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{
"count": 543,
"next": "https://cinder.proteo.info/api/subcellular_locations/?format=api&limit=20&offset=480",
"previous": "https://cinder.proteo.info/api/subcellular_locations/?format=api&limit=20&offset=440",
"results": [
{
"location_identifier": "Filopodium tip.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0470",
"definition": "The end of the filopodium distal to the body of the cell. The filopodium is a thin, tubular, finger-like cell protrusion filled with straight bundled, crosslinked actin filaments having their barbed ends directed towards the cell membrane. ",
"synonyms": "Filopodia tip; Microspike tip.; ",
"content": "Cell projection, filopodium tip.",
"is_a": null,
"part_of": "Filopodium.; ",
"keyword": null,
"gene_ontology": "GO:0032433; filopodium tip; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Pseudopodium tip.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0471",
"definition": "The end of the pseudopodium distal to the body of the cell. ",
"synonyms": null,
"content": "Cell projection, pseudopodium tip.",
"is_a": null,
"part_of": "Pseudopodium.; ",
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Bleb.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0472",
"definition": "These cellular membrane protrusions are the result of actomyosin contractions of the cortex, which cause either transient detachment of the cell membrane from the actin cortex or a rupture in the actin cortex. Then, cytosol streams out of the cell body and inflates the newly formed bleb. Once expansion slows, an actin cortex is reconstituted. Retraction is powered by myosin motor proteins. Blebbing is a common feature of cell physiology during cell movement, cytokinesis, cell spreading and apoptosis. ",
"synonyms": null,
"content": "Cell projection, bleb.",
"is_a": "Cell projection.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0032059; bleb; ",
"annotation": null,
"references": "PubMed=17318224; DOI=10.1038/nrm2122;; ",
"links": null
},
{
"location_identifier": "Phagocytic cup.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0473",
"definition": "Cup-shaped invaginations of the cell membrane that subsequently close at their distal margins to form phagosomes during phagocytosis. By progression of its rim along the particle surface, this phagocytic cup envelops and eventually encloses the particle by separation of the phagosome membrane from the cell membrane. Filamentous actin accumulates between the outer and inner leaflet of the cup membrane and is most strongly enriched at the rim of the cup, the site of its protrusion. ",
"synonyms": null,
"content": "Cell projection, phagocytic cup.",
"is_a": "Cell projection.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0001891; phagocytic cup; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Host glyoxysome.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0474",
"definition": "The host glyoxysome is a plant peroxisome, especially found in germinating seeds, involved in the breakdown and conversion of fatty acids to acetyl-CoA for the glyoxylate bypass. Since it is also rich in catalase, the glyoxysome may be related to the microbodies or peroxisomes or derived from them. ",
"synonyms": null,
"content": "Host glyoxysome.",
"is_a": "Host peroxisome.; ",
"part_of": null,
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Host peroxisome.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0475",
"definition": "The host peroxisome is a small eukaryotic organelle limited by a single membrane, specialized for carrying out oxidative reactions. Contains mainly peroxidases, several other oxidases and catalase. The catalase regulates the contents of the produced toxic hydrogen peroxide thus protecting the cell. Beta-oxidation of fatty acids is another major function of peroxisomes. In plants and fungi this degradation occurs only in this cellular compartment. ",
"synonyms": null,
"content": "Host peroxisome.",
"is_a": null,
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0120149; host cell peroxisome; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "A band.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0476",
"definition": "The appearance of the striated muscle is created by a pattern of alternating dark A bands and light I bands. A bands comprise thick filaments of myosin and proteins that bind myosin. They are bisected by the H zone, a paler region where the thick and the thin filaments do not overlap. The exact center of the A band is termed the M line. ",
"synonyms": "A-band; A line.; ",
"content": "Cytoplasm, myofibril, sarcomere, A band.",
"is_a": null,
"part_of": "Sarcomere.; ",
"keyword": null,
"gene_ontology": "GO:0031672; A band; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "H zone.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0477",
"definition": "The A band of a sarcomer is bisected by a paler zone, the H zone, where the thick and the thin filaments do not overlap. At the center of the H zone is the M line. ",
"synonyms": "H band; H-band; H disc; H disk.; ",
"content": "Cytoplasm, myofibril, sarcomere, H zone.",
"is_a": null,
"part_of": "A band.; ",
"keyword": null,
"gene_ontology": "GO:0031673; H zone; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "I band.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0478",
"definition": "The appearance of the striated muscle is created by a pattern of alternating dark A bands and light I bands. I bands are composed of thin actin filaments and proteins that bind actin and they are bisected by the Z line. The thin filaments extend in each direction from the Z-disk, where they do not overlap the thick filaments, they create the light I band. ",
"synonyms": "I-band; I disc; I disk.; ",
"content": "Cytoplasm, myofibril, sarcomere, I band.",
"is_a": null,
"part_of": "Sarcomere.; ",
"keyword": null,
"gene_ontology": "GO:0031674; I band; ",
"annotation": null,
"references": null,
"links": "http://www.sarcomere.org/; "
},
{
"location_identifier": "Cyanelle envelope.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0479",
"definition": "The envelope of a cyanelle comprises the inner and outer cyanelle membrane including the intermembrane space and the vestigal peptidoglycan layer. ",
"synonyms": null,
"content": "Plastid, cyanelle envelope.",
"is_a": "Plastid envelope.; ",
"part_of": "Cyanelle.; ",
"keyword": null,
"gene_ontology": "GO:0033112; cyanelle envelope; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Cyanelle inner membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0480",
"definition": "The inner membrane of a cyanelle is the membrane which separates the cyanelle stroma from the intermembrane space. ",
"synonyms": null,
"content": "Plastid, cyanelle inner membrane.",
"is_a": "Cyanelle membrane.; Plastid inner membrane.; ",
"part_of": "Cyanelle envelope.; ",
"keyword": null,
"gene_ontology": "GO:0036012; cyanelle inner membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Cyanelle intermembrane space.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0481",
"definition": "The intermembrane space between the inner and the outer cyanelle membranes, it includes the vestigial peptidoglycan layer. ",
"synonyms": "Cyanelle periplasm.; ",
"content": "Plastid, cyanelle intermembrane space.",
"is_a": "Plastid intermembrane space.; ",
"part_of": "Cyanelle envelope.; ",
"keyword": null,
"gene_ontology": "GO:0036014; cyanelle intermembrane space; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Cyanelle outer membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0482",
"definition": "The outer membrane of a cyanelle is the cyanelle membrane facing the cytoplasm. ",
"synonyms": null,
"content": "Plastid, cyanelle outer membrane.",
"is_a": "Cyanelle membrane.; Plastid outer membrane.; ",
"part_of": "Cyanelle envelope.; ",
"keyword": null,
"gene_ontology": "GO:0036013; cyanelle outer membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Host chloroplast envelope.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0483",
"definition": "The envelope of a host chloroplast comprises the inner and outer chloroplast membrane including the intermembrane space. ",
"synonyms": "Host chloroplastic envelope.; ",
"content": "Host chloroplast envelope.",
"is_a": null,
"part_of": null,
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Microtubule organizing center.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0484",
"definition": "The microtubule organizing center (MTOC) is an intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules. ",
"synonyms": "MTOC.; ",
"content": "Cytoplasm, cytoskeleton, microtubule organizing center.",
"is_a": null,
"part_of": "Cytoskeleton.; ",
"keyword": null,
"gene_ontology": "GO:0005815; microtubule organizing center; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Centriolar satellite.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0485",
"definition": "Centriolar satellites are nonmembranous, electron-dense and spherical cytoplasmic granules of about 70-100 nm in diameter, occurring around centrosomes in most vertebrate cell types. They contain a number of centrosomal proteins. Centriolar satellites have the ability to move along microtubules, toward their minus ends, i.e. toward centrosomes. Their number increase during interphase and decrease during mitosis. ",
"synonyms": "Massule; satellites.; ",
"content": "Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite.",
"is_a": null,
"part_of": "Centrosome.; ",
"keyword": null,
"gene_ontology": "GO:0034451; centriolar satellite; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Target cell cytoplasm.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0486",
"definition": "The contents of a target cell within the plasma membrane and which, in eukaryotic cells, surrounds the host nucleus. This term is used to describe a toxin located in the cytoplasm of a target cell. ",
"synonyms": "Target cytoplasm.; ",
"content": "Target cell, target cell cytoplasm.",
"is_a": "Target cell.; ",
"part_of": null,
"keyword": "KW-1266",
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Target cell.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0487",
"definition": "A cell including the cell membrane and any external encapsulating of another cell. This term is used to describe a toxin located in the structures such as the cell wall and cell envelope that is the target. ",
"synonyms": null,
"content": "Target cell.",
"is_a": null,
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0044216; obsolete other organism cell; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Inflammasome.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0488",
"definition": "Inflammasomes are supramolecular micron-sized complexes that assemble in the cytosol adjacent to the nucleus in response to pathogens and other damage-associated signals. The inflammasome assembly leads to the activation of proinflammatory procaspases, hence is usually involved in innate immunity and inflammation. The core of inflammasomes consists of at least 2 components: a signal sensor and an effector inflammatory caspase (mostly CASP1). However, most inflammasomes contain a third element, an adaptor (often ASC/PYCARD). The interaction between the sensor component and the adaptor initiates speck formation (nucleation) which greatly enhances further addition of soluble adaptor molecules to the speck in a prion-like polymerization process. The kinetic properties of the adaptor aggregation have been shown to generate a rapid 'all-or-none' response, this is why only one speck by cell is observed. ",
"synonyms": "ASC focus; ASC speck.; ",
"content": "Inflammasome.",
"is_a": null,
"part_of": "Cytosol.; ",
"keyword": "KW-1271",
"gene_ontology": "GO:0061702; canonical inflammasome complex; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Bacterial extracellular vesicle.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0489",
"definition": "Small membrane vesicle (< 1 um) that buds off a prokaryotic cell's plasma membrane, able to carry proteins, phospholipids, lipopolysaccharides, nucleic acids, viruses, etc. Bacterial extracellular vesicles are important in intercellular communication and pathogenesis, and can exist within host cells. ",
"synonyms": "Bacterial membrane vesicle; Membrane vesicle; Microvesicle.; ",
"content": "Extracellular vesicle, bacterial extracellular vesicle.",
"is_a": "Extracellular vesicle.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0097691; bacterial extracellular vesicle; ",
"annotation": null,
"references": null,
"links": null
}
]
}