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{
"count": 543,
"next": "https://cinder.proteo.info/api/subcellular_locations/?format=api&limit=20&offset=400&ordering=synonyms",
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"results": [
{
"location_identifier": "Dendrite.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0283",
"definition": "The dendrite is a short and typically branched process extending from the cell body of a neuron that receives and integrates signals coming from axons of other neurons, and conveys the resulting signal to the body of the cell. ",
"synonyms": null,
"content": "Cell projection, dendrite.",
"is_a": "Neuron projection.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0030425; dendrite; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Dendritic spine membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0285",
"definition": "The portion of the cell membrane surrounding the dendritic spine, a small, club-like cell protrusion from neuronal dendrites that form the postsynaptic component of most excitatory synapses in the brain. ",
"synonyms": null,
"content": "Cell projection, dendritic spine membrane.",
"is_a": "Postsynaptic cell membrane.; ",
"part_of": "Dendritic spine.; ",
"keyword": null,
"gene_ontology": "GO:0032591; dendritic spine membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Early endosome.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0094",
"definition": "Early endosomes form a tubulovesicular network spread throughout the cortical cytoplasm of the cell. Early endosomes are the primary sorting station in the endocytic pathway from which endocytosed molecules can be recycled back to the cell membrane or targeted to degradation in the lysosomes. Loaded by endocytosed molecules in 1 to 4 minutes, their acidic luminal pH around 6.0 allows ligand release from recycling receptors. ",
"synonyms": null,
"content": "Early endosome.",
"is_a": null,
"part_of": "Endosome.; ",
"keyword": null,
"gene_ontology": "GO:0005769; early endosome; ",
"annotation": "Compartment specific marker: EEA1; Rab5; Rab4. ",
"references": null,
"links": null
},
{
"location_identifier": "Encapsulin nanocompartment.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0550",
"definition": "Proteinaceous polyhedral shells that encapsulate enzymes. The selectively permeable organelles protect their contents from their surrounding milieu and/or the milieu from reactants in their interior. The self-assembling, 25-42 nm nanocompartment shell, unlike larger bacterial microcompartments, is made of only 1 protein, and has only a few proteins inside. Shells 25 nm in diameter are made of 60 monomers, shells 32 nm are made of 180 monomers, while shells 42 nm in diameter are made of 240 monomers with T=1, T=3 or T=4 icosahedral symmetry respectively. The shell protein has an HK97-like fold and probably evolved from a viral protein. Artificial encapsulin nanocompartments can be expressed and filled with cargo proteins for biotechnological uses. They are found in many bacterial and a few archaeal phyla. In anammox bacteria they may be located inside the anammoxosome. ",
"synonyms": null,
"content": "Encapsulin nanocompartment.",
"is_a": null,
"part_of": null,
"keyword": "KW-1284",
"gene_ontology": "GO:0140737; encapsulin nanocompartment; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Endoplasmic reticulum.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0095",
"definition": "The endoplasmic reticulum (ER) is an extensive network of membrane tubules, vesicles and flattened cisternae (sac-like structures) found throughout the eukaryotic cell, especially those responsible for the production of hormones and other secretory products. The membrane is a continuation of the outer nuclear membrane, it encloses the cytosol cisternal spaces (or internal lumen), which are continuous with the nuclear periplasmic space. The ER sustains many general functions, including protein synthesis, protein modification, protein folding, insertion of membrane proteins, sequestration of calcium, production of phospholipids and steroids and transport of proteins destined for membranes and secretion. ",
"synonyms": null,
"content": "Endoplasmic reticulum.",
"is_a": null,
"part_of": null,
"keyword": "KW-0256",
"gene_ontology": "GO:0005783; endoplasmic reticulum; ",
"annotation": "Compartment specific marker: PDI; calreticulin; calnexin. ",
"references": null,
"links": null
},
{
"location_identifier": "Endoplasmic reticulum lumen.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0096",
"definition": "The lumen of the endoplasmic reticulum (ER) is the area enclosed by the endoplasmic reticulum membrane, an extensive network of membrane tubules, vesicles and flattened cisternae (sac-like structures) found throughout the eukaryotic cell, especially those responsible for the production of hormones and other secretory products. ",
"synonyms": null,
"content": "Endoplasmic reticulum lumen.",
"is_a": null,
"part_of": "Endoplasmic reticulum.; ",
"keyword": null,
"gene_ontology": "GO:0005788; endoplasmic reticulum lumen; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Endoplasmic reticulum membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0097",
"definition": "The membrane surrounding the endoplasmic reticulum (ER). The endoplasmic reticulum is an extensive network of membrane tubules, vesicles and flattened cisternae (sac-like structures) found throughout the eukaryotic cell, especially those responsible for the production of hormones and other secretory products. ",
"synonyms": null,
"content": "Endoplasmic reticulum membrane.",
"is_a": "Membrane.; ",
"part_of": "Endoplasmic reticulum.; Endomembrane system.; ",
"keyword": null,
"gene_ontology": "GO:0005789; endoplasmic reticulum membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Endosome.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0101",
"definition": "Endosomes are highly dynamic membrane systems involved in transport within the cell, they receive endocytosed cell membrane molecules and sort them for either degradation or recycling back to the cell surface. They also receive newly synthesised proteins destined for vacuolar/lysosomal compartments. In certain cell types, endosomal multivesicular bodies may fuse with the cell surface in an exocytic manner. These released vesicles are called exosomes. ",
"synonyms": null,
"content": "Endosome.",
"is_a": null,
"part_of": null,
"keyword": "KW-0967",
"gene_ontology": "GO:0005768; endosome; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Esterosome.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0109",
"definition": "The esterosome is a crystalline inclusion body. This vesicle is filled with crystals of proteins showing sequence similarities with various esterases. The enclosing membrane has the characteristics of RER. ",
"synonyms": null,
"content": "Cytoplasmic vesicle, esterosome.",
"is_a": "Cytoplasmic vesicle.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0033117; esterosome; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Etioplast.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0110",
"definition": "The etioplast is a plastid found in plants grown in the dark. ",
"synonyms": null,
"content": "Plastid, etioplast.",
"is_a": "Plastid.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0009513; etioplast; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Etioplast membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0329",
"definition": "The membrane surrounding the etioplast, a plastid found in plants grown in the dark. Also used when it is not clear in which etioplast membrane a protein is found. ",
"synonyms": null,
"content": "Plastid, etioplast membrane.",
"is_a": "Plastid membrane.; ",
"part_of": "Etioplast.; ",
"keyword": null,
"gene_ontology": "GO:0034426; etioplast membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Etioplast stroma.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0330",
"definition": "The etioplast stroma is the space enclosed by the double membrane of an etioplast but excluding the prothylakoid space. It contains the etioplast DNA. ",
"synonyms": null,
"content": "Plastid, etioplast stroma.",
"is_a": "Plastid stroma.; ",
"part_of": "Etioplast.; ",
"keyword": null,
"gene_ontology": "GO:0009578; etioplast stroma; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Extracellular vesicle membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0500",
"definition": "The membrane surrounding an extracellular vesicle. ",
"synonyms": null,
"content": "Extracellular vesicle membrane.",
"is_a": "Membrane.; ",
"part_of": "Extracellular vesicle.; ",
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Flagellar pocket.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0116",
"definition": "The flagellar pocket is a structure found in trypanosomes. The flagellar pocket is formed by an invagination in the plasma membrane where the flagellum emerges from the cell body. This pocket provides the portal through which most of the dynamic interactions with the host occur. ",
"synonyms": null,
"content": "Flagellar pocket.",
"is_a": null,
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0020016; ciliary pocket; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Focal adhesion.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0118",
"definition": "Focal adhesions are sites of tightest adhesion made to the underlying extracellular matrix by cells in culture. They serve a structural role, linking the ECM on the outside to the actin cytoskeleton on the inside. In addition, they are sites of signal transduction, initiating signaling pathways in response to adhesion. Focal adhesions are formed around a transmembrane core of an alpha-beta integrin heterodimer, which binds to a component of the extracellular matrix on its extracellular region, constitutes the site of anchorage of the actin cytoskeleton to the cytoplasmic side of the membrane, and mediates various intracellular signaling pathways. ",
"synonyms": null,
"content": "Cell junction, focal adhesion.",
"is_a": "Cell junction.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0005925; focal adhesion; ",
"annotation": "Add \"Cell membrane\" if the protein is clearly associated with the membrane. ",
"references": null,
"links": "http://www-cellbio.med.unc.edu/grad/depttest/burridge.htm; "
},
{
"location_identifier": "Gas vesicle.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0125",
"definition": "Gas vesicles (GV) are hollow, watertight, gas-permeable proteinaceous nanostructures found in some microorganisms. During planktonic growth they allow positioning of the organism at a favorable depth for light or nutrient acquisition. By regulating their relative GV content, aquatic microbes can perform vertical migrations. The GV is impermeable to liquid water but is highly permeable to gases and is normally filled with air. As they scatter light, they may also protect against UV light. Two main proteins are present in the gas vesicle: GvpA, an extremely hydrophobic protein which makes the ribs that form the structure, and GvpC, which binds to the outside of the ribs, helps shape the GV and stiffens it against collapse. ",
"synonyms": null,
"content": "Gas vesicle.",
"is_a": null,
"part_of": null,
"keyword": "KW-0304",
"gene_ontology": "GO:0031411; gas vesicle; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Gas vesicle lumen.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0331",
"definition": "The gas vesicle compartment bounded by the protein shell of the gas vesicle. ",
"synonyms": null,
"content": "Gas vesicle lumen.",
"is_a": null,
"part_of": "Gas vesicle.; ",
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Gas vesicle shell.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0126",
"definition": "The protein shell surrounding a gas vesicle. ",
"synonyms": null,
"content": "Gas vesicle shell.",
"is_a": null,
"part_of": "Gas vesicle.; ",
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Gem.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0127",
"definition": "Gems are nuclear bodies, often found paired or juxtaposed to Cajal bodies, called gems for \"gemini of CBs\". It is not clear if Cajal bodes and gems are distinct nuclear bodies or if they should be considered as two manifestations of the same structure. ",
"synonyms": null,
"content": "Nucleus, gem.",
"is_a": "Nuclear body.; ",
"part_of": "Nucleus.; ",
"keyword": null,
"gene_ontology": "GO:0097504; Gemini of coiled bodies; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Glycosome.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0129",
"definition": "The glycosome is a specialized peroxisome found in all members of the protist order Kinetoplastida examined. Nine enzymes involved in glucose and glycerol metabolism are associated with these organelles. These enzymes are involved in pathways which, in other organisms, are usually located in the cytosol. ",
"synonyms": null,
"content": "Glycosome.",
"is_a": "Peroxisome.; ",
"part_of": null,
"keyword": "KW-0327",
"gene_ontology": "GO:0020015; glycosome; ",
"annotation": null,
"references": null,
"links": null
}
]
}