enclosed by the vacuolar membrane. ",
"synonyms": "Vacuolar lumen.; ",
"content": "Vacuole lumen.",
"is_a": null,
"part_of": "Vacuole.; ",
"keyword": null,
"gene_ontology": "GO:0005775; vacuolar lumen; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Vacuole membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0271",
"definition": "The membrane surrounding a vacuole. ",
"synonyms": "Vacuolar membrane.; ",
"content": "Vacuole membrane.",
"is_a": "Membrane.; ",
"part_of": "Endomembrane system.; Vacuole.; ",
"keyword": null,
"gene_ontology": "GO:0005774; vacuolar membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Virion tegument.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0273",
"definition": "The viral tegument is a protein structure that resides between the capsid and envelope of herpesviruses and which appears amorphous in electron micrographs. ",
"synonyms": "Viral tegument.; ",
"content": "Virion tegument.",
"is_a": null,
"part_of": "Virion.; ",
"keyword": "KW-0920",
"gene_ontology": "GO:0019033; viral tegument; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Z line.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0314",
"definition": "Z-disks are the lateral boundaries of a single sarcomere. In electron micrographs of cross striated muscle the Z line appears as a series of dark lines. They represent a key interface between the contractile apparatus and the cytoskeleton. The Z line (from the German \"Zwischen\") largely consists of alpha-actinin homodimers organized in an antiparallel fashion, thereby providing a backbone for the insertions of actin-based thin filaments, as well as titin and nebulin/nebulette. Z line of neighbouring sarcomeres are aligned in parallel and connected via the intermediate filament protein desmin. They maintain the actin filaments in a tetragonal lattice. ",
"synonyms": "Z-band; Z bodies; Z body; Z disc; Z-disc; Z disk; Z-disk; Z-line.; ",
"content": "Cytoplasm, myofibril, sarcomere, Z line.",
"is_a": null,
"part_of": "I band.; ",
"keyword": null,
"gene_ontology": "GO:0030018; Z disc; ",
"annotation": null,
"references": null,
"links": null
}
]
}