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{
"count": 543,
"next": "https://cinder.proteo.info/api/subcellular_locations/?format=api&limit=20&offset=500",
"previous": "https://cinder.proteo.info/api/subcellular_locations/?format=api&limit=20&offset=460",
"results": [
{
"location_identifier": "Midbody ring.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0490",
"definition": "The midbody ring is the central region of the midbody characterized by a gap in alpha-tubulin staining, although interdigitating microtubules persist through the gap. It is thought that high local protein density masks tubulin epitopes known to be present. The midbody ring serves as a scaffold for a wide variety of structural and regulatory proteins required for completion of cytokinesis. ",
"synonyms": "Flemming body; Stembody.; ",
"content": "Midbody, Midbody ring.",
"is_a": "Midbody.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0090543; Flemming body; ",
"annotation": "Some authors consider that Flemming body and Midbody are synonyms. This is not the case in UniProtKB, where we use Flemming body as a synonym for Midbody ring, a specific part of the midbody. If you have doubt, use the broader term, Midbody. ",
"references": null,
"links": null
},
{
"location_identifier": "Anammoxosome.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0491",
"definition": "The anammoxosome is a large intracytoplasmic compartment bounded by a single bilayer, ladderane-lipid-containing membrane present in bacteria that perform anaerobic ammonium oxidation (anammox). This organelle is the site of the anammox process, in which nitrite is used as the electron acceptor in the conversion of ammonium to dinitrogen (N2) gas and water. Anammox bacteria belong to the phylum Planctomycetes and are recognized as major players in the global nitrogen cycle. ",
"synonyms": null,
"content": "Anammoxosome.",
"is_a": null,
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0044222; anammoxosome; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Anammoxosome membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0492",
"definition": "The membrane of the anammoxosome, a single bilayer membrane that contains unusual lipids, i.e. the so-called ladderane lipids, which appear to be unique for anammox bacteria. ",
"synonyms": null,
"content": "Anammoxosome membrane.",
"is_a": "Membrane.; ",
"part_of": "Anammoxosome.; ",
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Nuclear body.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0494",
"definition": "Nuclear body is a collective term for several nuclear, extra- nucleolar, non-membrane-bound sub-compartments, including, but not limited to Cajal bodies, Gemini of Cajal bodies (gems), nuclear speckles and PML bodies. Nuclear bodies are visible as distinct spots in the nucleoplasm. They can vary in number and size depending on the cell line and the type of nuclear body. ",
"synonyms": null,
"content": "Nucleus, nuclear body.",
"is_a": null,
"part_of": "Nucleus.; ",
"keyword": null,
"gene_ontology": "GO:0016604; nuclear body; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Cytoplasmic ribonucleoprotein granule.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0495",
"definition": "Cytoplasmic ribonucleoprotein granule is a collective term for distinct protein and RNA foci inside the cytoplasm, including processing bodies (P-bodies), U snRNP bodies (U-bodies), stress granules, neuronal ribonucleoprotein granule (neuronal transport granule) and germ granules (germline granules). ",
"synonyms": "Cytoplasmic mRNP granule; Cytoplasmic mRNP granules; mRNP granule;; mRNP granules.; ",
"content": "Cytoplasm, Cytoplasmic ribonucleoprotein granule.",
"is_a": null,
"part_of": "Cytoplasm.; ",
"keyword": null,
"gene_ontology": "GO:0036464; cytoplasmic ribonucleoprotein granule; ",
"annotation": "The synonym \"cytoplasmic body/bodies\" is also used to indicate cytoplasmic speckles or foci. In this case, the location \"Cytoplasmic ribonucleoprotein granule\" does not apply. ",
"references": "PubMed=25531407; DOI=10.4161/15476286.2014.972208;; ",
"links": null
},
{
"location_identifier": "Stress granule.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0496",
"definition": "Stress granules are dense non-membrane bound aggregations in the cytosol composed of proteins and RNAs that appear when the cell is under stress. The aggregates are mostly composed of stalled translation initiation complexes. They are 100-200 nm in size. Stress granules can also precipitate the formation of toxic protein aggregates such as those seen during the progression of certain types of neurological disease. ",
"synonyms": null,
"content": "Cytoplasm, Stress granule.",
"is_a": "Cytoplasmic ribonucleoprotein granule.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0010494; cytoplasmic stress granule; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Nucleolus fibrillar center.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0497",
"definition": "The nucleolus fibrillar center (FC) is a sub-compartment of most metazoan nucleoli. The transcription of ribosomal RNA (rRNA) genes generates 2 structures that are found in all nucleoli: the dense fibrillar component (DFC) and the granular component (GC). The DFC contains newly synthesized preribosomal RNA and a collection of proteins; the GC is made up of nearly completed preribosomal particles destined for the cytoplasm. In most metazoans, but generally not in lower eukaryotes, a third component, the FC, can be seen. The FC is surrounded by the DFC. The zone of transcription from multiple copy rRNA genes is in the border region between these 2 structures. ",
"synonyms": "Nucleoli fibrillar center.; ",
"content": "Nucleus, nucleolus fibrillar center.",
"is_a": null,
"part_of": "Nucleolus.; ",
"keyword": null,
"gene_ontology": "GO:0001650; fibrillar center; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Vesicle.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0498",
"definition": "A vesicle is a small structure consisting of fluid enclosed by a lipid bilayer. Vesicles form naturally during the processes of secretion (exocytosis), uptake (endocytosis) and transport of materials within the cytoplasm or between cells, and exist both within the cell and in the extracellular space. ",
"synonyms": null,
"content": "Vesicle.",
"is_a": null,
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0031982; vesicle; ",
"annotation": null,
"references": "PubMed=24769233; DOI=10.1016/j.jprot.2014.04.028;; ",
"links": null
},
{
"location_identifier": "Extracellular vesicle.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0499",
"definition": "Extracellular vesicles are vesicles that have been released by cells. ",
"synonyms": "Microparticle.; ",
"content": "Extracellular vesicle.",
"is_a": "Vesicle.; ",
"part_of": null,
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": "PubMed=24769233; DOI=10.1016/j.jprot.2014.04.028;; ",
"links": null
},
{
"location_identifier": "Extracellular vesicle membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0500",
"definition": "The membrane surrounding an extracellular vesicle. ",
"synonyms": null,
"content": "Extracellular vesicle membrane.",
"is_a": "Membrane.; ",
"part_of": "Extracellular vesicle.; ",
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Stress fiber.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0501",
"definition": "Stress fibers are contractile actomyosin bundles found in non-muscle cells, in eukaryotes, mostly in animals. They are composed of bundles of 10 to 30 actin filaments (microfilaments), crosslinked by alpha- actinin, and non-muscle myosin. They are often anchored to focal adhesions, that connect the extracellular matrix to the actin cytoskeleton. Stress fibers play an essential role in cell contractility, governing cell morphology, adhesion, and migration. In non-motile cells, stress fibers are usually thick and relatively stable. By contrast, highly motile cells typically contain fewer, thinner and more dynamic stress fibers. Stress fibers can be divided into at least 4 different categories : dorsal and ventral stress fibers, transverse arcs and the perinuclear actin cap. ",
"synonyms": null,
"content": "Cytoplasm, cytoskeleton, stress fiber.",
"is_a": null,
"part_of": "Cytoskeleton.; ",
"keyword": null,
"gene_ontology": "GO:0001725; stress fiber; ",
"annotation": "Mostly in animal, non-muscle cells. ",
"references": null,
"links": null
},
{
"location_identifier": "Host synaptic vesicle.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0502",
"definition": "In a host synapse, host synaptic vesicles mediate the exocytosis of neurotransmitters and subsequent re-uptake by endocytosis of vesicular components. Re-uptake is a crucial element in the maintenance of host synaptic transmission in the nervous system. ",
"synonyms": null,
"content": "Host secretory vesicle, host synaptic vesicle.",
"is_a": "Host secretory vesicle.; ",
"part_of": "Host synapse.; ",
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Host synaptic vesicle membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0503",
"definition": "The host membrane surrounding a host synaptic vesicle ",
"synonyms": "Host synaptic vesicular membrane.; ",
"content": "Host cytoplasmic vesicle, host secretory vesicle, host synaptic vesicle membrane.",
"is_a": null,
"part_of": "Host synaptic vesicle.; ",
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Host secretory vesicle.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0504",
"definition": "The host secretory vesicle is a host vesicle that mediates the vesicular transport of cargo - e.g. hormones or neurotransmitters - from an organelle to specific sites at the host cell membrane, where it docks and fuses to release its content. ",
"synonyms": null,
"content": "Host cytoplasmic vesicle, host secretory vesicle.",
"is_a": "Host cytoplasmic vesicle.; ",
"part_of": null,
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "T-tubule.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0505",
"definition": "T-tubules are invaginations of the sarcolemma penetrating into the myocyte interior, forming a highly branched and interconnected network that makes junctions with the sarcoplasmic reticulum. T-tubules are selectively enriched with specific ion channels and proteins crucial in the development of calcium transients necessary in excitation- contraction coupling, thereby facilitating a fast and synchronous contraction across the entire cell volume. T-tubules are unique to striated muscle cells, i.e. skeletal and cardiac muscle cells. ",
"synonyms": "Transverse-axial tubular system; Transverse tubule.; ",
"content": "Cell membrane, sarcolemma, T-tubule.",
"is_a": null,
"part_of": "Sarcolemma.; ",
"keyword": null,
"gene_ontology": "GO:0030315; T-tubule; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Host vacuole.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0506",
"definition": "The host vacuole is a fluid-filled, membrane-bound compartment in the cytoplasm. The precise form and function of vacuoles may vary between phyla. They are employed for a variety of purposes, including storage, as a degradative compartment, cell size control, secretion and following phagocytosis. ",
"synonyms": null,
"content": "Host vacuole.",
"is_a": null,
"part_of": "Host cell.; ",
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Host pathogen-containing vacuole.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0507",
"definition": "A host-derived vacuole formed upon pathogen internalization by a host cell, within which the pathogen resides. The pathogen extensively modifies the vacuole membrane and contents, as well as its fate, in the process protecting the pathogen from destruction. ",
"synonyms": "Pathogen inclusion.; ",
"content": "Host vacuole, host pathogen-containing vacuole.",
"is_a": null,
"part_of": "Host vacuole.; ",
"keyword": null,
"gene_ontology": "GO:0140220; pathogen-containing vacuole; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Host pathogen-containing vacuole lumen.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0508",
"definition": "The volume enclosed in a host-derived vacuole formed upon pathogen internalization by a host cell. ",
"synonyms": "Pathogen inclusion lumen.; ",
"content": "Host vacuole, host pathogen-containing vacuole, host pathogen-containing vacuole lumen.",
"is_a": "Host pathogen-containing vacuole.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0140222; pathogen-containing vacuole lumen; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Host pathogen-containing vacuole membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0509",
"definition": "The host-derived membrane which encloses a vacuole formed upon pathogen internalization by a host cell. ",
"synonyms": "Pathogen inclusion membrane.; ",
"content": "Host vacuole, host pathogen-containing vacuole, host pathogen-containing vacuole membrane.",
"is_a": "Host membrane.; ",
"part_of": "Host pathogen-containing vacuole.; ",
"keyword": null,
"gene_ontology": "GO:0140221; pathogen-containing vacuole membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Magnetosome.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0510",
"definition": "A specialized, membrane-bound bacterial organelle that envelops nanometer-sized crystals of magnetic iron minerals. They form linear chains at midcell along the cellular motility axis. ",
"synonyms": null,
"content": "Magnetosome.",
"is_a": null,
"part_of": null,
"keyword": "KW-1281",
"gene_ontology": "GO:0110143; magnetosome; ",
"annotation": null,
"references": null,
"links": null
}
]
}