HTTP 200 OK
Allow: GET, POST, HEAD, OPTIONS
Content-Type: application/json
Vary: Accept
{
"count": 543,
"next": "https://cinder.proteo.info/api/subcellular_locations/?format=api&limit=20&offset=520&ordering=-synonyms",
"previous": "https://cinder.proteo.info/api/subcellular_locations/?format=api&limit=20&offset=480&ordering=-synonyms",
"results": [
{
"location_identifier": "cis-Golgi network.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0067",
"definition": "The cis-Golgi network is an extensive tubulovesicular network bound to the cis face of the Golgi stack and which function is to receive process the biosynthetic output from the ER. ",
"synonyms": "CGN; cis-Golgi; cis-Golgi complex; Golgi cis-face.; ",
"content": "Golgi apparatus, cis-Golgi network.",
"is_a": null,
"part_of": "Golgi apparatus.; ",
"keyword": null,
"gene_ontology": "GO:0005801; cis-Golgi network; ",
"annotation": "The CGN is not the cis cisternae of the Golgi stack. Compartment specific marker: GOLGA2/GM130. ",
"references": null,
"links": null
},
{
"location_identifier": "Bud tip.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0030",
"definition": "The bud tip is the distal tip of the bud opposite to the site of attachment to the mother cell. ",
"synonyms": "Cellular bud tip.; ",
"content": "Bud tip.",
"is_a": null,
"part_of": "Bud.; ",
"keyword": null,
"gene_ontology": "GO:0005934; cellular bud tip; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Bud neck.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0029",
"definition": "The bud neck is a constriction between the mother and the daughter cell (bud) in an organism that reproduces by budding. This structure comprises the septin ring, an hourglass-shaped collar around the mother-bud neck, which splits into two rings flanking the division plane at cytokinesis and that acts as a diffusion barrier to maintain polarity factors in the bud and as a scaffold to recruit actomyosin contractile ring components. ",
"synonyms": "Cellular bud neck.; ",
"content": "Bud neck.",
"is_a": null,
"part_of": "Bud.; ",
"keyword": null,
"gene_ontology": "GO:0005935; cellular bud neck; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Bud membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0028",
"definition": "The membrane surrounding a bud. ",
"synonyms": "Cellular bud membrane.; ",
"content": "Bud membrane.",
"is_a": null,
"part_of": "Bud.; Cell membrane.; ",
"keyword": null,
"gene_ontology": "GO:0033101; cellular bud membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Cell projection.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0280",
"definition": "A cell projection is a cell protrusion such as pseudopodium, filopodium, lamellipodium, growth cone, flagellum, acrosome, axon, or bacterial comet tail. These membrane-cytoskeleton-coupled processes are involved in many biological functions, such as cell motility, cancer-cell invasion, endocytosis, phagocytosis, exocytosis, pathogen infection, neurite extension and cytokinesis. ",
"synonyms": "Cell protrusion.; ",
"content": "Cell projection.",
"is_a": null,
"part_of": null,
"keyword": "KW-0966",
"gene_ontology": "GO:0042995; cell projection; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Perikaryon.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0197",
"definition": "The perikaryon is the cell body of a neuron. ",
"synonyms": "cell body; Perikarya; soma.; ",
"content": "Perikaryon.",
"is_a": null,
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0043204; perikaryon; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Clathrin-coated vesicle.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0070",
"definition": "Clathrin coated vesicles (CCVs) mediate the vesicular transport of cargo such as proteins between organelles in the post-Golgi network connecting the trans-Golgi network, endosomes, lysosomes and the cell membrane. CCVs that bud from the cell membrane reveal a striking polyhedral pattern reminiscent of a fullerene which arises from the outermost protein in the coat, clathrin. Clathrin assembles from three-legged individual components called triskelions to form a polygonal lattice around the vesicle. Clathrin is a large heterohexameric protein complex composed of three heavy chains and three light chains. Clathrin molecules self-assemble together to make a spherical clathrin lattice structure, a polyhedron made of regular pentagons and hexagons. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. The connection of the clathrin scaffold to the membrane is mediated by clathrin adaptors, which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes. Clathrin-associated adaptor protein (AP) complexes are a stoichiometric coat component of CCVs alongside clathrin itself, and are considered a major clathrin adaptor contributing the CCV formation. ",
"synonyms": "CCV.; ",
"content": "Cytoplasmic vesicle, clathrin-coated vesicle.",
"is_a": "Cytoplasmic vesicle.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0030136; clathrin-coated vesicle; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Caveola.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0035",
"definition": "The caveola is a small (apparently) uncoated pit mostly found in the cell membrane of many highly differentiated mammalian cells, such as adipocytes, endothelial cells and muscle cells. These flask-shaped invaginations are defined by the presence of caveolins and contains a subset of lipid-raft components, including cholesterol and sphingolipids. Caveolae each comprise a caveolar bulb with a diameter of 60-80 nm, connected to an opening of fairly constant diameter. Caveolae might exists as single pits or can form a cluster of caveolae with non-caveolar membrane between the pits. In many tissues, and particularly in adipocytes, multiple caveolae are arranged around a central vacuolar domain. In developing muscle fibres, multiple caveolae are connected by a single neck to the cell membrane, producing large chains of interconnected caveolae. Another structural feature of caveolae in certain endothelia is the presence of a stomatal diaphragm, which consists of a central density and radial spikes, in the neck of the caveolae. Mature caveolae might be assembled in the Golgi apparatus. Caveolae can flatten out into the cell membrane, thereby loosing their caveolar identity. ",
"synonyms": "Caveolae; Membrane microdomain; Plasmalemmal vesicle.; ",
"content": "Membrane, caveola.",
"is_a": null,
"part_of": "Endomembrane system.; ",
"keyword": null,
"gene_ontology": "GO:0005901; caveola; ",
"annotation": null,
"references": "PubMed=17318224; DOI=10.1038/nrm2122;; ",
"links": null
},
{
"location_identifier": "Calyx.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0032",
"definition": "The calyx is a large cytoskeletal component of the perinuclear theca of the mammalian sperm head. ",
"synonyms": "Calyces; Cytoskeletal calyx.; ",
"content": "Cytoplasm, cytoskeleton, perinuclear theca, calyx.",
"is_a": null,
"part_of": "Perinuclear theca.; ",
"keyword": null,
"gene_ontology": "GO:0033150; cytoskeletal calyx; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Cajal body.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0031",
"definition": "The nuclear Cajal bodies (CBs) are small subnuclear membraneless organelles present either free in the nucleoplasm and/or physically associated to specific regions of chromatin. CBs contain newly assembled small nuclear ribonucleoproteins (snRNPs) and small nucleolar ribonucleoproteins (snoRNPs) particles, which are involved in pre-mRNA splicing and in ribosomal RNA processing, respectively. Mammalian nucleus in interphase, show 2-6 CBs, as irregular, punctuate structures, which vary in size and shape and which are often juxtaposed to nucleoli. At the electronic-microscope level, they are composed of heterogeneous mixture of electro-dense particles with diameters ranging from 20-25 nm and are called coiled body. Structures similar to CBs have been identified in the amphibian oocyte nucleus (called sphere organelles) and in insect (called endobodies). CBs are motile and dynamic structures. Both their protein and RNA-protein components can cycle continuously between CBs and other nuclear locations depending on the transcriptional state of the cell. ",
"synonyms": "Cajal bodies; Coiled body; Endobodies; Nucleolar accessory bodies;; Sphere organelles.; ",
"content": "Nucleus, Cajal body.",
"is_a": "Nuclear body.; ",
"part_of": "Nucleus.; ",
"keyword": null,
"gene_ontology": "GO:0015030; Cajal body; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Nucleus speckle.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0186",
"definition": "The nuclear speckles are small subnuclear membraneless organelles or structures, also called the splicing factor (SF) compartments that correspond to nuclear domains located in interchromatin regions of the nucleoplasm of mammalian cells. Protein found in speckles serves as a reservoir of factors that participate in transcription and pre-mRNA processing. Speckles appear, at the immunofluorescence-microscope level, as irregular, punctuate structures, which vary in size and shape. Usually 25-50 speckles are observed per interphase mammalian nucleus. At the electronic-microscope level, they are composed of heterogeneous mixture of electro-dense particles with diameters ranging from 20-25 nm and are called interchromatin granules clusters (IGCs). Speckles are dynamic structures. Both their protein and RNA- protein components can cycle continuously between speckles and other nuclear locations depending on the transcriptional state of the cell. Structures similar to nuclear speckles have been identified in the amphibian oocyte nucleus (called B snurposomes) and in Drosophila melanogaster embryos, but not in yeast. ",
"synonyms": "B snurposome; IGC; Interchromatin granules clusters; Nuclear speck;; Nuclear speckle; SF compartments; Splicing Factor compartments;; Splicing speckle.; ",
"content": "Nucleus speckle.",
"is_a": "Nuclear body.; ",
"part_of": "Nucleus.; ",
"keyword": null,
"gene_ontology": "GO:0016607; nuclear speck; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Basolateral cell membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0026",
"definition": "The basolateral cell membrane is the fraction of the plasma membrane at the basolateral side of the cell, which faces adjacent cells and the underlying connective tissue. ",
"synonyms": "Basolateral plasma membrane.; ",
"content": "Basolateral cell membrane.",
"is_a": null,
"part_of": "Cell membrane.; ",
"keyword": null,
"gene_ontology": "GO:0016323; basolateral plasma membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Basal cell membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0024",
"definition": "The basal cell membrane is the fraction of the plasma membrane at the basal side of the cell, which faces the underlying connective tissue. ",
"synonyms": "Basal plasma membrane.; ",
"content": "Basal cell membrane.",
"is_a": null,
"part_of": "Cell membrane.; ",
"keyword": null,
"gene_ontology": "GO:0009925; basal plasma membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Cellular thylakoid.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0043",
"definition": "A bacterial thylakoid membrane usually formed by extensive invaginations of the cell inner (plasma) membrane. In cyanobacteria thylakoids house the photosynthetic machinery and pigments. In Synechocystis sp. strain PCC 6803 the thylakoid membranes are physically discontinuous from the plasma membrane, and thus represent bona fide intracellular organelles. ",
"synonyms": "Bacterial thylakoid.; ",
"content": "Cellular thylakoid.",
"is_a": "Thylakoid.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0030075; bacterial thylakoid; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Bacterial extracellular vesicle.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0489",
"definition": "Small membrane vesicle (< 1 um) that buds off a prokaryotic cell's plasma membrane, able to carry proteins, phospholipids, lipopolysaccharides, nucleic acids, viruses, etc. Bacterial extracellular vesicles are important in intercellular communication and pathogenesis, and can exist within host cells. ",
"synonyms": "Bacterial membrane vesicle; Membrane vesicle; Microvesicle.; ",
"content": "Extracellular vesicle, bacterial extracellular vesicle.",
"is_a": "Extracellular vesicle.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0097691; bacterial extracellular vesicle; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Bacterial flagellum basal body.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0142",
"definition": "The basal body of a bacterial flagellum is a rod and a system of rings embedded in the cell envelope. Gram-negative flagella usually have an L ring in the plane of the lipopolysaccharide in the outer membrane, a periplasmic P ring in the plane of the peptidoglycan around the flagellar rod and a MS ring that is located within and above the cytoplasmic membrane. A C ring extends into the cytoplasm. The rod is a major component of the flagellar basal body and it spans the bacterial periplasm. The L and P rings are not found in Gram-positive bacteria. ",
"synonyms": "Bacterial flagellar basal body; Bacterial flagellar kinetosome;; Bacterial flagellar motor.; ",
"content": "Bacterial flagellum basal body.",
"is_a": null,
"part_of": "Bacterial flagellum.; ",
"keyword": null,
"gene_ontology": "GO:0009425; bacterial-type flagellum basal body; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Bacterial flagellum hook.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0357",
"definition": "The hook of a bacterial flagellum connects the basal body and the filament and acts as a universal joint. This flexible hinge relays the energy generated by the motor into torque formation that is transferred onto the rigid filament. ",
"synonyms": "Bacterial flagella hook; Bacterial flagellar hook.; ",
"content": "Bacterial flagellum hook.",
"is_a": null,
"part_of": "Bacterial flagellum.; ",
"keyword": null,
"gene_ontology": "GO:0009424; bacterial-type flagellum hook; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Bacterial flagellum filament.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0358",
"definition": "The bacterial flagellar filament is made of polymerized flagellin. ",
"synonyms": "Bacterial flagella filament; Bacterial flagellar filament.; ",
"content": "Bacterial flagellum filament.",
"is_a": null,
"part_of": "Bacterial flagellum.; ",
"keyword": null,
"gene_ontology": "GO:0009420; bacterial-type flagellum filament; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Bacterial flagellum.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0307",
"definition": "The flagellum of Bacteria is a long hair-like cell surface appendage. The flagellar apparatus consists of the flagellar filament made of polymerized flagellin (the propeller), the hook-like structure near the cell surface (the universal joint) and the basal body (the engine) which is a rod and a system of rings embedded in the cell envelope. The basal body and the hook anchor the whip-like filament to the cell surface. The flagellum is a rotating structure whose switches propels the cell through a liquid medium. ",
"synonyms": "Bacterial flagella; Bacterial flagellar apparatus.; ",
"content": "Bacterial flagellum.",
"is_a": null,
"part_of": null,
"keyword": "KW-0975",
"gene_ontology": "GO:0009288; bacterial-type flagellum; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Presynapse.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0516",
"definition": "In the synapse, the specialized axon's terminal end of the presynaptic cell that contains the specialized apparatus necessary to release neurotransmitters to the synaptic cleft. ",
"synonyms": "Axon terminal; Pre-synapse; Presynaptic bouton; Presynaptic region;; Presynaptic terminal.; ",
"content": "Presynapse.",
"is_a": null,
"part_of": "Synapse.; Axon.; ",
"keyword": null,
"gene_ontology": "GO:0098793; presynapse; ",
"annotation": null,
"references": null,
"links": null
}
]
}