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{
"count": 543,
"next": "https://cinder.proteo.info/api/subcellular_locations/?format=api&limit=20&offset=380&ordering=-location_identifier",
"previous": "https://cinder.proteo.info/api/subcellular_locations/?format=api&limit=20&offset=340&ordering=-location_identifier",
"results": [
{
"location_identifier": "Focal adhesion.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0118",
"definition": "Focal adhesions are sites of tightest adhesion made to the underlying extracellular matrix by cells in culture. They serve a structural role, linking the ECM on the outside to the actin cytoskeleton on the inside. In addition, they are sites of signal transduction, initiating signaling pathways in response to adhesion. Focal adhesions are formed around a transmembrane core of an alpha-beta integrin heterodimer, which binds to a component of the extracellular matrix on its extracellular region, constitutes the site of anchorage of the actin cytoskeleton to the cytoplasmic side of the membrane, and mediates various intracellular signaling pathways. ",
"synonyms": null,
"content": "Cell junction, focal adhesion.",
"is_a": "Cell junction.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0005925; focal adhesion; ",
"annotation": "Add \"Cell membrane\" if the protein is clearly associated with the membrane. ",
"references": null,
"links": "http://www-cellbio.med.unc.edu/grad/depttest/burridge.htm; "
},
{
"location_identifier": "Flagellum membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0115",
"definition": "The portion of the cell membrane surrounding the flagellum, a long whip-like or feathery structure which propels the cell through a liquid medium. ",
"synonyms": "Flagellar membrane.; ",
"content": "Cell projection, cilium, flagellum membrane.",
"is_a": "Cilium membrane.; ",
"part_of": "Flagellum.; ",
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Flagellum basal body.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0308",
"definition": "The basal body is a barrel-shaped microtubule-based structure required for the formation of flagella. Basal bodies, structuraly related to and often interconvertible with centrioles, serves as a nucleation site for axoneme growth. ",
"synonyms": "Flagellar basal body; Flagellar kinetosome; Flagellum kinetosome.; ",
"content": "Cytoplasm, cytoskeleton, flagellum basal body.",
"is_a": "Cilium basal body.; ",
"part_of": "Flagellum.; ",
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Flagellum axoneme.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0114",
"definition": "The flagellum axoneme is the most prominent structural component of the flagellum, which is a long whip-like or feathery structure which propels the cell through a liquid medium. The flagellum axoneme consists of a characteristic axial '9+2' microtubular array. ",
"synonyms": "Flagellar axoneme.; ",
"content": "Cytoplasm, cytoskeleton, flagellum axoneme.",
"is_a": "Cilium axoneme.; ",
"part_of": "Flagellum.; ",
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Flagellum.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0117",
"definition": "The flagellum is a long whip-like or feathery structure which propels the cell through a liquid medium. This motile cilium is produced by the unicellular eukaryotes, and by the motile male gametes of many eukaryotic organisms. The flagella commonly have a characteristic axial '9+2' microtubular array (axoneme) and bends are generated along the length of the flagellum by restricted sliding of the nine outer doublets. ",
"synonyms": "Flagella; Motile cilia; Motile cilium; Undulipodia; Undulipodium.; ",
"content": "Cell projection, cilium, flagellum.",
"is_a": "Cilium.; ",
"part_of": null,
"keyword": "KW-0282",
"gene_ontology": "GO:0031514; motile cilium; ",
"annotation": null,
"references": null,
"links": "http://www.ciliome.com; "
},
{
"location_identifier": "Flagellar pocket.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0116",
"definition": "The flagellar pocket is a structure found in trypanosomes. The flagellar pocket is formed by an invagination in the plasma membrane where the flagellum emerges from the cell body. This pocket provides the portal through which most of the dynamic interactions with the host occur. ",
"synonyms": null,
"content": "Flagellar pocket.",
"is_a": null,
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0020016; ciliary pocket; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Fimbrium.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0113",
"definition": "A fimbrium or pilus is a hair-like, non-flagellar, polymeric filamentous appendage that extend from the bacterial or archaeal cell surface, such as type 1 pili, P-pili, type IV pili or curli. Pili perform a variety of functions, including surface adhesion, motility, cell-cell interactions, biofilm formation, conjugation, DNA uptake, and twitching motility. ",
"synonyms": "Fimbria; Pili; Pilus.; ",
"content": "Fimbrium.",
"is_a": null,
"part_of": null,
"keyword": "KW-0281",
"gene_ontology": "GO:0009289; pilus; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Filopodium tip.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0470",
"definition": "The end of the filopodium distal to the body of the cell. The filopodium is a thin, tubular, finger-like cell protrusion filled with straight bundled, crosslinked actin filaments having their barbed ends directed towards the cell membrane. ",
"synonyms": "Filopodia tip; Microspike tip.; ",
"content": "Cell projection, filopodium tip.",
"is_a": null,
"part_of": "Filopodium.; ",
"keyword": null,
"gene_ontology": "GO:0032433; filopodium tip; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Filopodium membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0287",
"definition": "The portion of the cell membrane surrounding the filopodium. The filopodium is a thin, tubular, finger-like cell protrusion filled with straight bundled, crosslinked actin filaments having their barbed ends directed towards the cell membrane. ",
"synonyms": "Filopodia membrane; Microspike membrane.; ",
"content": "Cell projection, filopodium membrane.",
"is_a": null,
"part_of": "Cell membrane.; Filopodium.; ",
"keyword": null,
"gene_ontology": "GO:0031527; filopodium membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Filopodium.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0286",
"definition": "The filopodium is a thin, tubular, finger-like cell protrusion filled with straight bundled, crosslinked actin filaments having their barbed ends directed towards the cell membrane. Filopodium are observed at the advancing front of the migrating cell and are implicated in cell motility as well as in cell-substrate adhesion. Filopodia explore the environment and form nascent adhesive structures in response to external signaling cues. These long and highly dynamic protrusions, which can extend and retract, are involved in mesenchymal migration. They are observed in many cell types, such as amoebae, keratinocytes, fibroblasts and in neurite growth cones. ",
"synonyms": "Filopodia; Microspike.; ",
"content": "Cell projection, filopodium.",
"is_a": "Cell projection.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0030175; filopodium; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Extracellular vesicle membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0500",
"definition": "The membrane surrounding an extracellular vesicle. ",
"synonyms": null,
"content": "Extracellular vesicle membrane.",
"is_a": "Membrane.; ",
"part_of": "Extracellular vesicle.; ",
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Extracellular vesicle.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0499",
"definition": "Extracellular vesicles are vesicles that have been released by cells. ",
"synonyms": "Microparticle.; ",
"content": "Extracellular vesicle.",
"is_a": "Vesicle.; ",
"part_of": null,
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": "PubMed=24769233; DOI=10.1016/j.jprot.2014.04.028;; ",
"links": null
},
{
"location_identifier": "Extracellular space.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0112",
"definition": "The extracellular space is the space outside of the cell membrane but part of a multicellular organism. The term is typically used for a secreted protein that remains associated with the cell, e.g. as part of the extracellular matrix. It is not used for a protein that is secreted into the blood stream (or other body fluids) of eukaryotic, multicellular organisms, such as insulin or fibroblast growth factors. ",
"synonyms": "Intercellular space.; ",
"content": "Secreted, extracellular space.",
"is_a": null,
"part_of": "Secreted.; ",
"keyword": null,
"gene_ontology": "GO:0005576; extracellular region; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Extracellular matrix.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0111",
"definition": "The extracellular matrix (ECM) is a vague term used to refer to all the material surrounding cells in a multicellular organism, except circulating fluids such as blood or lymph. In some cases, the ECM accounts for more of the organism's bulk than its cells. In plants, arthropods and fungi the ECM is primarily composed of nonliving material such as cellulose or chitin. In vertebrates the ECM consists of a complex network including the basement membrane, collage, elastin, proteoglycans and hyaluronan. ",
"synonyms": "Proteinaceous extracellular matrix.; ",
"content": "Secreted, extracellular space, extracellular matrix.",
"is_a": null,
"part_of": "Extracellular space.; ",
"keyword": "KW-0272",
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Extracellular exosome.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0466",
"definition": "Exosomes are 30-120 nm microvesicles of endocytic origin secreted by most cell types and found in abundance in body fluids, including blood, saliva, urine, and breast milk. They contain various molecular constituents of their cell of origin, including proteins and nucleic acids, and carry this cargo between diverse locations in the body. These microvesicles form by budding into the lumen of the multivesicular bodies (MVBs) and are released to extracellular fluids by fusion of MVBs with the plasma membrane. ",
"synonyms": "Extracellular vesicular exosome.; ",
"content": "Secreted, extracellular exosome.",
"is_a": null,
"part_of": "Secreted.; ",
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": null,
"links": "http://exocarta.ludwig.edu.au/; "
},
{
"location_identifier": "Etioplast stroma.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0330",
"definition": "The etioplast stroma is the space enclosed by the double membrane of an etioplast but excluding the prothylakoid space. It contains the etioplast DNA. ",
"synonyms": null,
"content": "Plastid, etioplast stroma.",
"is_a": "Plastid stroma.; ",
"part_of": "Etioplast.; ",
"keyword": null,
"gene_ontology": "GO:0009578; etioplast stroma; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Etioplast membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0329",
"definition": "The membrane surrounding the etioplast, a plastid found in plants grown in the dark. Also used when it is not clear in which etioplast membrane a protein is found. ",
"synonyms": null,
"content": "Plastid, etioplast membrane.",
"is_a": "Plastid membrane.; ",
"part_of": "Etioplast.; ",
"keyword": null,
"gene_ontology": "GO:0034426; etioplast membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Etioplast.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0110",
"definition": "The etioplast is a plastid found in plants grown in the dark. ",
"synonyms": null,
"content": "Plastid, etioplast.",
"is_a": "Plastid.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0009513; etioplast; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Esterosome membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0108",
"definition": "The membrane surrounding the esterosome, a crystalline inclusion body is a vesicle filled with crystals of proteins showing sequence similarities with various esterases. ",
"synonyms": "Esterosomal membrane.; ",
"content": "Cytoplasmic vesicle, esterosome membrane.",
"is_a": "Cytoplasmic vesicle membrane.; ",
"part_of": "Esterosome.; Endomembrane system.; ",
"keyword": null,
"gene_ontology": "GO:0033118; esterosome membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Esterosome lumen.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0328",
"definition": "The esterosomal compartment bounded by the esterosomal membrane. ",
"synonyms": "Esterosomal lumen.; ",
"content": "Cytoplasmic vesicle, esterosome lumen.",
"is_a": "Cytoplasmic vesicle lumen.; ",
"part_of": "Esterosome.; ",
"keyword": null,
"gene_ontology": "GO:0034467; esterosome lumen; ",
"annotation": null,
"references": null,
"links": null
}
]
}