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{
"count": 543,
"next": "https://cinder.proteo.info/api/subcellular_locations/?format=api&limit=20&offset=400&ordering=-location_identifier",
"previous": "https://cinder.proteo.info/api/subcellular_locations/?format=api&limit=20&offset=360&ordering=-location_identifier",
"results": [
{
"location_identifier": "Esterosome.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0109",
"definition": "The esterosome is a crystalline inclusion body. This vesicle is filled with crystals of proteins showing sequence similarities with various esterases. The enclosing membrane has the characteristics of RER. ",
"synonyms": null,
"content": "Cytoplasmic vesicle, esterosome.",
"is_a": "Cytoplasmic vesicle.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0033117; esterosome; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Endosome membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0100",
"definition": "The membrane surrounding the endosome. Endosomes are highly dynamic membrane systems involved in transport within the cell, they receive endocytosed cell membrane molecules and sort them for either degradation or recycling back to the cell surface. ",
"synonyms": "Endosomal membrane.; ",
"content": "Endosome membrane.",
"is_a": "Membrane.; ",
"part_of": "Endosome.; Endomembrane system.; ",
"keyword": null,
"gene_ontology": "GO:0010008; endosome membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Endosome lumen.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0327",
"definition": "The endosomal compartment bounded by the endosomal membrane. ",
"synonyms": "Endosomal lumen.; ",
"content": "Endosome lumen.",
"is_a": null,
"part_of": "Endosome.; ",
"keyword": null,
"gene_ontology": "GO:0031904; endosome lumen; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Endosome.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0101",
"definition": "Endosomes are highly dynamic membrane systems involved in transport within the cell, they receive endocytosed cell membrane molecules and sort them for either degradation or recycling back to the cell surface. They also receive newly synthesised proteins destined for vacuolar/lysosomal compartments. In certain cell types, endosomal multivesicular bodies may fuse with the cell surface in an exocytic manner. These released vesicles are called exosomes. ",
"synonyms": null,
"content": "Endosome.",
"is_a": null,
"part_of": null,
"keyword": "KW-0967",
"gene_ontology": "GO:0005768; endosome; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Endoplasmic reticulum membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0097",
"definition": "The membrane surrounding the endoplasmic reticulum (ER). The endoplasmic reticulum is an extensive network of membrane tubules, vesicles and flattened cisternae (sac-like structures) found throughout the eukaryotic cell, especially those responsible for the production of hormones and other secretory products. ",
"synonyms": null,
"content": "Endoplasmic reticulum membrane.",
"is_a": "Membrane.; ",
"part_of": "Endoplasmic reticulum.; Endomembrane system.; ",
"keyword": null,
"gene_ontology": "GO:0005789; endoplasmic reticulum membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Endoplasmic reticulum lumen.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0096",
"definition": "The lumen of the endoplasmic reticulum (ER) is the area enclosed by the endoplasmic reticulum membrane, an extensive network of membrane tubules, vesicles and flattened cisternae (sac-like structures) found throughout the eukaryotic cell, especially those responsible for the production of hormones and other secretory products. ",
"synonyms": null,
"content": "Endoplasmic reticulum lumen.",
"is_a": null,
"part_of": "Endoplasmic reticulum.; ",
"keyword": null,
"gene_ontology": "GO:0005788; endoplasmic reticulum lumen; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Endoplasmic reticulum-Golgi intermediate compartment membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0099",
"definition": "The membrane surrounding the ER-Golgi intermediate compartment, which is a collection of tubulovesicular membrane clusters in the vicinity of ER exit sites. ",
"synonyms": "ERGIC membrane; ER-Golgi intermediate compartment membrane;; IC membrane; Intermediate compartment membrane;; Vesiculo-tubular cluster membrane; VTC membrane.; ",
"content": "Endoplasmic reticulum-Golgi intermediate compartment membrane.",
"is_a": "Membrane.; ",
"part_of": "Endoplasmic reticulum-Golgi intermediate compartment.; Endomembrane system.; ",
"keyword": null,
"gene_ontology": "GO:0033116; endoplasmic reticulum-Golgi intermediate compartment membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Endoplasmic reticulum-Golgi intermediate compartment lumen.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0326",
"definition": "The ERGIC compartment bounded by the ERGIC membrane. ",
"synonyms": "ERGIC lumen; ER-Golgi intermediate compartment lumen; IC lumen;; Intermediate compartment lumen; Vesiculo-tubular cluster lumen;; VTC lumen.; ",
"content": "Endoplasmic reticulum-Golgi intermediate compartment lumen.",
"is_a": null,
"part_of": "Endoplasmic reticulum-Golgi intermediate compartment.; ",
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Endoplasmic reticulum-Golgi intermediate compartment.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0098",
"definition": "The ER-Golgi intermediate compartment is a collection of tubulovesicular membrane clusters in the vicinity of ER exit sites. The ERGIC mediates transport between the endoplasmic reticulum and the Golgi and is the first anterograde/retrograde sorting station in the secretory pathway. ERGIC has not been observed in yeast and plants. ",
"synonyms": "ERGIC; ER-Golgi intermediate compartment; IC;; Intermediate compartment; Vesiculo-tubular cluster; VTC.; ",
"content": "Endoplasmic reticulum-Golgi intermediate compartment.",
"is_a": null,
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0005793; endoplasmic reticulum-Golgi intermediate compartment; ",
"annotation": "Compartment specific marker: LMAN1/ERGIC-53 (Also called P-58). ",
"references": null,
"links": null
},
{
"location_identifier": "Endoplasmic reticulum.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0095",
"definition": "The endoplasmic reticulum (ER) is an extensive network of membrane tubules, vesicles and flattened cisternae (sac-like structures) found throughout the eukaryotic cell, especially those responsible for the production of hormones and other secretory products. The membrane is a continuation of the outer nuclear membrane, it encloses the cytosol cisternal spaces (or internal lumen), which are continuous with the nuclear periplasmic space. The ER sustains many general functions, including protein synthesis, protein modification, protein folding, insertion of membrane proteins, sequestration of calcium, production of phospholipids and steroids and transport of proteins destined for membranes and secretion. ",
"synonyms": null,
"content": "Endoplasmic reticulum.",
"is_a": null,
"part_of": null,
"keyword": "KW-0256",
"gene_ontology": "GO:0005783; endoplasmic reticulum; ",
"annotation": "Compartment specific marker: PDI; calreticulin; calnexin. ",
"references": null,
"links": null
},
{
"location_identifier": "Endomembrane system.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0147",
"definition": "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi apparatus, vesicles and cell membrane and nuclear envelope. The endomembrane system does not include the membranes of mitochondria or plastids. ",
"synonyms": "Endomembrane.; ",
"content": "Endomembrane system.",
"is_a": "Membrane.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0012505; endomembrane system; ",
"annotation": "Try to use a child/narrower/more specific term instead ",
"references": null,
"links": null
},
{
"location_identifier": "Encapsulin nanocompartment.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0550",
"definition": "Proteinaceous polyhedral shells that encapsulate enzymes. The selectively permeable organelles protect their contents from their surrounding milieu and/or the milieu from reactants in their interior. The self-assembling, 25-42 nm nanocompartment shell, unlike larger bacterial microcompartments, is made of only 1 protein, and has only a few proteins inside. Shells 25 nm in diameter are made of 60 monomers, shells 32 nm are made of 180 monomers, while shells 42 nm in diameter are made of 240 monomers with T=1, T=3 or T=4 icosahedral symmetry respectively. The shell protein has an HK97-like fold and probably evolved from a viral protein. Artificial encapsulin nanocompartments can be expressed and filled with cargo proteins for biotechnological uses. They are found in many bacterial and a few archaeal phyla. In anammox bacteria they may be located inside the anammoxosome. ",
"synonyms": null,
"content": "Encapsulin nanocompartment.",
"is_a": null,
"part_of": null,
"keyword": "KW-1284",
"gene_ontology": "GO:0140737; encapsulin nanocompartment; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Early endosome membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0093",
"definition": "The membrane surrounding the early endosomes, which form a tubulovesicular network spread throughout the cortical cytoplasm of the cell. ",
"synonyms": "Early endosomal membrane.; ",
"content": "Early endosome membrane.",
"is_a": "Endosome membrane.; ",
"part_of": "Early endosome.; ",
"keyword": null,
"gene_ontology": "GO:0031901; early endosome membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Early endosome lumen.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0337",
"definition": "The early endosomal compartment bounded by the membrane of early endosomes, which form a tubulovesicular network spread throughout the cortical cytoplasm of the cell. ",
"synonyms": "Early endosomal lumen.; ",
"content": "Early endosome lumen.",
"is_a": "Endosome lumen.; ",
"part_of": "Early endosome.; ",
"keyword": null,
"gene_ontology": "GO:0031905; early endosome lumen; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Early endosome.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0094",
"definition": "Early endosomes form a tubulovesicular network spread throughout the cortical cytoplasm of the cell. Early endosomes are the primary sorting station in the endocytic pathway from which endocytosed molecules can be recycled back to the cell membrane or targeted to degradation in the lysosomes. Loaded by endocytosed molecules in 1 to 4 minutes, their acidic luminal pH around 6.0 allows ligand release from recycling receptors. ",
"synonyms": null,
"content": "Early endosome.",
"is_a": null,
"part_of": "Endosome.; ",
"keyword": null,
"gene_ontology": "GO:0005769; early endosome; ",
"annotation": "Compartment specific marker: EEA1; Rab5; Rab4. ",
"references": null,
"links": null
},
{
"location_identifier": "Dynein axonemal particle.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0542",
"definition": "Dynein axonemal particles are ciliated cell-specific cytoplasmic membrane-less organelles, where dynein axonemal assembly factors (DNAAFs) and chaperones flux through rapidly while dynein subunits are stably retained. May act in storage or assembly of axonemal dyneins for rapid deployment to cilia. ",
"synonyms": "DynAP.; ",
"content": "Dynein axonemal particle.",
"is_a": null,
"part_of": "Cytoplasm.; ",
"keyword": null,
"gene_ontology": "GO:0120293; dynein axonemal particle; ",
"annotation": null,
"references": "PubMed=33263282; DOI=10.7554/elife.38497;; ",
"links": null
},
{
"location_identifier": "Desmosome.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0092",
"definition": "A desmosome (DS) is a button-like adhesion complex that stabilizes epithelial sheets by anchoring the intermediate filament cytoskeleton to the cell junction. Desmosomes are found particularly in tissues subjected to mechanical stress. ",
"synonyms": "DS; Macula adherens.; ",
"content": "Cell junction, desmosome.",
"is_a": "Cell junction.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0030057; desmosome; ",
"annotation": "Add \"Cell membrane\" if the protein is clearly associated with the membrane. ",
"references": null,
"links": "http://celljunctions.med.nyu.edu/desmosomes/desframe.html; "
},
{
"location_identifier": "Dendritic spine membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0285",
"definition": "The portion of the cell membrane surrounding the dendritic spine, a small, club-like cell protrusion from neuronal dendrites that form the postsynaptic component of most excitatory synapses in the brain. ",
"synonyms": null,
"content": "Cell projection, dendritic spine membrane.",
"is_a": "Postsynaptic cell membrane.; ",
"part_of": "Dendritic spine.; ",
"keyword": null,
"gene_ontology": "GO:0032591; dendritic spine membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Dendritic spine.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0284",
"definition": "A dendritic spine is a small, club-like cell protrusion from neuronal dendrites that form the postsynaptic component of most excitatory synapses in the brain. Spines are complex, dynamic structures that contain a dense array of cytoskeletal, transmembrane, and scaffolding molecules. Despite their modest size, most spines contain at least some form of smooth endoplasmic reticulum, which in the largest spines takes the form of a specialized organelle called the \"spine apparatus\". These cell protrusions play a critical role in synaptic transmission and plasticity. ",
"synonyms": "Postsynaptic dendritic spine; Spine.; ",
"content": "Cell projection, dendritic spine.",
"is_a": "Postsynapse.; ",
"part_of": "Neuron projection.; ",
"keyword": null,
"gene_ontology": "GO:0043197; dendritic spine; ",
"annotation": null,
"references": "PubMed=16443821; DOI=10.1152/physiol.00042.2005;; ",
"links": null
},
{
"location_identifier": "Dendrite.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0283",
"definition": "The dendrite is a short and typically branched process extending from the cell body of a neuron that receives and integrates signals coming from axons of other neurons, and conveys the resulting signal to the body of the cell. ",
"synonyms": null,
"content": "Cell projection, dendrite.",
"is_a": "Neuron projection.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0030425; dendrite; ",
"annotation": null,
"references": null,
"links": null
}
]
}