HTTP 200 OK
Allow: GET, POST, HEAD, OPTIONS
Content-Type: application/json
Vary: Accept
{
"count": 543,
"next": "https://cinder.proteo.info/api/subcellular_locations/?format=api&limit=20&offset=540&ordering=location_identifier",
"previous": "https://cinder.proteo.info/api/subcellular_locations/?format=api&limit=20&offset=500&ordering=location_identifier",
"results": [
{
"location_identifier": "Tegument.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0263",
"definition": "The tegument of schistosomes is an outer-surface covering blood- dwelling flatworms. This unique structure consists of a double phospholipid bilayer (also known as the heptalaminar outer-surface structure) that ovelay a syncytium of fused cells surrounding the entire worm. These outer-tegumental membranes form many surface pits that substantially increase the surface area of the schistosome. The underlying syncytial-matrix contains some mitochondria, many vesicular structures and an extensive cytoskeleton. A basal lamina separates the syncytium from a layer of muscle cells. Nuclei and ribosomes are located in cytons, which are located underneath the muscle layer and connected by microtubule-lined cytoplasmic connections. ",
"synonyms": null,
"content": "Tegument.",
"is_a": null,
"part_of": null,
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Tegument membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0264",
"definition": "The membrane suroounding the tegument of schistosomes. ",
"synonyms": "Tegumental membrane.; ",
"content": "Tegument membrane.",
"is_a": "Membrane.; ",
"part_of": "Tegument.; ",
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Telomere.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0276",
"definition": "The telomere is a nucleoprotein structure comprising the terminal section of a eukaryotic chromosome. It has a specialized structure which is replicated by a special process, thereby counteracting the tendency of a chromosome to be shortened during each round of replication. ",
"synonyms": "Chromosome, telomeric region.; ",
"content": "Chromosome, telomere.",
"is_a": null,
"part_of": "Chromosome.; ",
"keyword": "KW-0779",
"gene_ontology": "GO:0000781; chromosome, telomeric region; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Thylakoid.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0450",
"definition": "The thylakoid is a membranous cellular structure containing the photosynthetic pigments, reaction centers and electron-transport chain. In chloroplast, thylakoids stack up to form the grana or stay as single cisternae and interconnect the grana. Thylakoid, where photosynthesis occurs, are found in chloroplasts, cyanelles and in photosynthetic bacteria where they are the extensive invaginations of the plasma membrane. ",
"synonyms": null,
"content": "Thylakoid.",
"is_a": null,
"part_of": null,
"keyword": "KW-0793",
"gene_ontology": "GO:0009579; thylakoid; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Tight junction.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0265",
"definition": "The tight junction (TJ) is a dynamic, multifunctional complex which, together with adherens junctions and desmosomes, maintains the integrity of the epithelial cell layer(s) that protects multicellular organisms. TJ is located at the apical-most portion of the intercellular junction. It separates the apical and basolateral compartments of epithelia (preventing the lateral diffusion of lipids and proteins between the apical and basolateral domains of plasma membrane) and plays a key role in limiting paracellular permeability to ions and solutes in a charge and size selective manner. TJs appear as multiple strands of fibrils forming a continuous circumferential seal around cells. ",
"synonyms": "TJ; Zonula occludens.; ",
"content": "Cell junction, tight junction.",
"is_a": "Cell junction.; ",
"part_of": null,
"keyword": "KW-0796",
"gene_ontology": "GO:0005923; bicellular tight junction; ",
"annotation": "Add \"Cell membrane\" if the protein is clearly associated with the membrane. ",
"references": null,
"links": "http://celljunctions.med.nyu.edu/desmosomes/desframe.html; "
},
{
"location_identifier": "trans-Golgi network.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0266",
"definition": "The trans-Golgi network is a highly dynamic series of interconnected tubules and vesicles at the trans face of the Golgi stack. The trans- Golgi network functions in the processing and sorting of glycoproteins and glycolipids at the interface of the biosynthetic and endosomal pathways. The generation and maintenance of apical and basolateral membranes rely on sorting events that occur in the TGN. ",
"synonyms": "Golgi trans-face; TGN; trans-Golgi; trans-Golgi complex.; ",
"content": "Golgi apparatus, trans-Golgi network.",
"is_a": null,
"part_of": "Golgi apparatus.; ",
"keyword": null,
"gene_ontology": "GO:0005802; trans-Golgi network; ",
"annotation": "The TGN is different from the trans-cisternae of the Golgi stack. Compartment specific marker: TGOLN2/TGN46. ",
"references": null,
"links": null
},
{
"location_identifier": "trans-Golgi network membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0267",
"definition": "The membrane surrounding the trans-Golgi network. ",
"synonyms": "Golgi trans-face membrane; TGN membrane; trans-Golgi complex membrane;; trans-Golgi membrane.; ",
"content": "Golgi apparatus, trans-Golgi network membrane.",
"is_a": "Golgi apparatus membrane.; ",
"part_of": "trans-Golgi network.; ",
"keyword": null,
"gene_ontology": "GO:0032588; trans-Golgi network membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Trichocyst.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0268",
"definition": "The trichocyst is an architecturally complex secretory granule having a highly constrained shape docked at specialized cortical sites in Paramecium and other ciliates. Each cell bears about 1'000 trichocysts, which are supposed to be defensive organelles against predators. Trichocyst consists of a spindle-shaped body bearing at its wide end a tip often compared to an inverted golf tee. An external stimulus can trigger massive and synchronous exocytosis. After exocytotic membrane fusion, contact with the H2O and calcium ions in the external medium leads to an extremely rapid (< 50 ms) and irreversible expansion of the trichocyst contents, to yield a second, needle-shaped form which remains insoluble. ",
"synonyms": null,
"content": "Trichocyst.",
"is_a": null,
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0055039; trichocyst; ",
"annotation": null,
"references": "PubMed=10865117; DOI=10.1016/s0300-9084(00)00201-7;; ",
"links": null
},
{
"location_identifier": "T-tubule.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0505",
"definition": "T-tubules are invaginations of the sarcolemma penetrating into the myocyte interior, forming a highly branched and interconnected network that makes junctions with the sarcoplasmic reticulum. T-tubules are selectively enriched with specific ion channels and proteins crucial in the development of calcium transients necessary in excitation- contraction coupling, thereby facilitating a fast and synchronous contraction across the entire cell volume. T-tubules are unique to striated muscle cells, i.e. skeletal and cardiac muscle cells. ",
"synonyms": "Transverse-axial tubular system; Transverse tubule.; ",
"content": "Cell membrane, sarcolemma, T-tubule.",
"is_a": null,
"part_of": "Sarcolemma.; ",
"keyword": null,
"gene_ontology": "GO:0030315; T-tubule; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "U-body.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0553",
"definition": "Non-membranous cytoplasmic structures containing Uridine-rich small nuclear ribonucleoproteins (U snRNPs) and snRNP assembly factors. U- bodies probably function as assembly or storage sites for snRNPs prior to their import into the nucleus. U-bodies associate with P-bodies and may cooperate in snRNP metabolism. ",
"synonyms": "Cytoplasmic U snRNP body; U bodies; U-bodies; U body.; ",
"content": "Cytoplasm, U-body.",
"is_a": "Cytoplasmic ribonucleoprotein granule.; ",
"part_of": null,
"keyword": null,
"gene_ontology": null,
"annotation": null,
"references": "PubMed=17183357; DOI=10.1073/pnas.0704977104;; ",
"links": null
},
{
"location_identifier": "Uropodium.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0141",
"definition": "The uropodium is a rigid membrane projection with related cytoskeletal components at the trailing edge of a lymphocyte or other cell in the process of migrating or being activated, found on the opposite side of the cell from the lamellipodium or immunological synapse, respectively. ",
"synonyms": "Uropod; Uropodia.; ",
"content": "Cell projection, uropodium.",
"is_a": "Cell projection.; ",
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0001931; uropod; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Vacuole.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0272",
"definition": "The vacuole is a generally large fluid-filled membrane-bound compartment in the cytoplasm. The precise form and function of vacuoles may vary between phyla. Plant vacuoles are among the best characterized. They differ in terms of their lumenal contents and processing enzymes, as well as on the basis of the type of integral proteins in their membranes (tonoplast intrinsic proteins, TIPs). Examples include the lytic vacuole, the storage vacuole and the lutoid. One important function of plant vacuoles is the maintenance of hydrostatic pressure. Other eukaryotes employ vacuoles for a variety of purposes, including storage (as in the yeast lysosome/vacuole), secretion and phagocytosis. In Protozoa, contractile vacuoles can be used to discharge water from the cytoplasm to the external environment. ",
"synonyms": null,
"content": "Vacuole.",
"is_a": null,
"part_of": null,
"keyword": "KW-0926",
"gene_ontology": "GO:0005773; vacuole; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Vacuole lumen.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0270",
"definition": "The lumen of a vacuole is the area enclosed by the vacuolar membrane. ",
"synonyms": "Vacuolar lumen.; ",
"content": "Vacuole lumen.",
"is_a": null,
"part_of": "Vacuole.; ",
"keyword": null,
"gene_ontology": "GO:0005775; vacuolar lumen; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Vacuole membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0271",
"definition": "The membrane surrounding a vacuole. ",
"synonyms": "Vacuolar membrane.; ",
"content": "Vacuole membrane.",
"is_a": "Membrane.; ",
"part_of": "Endomembrane system.; Vacuole.; ",
"keyword": null,
"gene_ontology": "GO:0005774; vacuolar membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Vesicle.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0498",
"definition": "A vesicle is a small structure consisting of fluid enclosed by a lipid bilayer. Vesicles form naturally during the processes of secretion (exocytosis), uptake (endocytosis) and transport of materials within the cytoplasm or between cells, and exist both within the cell and in the extracellular space. ",
"synonyms": null,
"content": "Vesicle.",
"is_a": null,
"part_of": null,
"keyword": null,
"gene_ontology": "GO:0031982; vesicle; ",
"annotation": null,
"references": "PubMed=24769233; DOI=10.1016/j.jprot.2014.04.028;; ",
"links": null
},
{
"location_identifier": "Virion.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0274",
"definition": "The virion is the complete fully infectious extracellular virus particle. ",
"synonyms": null,
"content": "Virion.",
"is_a": null,
"part_of": null,
"keyword": "KW-0946",
"gene_ontology": null,
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Virion membrane.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0275",
"definition": "The membrane surrounding the virion. ",
"synonyms": null,
"content": "Virion membrane.",
"is_a": "Membrane.; ",
"part_of": "Virion.; ",
"keyword": null,
"gene_ontology": "GO:0055036; virion membrane; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Virion tegument.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0273",
"definition": "The viral tegument is a protein structure that resides between the capsid and envelope of herpesviruses and which appears amorphous in electron micrographs. ",
"synonyms": "Viral tegument.; ",
"content": "Virion tegument.",
"is_a": null,
"part_of": "Virion.; ",
"keyword": "KW-0920",
"gene_ontology": "GO:0019033; viral tegument; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Z line.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0314",
"definition": "Z-disks are the lateral boundaries of a single sarcomere. In electron micrographs of cross striated muscle the Z line appears as a series of dark lines. They represent a key interface between the contractile apparatus and the cytoskeleton. The Z line (from the German \"Zwischen\") largely consists of alpha-actinin homodimers organized in an antiparallel fashion, thereby providing a backbone for the insertions of actin-based thin filaments, as well as titin and nebulin/nebulette. Z line of neighbouring sarcomeres are aligned in parallel and connected via the intermediate filament protein desmin. They maintain the actin filaments in a tetragonal lattice. ",
"synonyms": "Z-band; Z bodies; Z body; Z disc; Z-disc; Z disk; Z-disk; Z-line.; ",
"content": "Cytoplasm, myofibril, sarcomere, Z line.",
"is_a": null,
"part_of": "I band.; ",
"keyword": null,
"gene_ontology": "GO:0030018; Z disc; ",
"annotation": null,
"references": null,
"links": null
},
{
"location_identifier": "Zona pellucida.",
"topology_identifier": null,
"orientation_identifier": null,
"accession": "SL-0540",
"definition": "Zona pellucida is a specialized extracellular matrix that surrounds the plasma membrane of mammalian oocytes. It is required for successful fertilization. Zona pellucida allows species-specific fertilization, prevents polyspermy, and enables acrosomal reaction for the successful adhesion and penetration of the sperm cell. ",
"synonyms": "Egg coat; Pellucid zone; Vitelline membrane.; ",
"content": "Zona pellucida.",
"is_a": null,
"part_of": "Extracellular matrix.; ",
"keyword": "KW-0272",
"gene_ontology": "GO:0035805; egg coat; ",
"annotation": null,
"references": null,
"links": null
}
]
}